Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis

Pavelka, Karel; Forejtová, Šárka; Olejárova, M.; Gatterová, J; Šenolt, Ladislav; Špaček, P.; Braun, M.; Hulejová, M.; Šťovíčková, Jitka; Pavelková, A.

doi:10.1016/j.joca.2004.01.001

Cited by 88 publications

(66 citation statements)

References 29 publications

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“…Increasing intra-articular HA is then forced into blood and lymph due to increasing intra-articular pressure [21]. Furthermore, HA is a component of cartilage, and radiographic joint-space narrowing by cartilage damage is correlated with higher serum HA levels [13]. On the other hand, it is considered that serum biomarkers are affected by other systemic factors, such as medical problems associated with aging, circadian rhythm, food intake and vigorous activities [15] because data are obtained from blood samples.…”

Section: Discussionmentioning

confidence: 99%

“…P value <0.05 significant for this biomarker. Previous reports have suggested that serum HA levels are associated with several joints [5,[7][8][9][10][11][12][13]. In the literature, there is a major focus on the relationship between knee OA and serum HA levels [5,7,[10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…Inoue et al reported that radiographic severity of knee OA and knee pain were correlated with serum HA levels, which suggests that serum HA levels reflect OA activity [11]. Furthermore, it is expected that this biomarker predicts OA progression [13]. Also, the presence of erosive hand OA in interphalangeal and wrist joints increases serum HA levels [8].…”

Section: Discussionmentioning

confidence: 99%

“…Among them, serum hyaluronan (HA) level is considered a good biomarker for reflecting cartilage damage and synovitis in OA patients [6,7]. Previous studies show its association with the presence [7][8][9], duration [10] and severity of radiographic OA [11]; degree of pain [5,11,12]; and OA progression [13]. However, systemic biomarkers have negative aspects, as they are affected by many factors related to aging [14] and physical activity [15].…”

Section: Introductionmentioning

confidence: 99%

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Serum hyaluronan levels increase with the total number of osteoarthritic joints and are strongly associated with the presence of knee and finger osteoarthritis

Sasaki

Tsuda

Yamamoto

et al. 2013

International Orthopaedics (SICOT)

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Purpose Although serum hyaluronan (HA) levels increase in patients with osteoarthritis (OA), the association between OA severity and elevation of serum HA levels is not clear. Our purpose was to investigate the relationship between serum HA levels and OA in various anatomical sites and to detect which joints are strongly correlated with elevated serum HA levels. Methods Seven hundred and ten individuals from the general population who participated in the Iwaki Health Promotion Project in 2008 were involved. Kellgren-Lawrence grade 2 or higher in the knee, hip, lumbar spine, finger and wrist was defined as OA. Serum HA levels were determined on the same day. Spearman's correlation coefficients between serum HA levels and total number of joints affected by OA were calculated. Linear regression was analysed with serum HA levels as the independent variable; age, gender, presence of OA and intake of supplements were used as dependent variables.Results Prevalence of knee OA was 30.7 %, hip 16.8 %, lumbar spine 65.1 %, wrist 9.0 % and finger 22.0 %. Serum HA levels had a positive correlation with the number of involved joints, and the correlation coefficient was 0.410 (p<0.001). Serum HA was significantly affected by age (β=0.382), knee OA (β=0.163) and finger OA (β=0.164). Conclusion Although this biomarker reflects a systemic condition, higher serum HA levels were associated with total number of OA joints. Knee and finger OA were key joints related to increased serum HA levels. These results are valuable in understanding characteristics of serum HA levels as a biomarker for osteoarthritis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum hyaluronan levels increase with the total number of osteoarthritic joints and are strongly associated with the presence of knee and finger osteoarthritis

Sasaki

Tsuda

Yamamoto

et al. 2013

International Orthopaedics (SICOT)

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“…These 2 markers have been used in human studies and are shown to be indicative of various aspects of OA. HA is a glycosaminoglycan found in synovium and cartilage that predicts disease outcome in knee (39) and hip OA (40) and correlates with OA progression (39)(40)(41)(42)(43)(44)(45). To date, there are few data regarding serum or synovial fluid biomarker levels following articular fracture and the subsequent development of arthritis.…”

mentioning

confidence: 99%

Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse

Ward¹,

Furman²,

Huebner³

et al. 2008

Arthritis & Rheumatism

112

127

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Objective. Posttraumatic arthritis is a frequent long-term complication of intraarticular fractures. A model of a closed intraarticular fracture in C57BL/6 mice that progresses to posttraumatic arthritis has been developed. The MRL/MpJ mouse has shown unique regenerative abilities in response to injury. The objective of this study was to determine if the MRL/MpJ mouse is protected from posttraumatic arthritis after intraarticular fractures.Methods. Intraarticular fractures were created in MRL/MpJ mice and C57BL/6 control mice (n ‫؍‬ 16 each). Limbs were analyzed for posttraumatic arthritis 4 and 8 weeks after fracture using microfocal computed tomography bone morphology, subchondral bone thickness evaluation, and histologic evaluation of cartilage degeneration. Serum cytokines and biomarkers were measured after the mice were killed.Results. Intraarticular fractures were successfully created in all 32 mice. In the experimental fractured limbs, C57BL/6 mice had a decrease in bone density, increased subchondral bone thickness, and increased cartilage degeneration compared with normal contralateral control limbs. In the MRL/MpJ mice, no differences in bone density, subchondral bone thickness, or histologic grading of cartilage degeneration were seen between fractured and contralateral control limbs. Cytokine analysis showed lower systemic levels of the proinflammatory cytokine interleukin-1␣ (IL-1␣) and higher levels of the antiinflammatory cytokines IL-4 and IL-10 in the MRL/MpJ mice.Conclusion. This study shows that the MRL/MpJ mouse is relatively protected from posttraumatic arthritis after intraarticular fracture. Further investigation into the mechanism involved in this response will hopefully provide new insight into the pathogenesis, prevention, and treatment of posttraumatic arthritis after intraarticular fracture.

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Medical application of glycosaminoglycans: a review

Köwitsch

Zhou

Groth

2017

J Tissue Eng Regen Med

179

145

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The characteristic molecular composition of the different glycosaminoglycans (GAGs) is related to their role as structural components and regulators of a multitude of functions of proteins, cells and tissues in the human body. Therefore, it is not surprising that GAGs are widely used as coating materials for implants, components of 3D-constructs such as tissue engineering scaffolds and hydrogels, but also as diagnostic devices such as biosensors and in controlled release applications. Beside a physisorption or encapsulation of GAGs, these applications often require their chemical modification to allow a stable covalent attachment on surfaces or cross-linking reactions with other molecules. Then, the preservation of the functionality of GAGs under maintenance of their biocompatibility is a challenging task and must be addressed in accordance with the designated field of application. Here, we will give a brief overview on structure and biological functions of GAGs, different methods of their activation and immobilization, the recent progress in GAG-related biomaterials development, as well as some examples of their application in the field of tissue engineering and regenerative medicine.

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Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis

Abstract: In our study, serum levels of hyaluronic acid and pentosidine had a predictive value for further development of knee OA in that further joint space narrowing was detected in the patients with knee OA in the next 2 years.

Cited by 88 publications

References 29 publications

Serum hyaluronan levels increase with the total number of osteoarthritic joints and are strongly associated with the presence of knee and finger osteoarthritis

Serum hyaluronan levels increase with the total number of osteoarthritic joints and are strongly associated with the presence of knee and finger osteoarthritis

Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse

Medical application of glycosaminoglycans: a review

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