Hyaluronic acid in the treatment of postmenopausal women with atrophic vaginitis

Karaosmanoğlu, Özge; Çöğendez, Ebru; Sözen, Hamdullah; Asoğlu, Mehmet Reşit; Akdemir, Yeşim; Eren, Sadiye

doi:10.1016/j.ijgo.2010.12.007

Cited by 14 publications

(9 citation statements)

References 5 publications

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“…showed that HA significantly improved the combined score of symptoms of vaginal atrophy. 14 This result is consistent with the findings of Karaosmanoglu et al.’s study, which was excluded in our study due to the type of study (before and after study) and lack of control group, 22 and non-clinical trials of Tersigni et al., Sinha et al. and Origoni et al., 17,18,20 confirming the need for trials with more precise designs.…”

Section: Discussionsupporting

confidence: 91%

Comparison of the effect of hyaluronic acid and estrogen on atrophic vaginitis in menopausal women: A systematic review

Najjarzadeh

Mohammad‐Alizadeh‐Charandabi

Mohammadi

et al. 2019

Post Reprod Health

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This systematic review was conducted to compare the effectiveness of hyaluronic acid and estrogen on symptoms of atrophic vaginitis (primary outcomes) and corresponding side effects (secondary outcome). We reviewed all parallel clinical trials, systematically, to compare the effectiveness of hyaluronic acid and estrogen on atrophic vaginitis. We searched Pubmed, Embase, Web of Sciences, Cochrane library, Scopus, Google Scholar, Magiran, Scientific Information Database (Iran) and Iranian Registry of Clinical Trials, from inception to July 2018 and the reference lists of retrieved articles. Two reviewers used the Cochrane collaboration tool to assess the risk of bias independently. Five parallel controlled trials with 372 participants were included in the present systematic review. One trial reported estrogen superiority to hyaluronic acid in improving the symptoms of atrophic vaginitis. Three trials failed to show a significant statistical difference between the intervention groups. Only a trial with a high risk of bias in random allocation and blinding indicated that hyaluronic acid was more effective than estrogen in improving the symptoms of atrophic vaginitis. Hyaluronic acid is an effective drug with few side effects for the treatment of atrophic vaginitis symptoms; however, better designed trials are required to show the statistical superiority of hyaluronic acid to vaginal estrogen.

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Section: Discussionsupporting

confidence: 91%

Comparison of the effect of hyaluronic acid and estrogen on atrophic vaginitis in menopausal women: A systematic review

Najjarzadeh

Mohammad‐Alizadeh‐Charandabi

Mohammadi

et al. 2019

Post Reprod Health

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“…Plus ré cemment, une é tude ouverte a traité des femmes mé nopausé es depuis au moins deux ans et avec au moins un symptô me de vaginite atrophique avec des ovules à base d'AH [22]. La sé vé rité de tous les symptômes cliniques s'est amé lioré e à 90 jours, avec des taux de patientes asymptomatiques de 45,5 % pour l'é rythè me, de 36,8 % pour la dyspareunie, de 33,3 % pour le prurit et de 28,6 % pour la sé cheresse et l'irritation.…”

Section: Discussionunclassified

Efficacité d’un dispositif médical à base d’acide hyaluronique liposomé contre la sécheresse vulvo-vaginale

Bohbot

Bélilovsky

Brami³

et al. 2015

Gynécologie Obstétrique & Fertilité

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“…Other studies have demonstrated the efficacy and safety of hyaluronic acid vaginal treatment in the longer term . However, further blind trials are called for.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Efficacy and Safety of Hyaluronic Acid Vaginal Gel to Ease Vaginal Dryness: A Multicenter, Randomized, Controlled, Open-Label, Parallel-Group, Clinical Trial

Chen

Geng

Song

et al. 2013

The Journal of Sexual Medicine

135

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Introduction Atrophic vaginitis is a common occurrence, particularly among postmenopausal women; however, few seek or receive treatment. One therapeutic solution is topically applied products. Estrogen-based treatments have been shown to be effective; however, many patients are reluctant to use such formulations due to health concerns, hence the need to assess the efficacy of acceptable alternatives. Aim This multicenter, randomized, controlled, open-label, parallel-group clinical trial set out to evaluate the efficacy and safety of hyaluronic acid vaginal gel to treat vaginal dryness compared with estriol cream in postmenopausal women. Methods One hundred forty-four subjects were randomized, 72 to the test group treated with hyaluronic acid vaginal gel (Hyalofemme) and 72 to the control group treated with estriol cream (Ovestin). Treatment in both groups was applied by means of a device once every 3 days for a total of 10 applications over 30 days. Main Outcome Measures Efficacy was measured by grading vaginal dryness and three other vaginal symptoms on a visual analog scale. Safety assessments included vital signs, laboratory examinations of the vaginal microecosystem, vaginal pH value, vaginal B ultrasound, and incidence of adverse events. Assessments were performed at baseline, by telephone after the third application, and at the final visit. Results Both hyaluronic acid vaginal gel and estriol cream can significantly improve the clinical symptoms of vaginal dryness in postmenopausal women, with improvement rate of 84.44% and 89.42%, respectively, after 10 applications, without statistically significant difference between them. Conclusion Both hyaluronic acid vaginal gel and estriol cream are effective in the treatment of vaginal dryness. Hyaluronic acid vaginal gel may be considered as a valid alternative to estrogen-based treatments in relieving the symptoms of vaginal dryness.

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Hyaluronic acid in the treatment of postmenopausal women with atrophic vaginitis

Cited by 14 publications

References 5 publications

Comparison of the effect of hyaluronic acid and estrogen on atrophic vaginitis in menopausal women: A systematic review

Comparison of the effect of hyaluronic acid and estrogen on atrophic vaginitis in menopausal women: A systematic review

Efficacité d’un dispositif médical à base d’acide hyaluronique liposomé contre la sécheresse vulvo-vaginale

Evaluation of the Efficacy and Safety of Hyaluronic Acid Vaginal Gel to Ease Vaginal Dryness: A Multicenter, Randomized, Controlled, Open-Label, Parallel-Group, Clinical Trial

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