Hyaluronic acid-modified selenium nanoparticles for enhancing the therapeutic efficacy of paclitaxel in lung cancer therapy

Abstract

Targeted delivery of chemotherapeutics by functionalized nanoparticles exhibits a wonderful prospect for cancer treatment. In this paper, selenium nanoparticles (SeNPs) was linked with hyaluronic acid (HA) to prepare tumor-targeted delivery vehicle HA-SeNPs, and HA-SeNPs was loaded with paclitaxel (PTX) to fabricate functionalized selenium nanoparticles HA-Se@PTX. HA-Se@PTX showed greater uptake in A549 cells in comparison with that in HUVEC, verifying HA-mediated specific uptake of HA-Se@PTX. HA-Se@PTX was capable of entering A549 cells via clathrin-associated endocytosis and showed faster drug release in cancer cell microenvironment in comparison with normal physiological environment. HA-Se@PTX could obviously inhibit the proliferation, migration and invasion of A549 cells and trigger A549 cells apoptosis. Moreover, active targeting functionalized selenium nanoparticles HA-Se@PTX showed greater in vivo antitumor activity compared with free PTX or passive targeting delivery system Se@PTX. In addition, HA-Se@PTX exhibited negligible toxicity on the major organs of mice. In a word, HA-Se@PTX may develop into a valuable nanoscale antitumor drug agent for lung cancer treatment.

The Advancing of Selenium Nanoparticles Against Infectious Diseases

“…During the formation of Selenium element, the presence of some templates, also recognized as stabilizers, would lead these Selenium element to form nano-sized particles in aqueous solutions. A lot of chemicals can be used as templates for Se NPs preparation, such as chitosan (Bai et al, 2017), folate (Pi et al, 2013), hyaluronic acid (Zou et al, 2019),polyethylenimine (PEI) and ferulic acid (Cui et al, 2018b). In terms of the low cost, convenient procedure and controllable size, these template methods thus offer novel design of Se NPs with high efficacy.…”

Potentialities of bioinspired metal and metal oxide nanoparticles in biomedical sciences

“…The HA-SeNPs efficiently controlled the immune-regulating properties and decreased the tumor mass. [171][172][173][174] Moreover, a study reported that magnesium oxide nanoparticles combined with human serum albumin exhibited better plasma distribution and mediate apoptosis by ROS induced in the cell lines of cancer. 175 Furthermore, a similar study on magnesium oxide (MgO) nanostructures showed excellent photocatalytic, antibacterial, and anticancer performance.…”

Targeting Strategies for Enhancing Paclitaxel Specificity in Chemotherapy

“…Anti-MDR drugs (such as apatinib) co-delivered together with PTX have shown a favorable efficacy enhancement (Zhang et al, 2020). It was found that HA-functionalized vehicles with a PTX payload notably suppressed tumor invasion, migration, and proliferation, including micelles (HA-CA), selenium NPs (HA-Se@PTX), and mesoporous hollow alumina NPs (PAC-HMHA) (Thomas et al, 2015;Gao et al, 2019;Zou et al, 2019;. Previous studies have shown that HA-coated nanostructured lipids delivering PTX remarkably prolonged blood retention and tumor accumulation compared with Taxol (Yang et al, 2013).…”