Hyaluronic acid concentrations in synovial fluid of dogs with different stages of osteoarthritis

Plickert, Hanna Dorothee; Bondzio, Angelika; Einspanier, Ralf; Tichy, Alexander; Brunnberg, Leo

doi:10.1016/j.rvsc.2012.11.007

Cited by 18 publications

(7 citation statements)

References 33 publications

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“…Previous studies have reported that sodium hyaluronate concentrations in the joint fluid and serum of animals with diseased joints were lower than normal [3,10,24]. Additionally, several studies using acute injury models have demonstrated decreasing HA concentrations in synovial fluid [3,10].…”

Section: Discussionmentioning

confidence: 99%

Effects of one-time and two-time intra-articular injection of hyaluronic acid sodium salt after joint surgery in dogs

Nganvongpanit

Boonsri²,

Sripratak³

et al. 2013

J Vet Sci

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Thirty-one dogs with patellar luxation (grades 2 and 3) were categorized into three groups. Group 1 (G.1; n = 12) had sodium hyaluronate (SHA) intra-articularly injected into the stifle joint that received surgery. Group 2 (G.2; n = 10) received SHA twice: first after surgery and then 1 week later. Group 3 (G.3; n = 9) served as a control, without injection. Blood was collected before injection and then once a week for 4 weeks after injection for evaluation of chondroitin sulfate (CS-WF6) and hyaluronan (HA). The results revealed significantly (p < 0.05) improved clinical scores by the end of week 4 in G.1 and G.2 relative to G.3; however, there was no significant difference between G.1 and G.2. There was a significant decrease (p < 0.05) in serum CS-WF6 levels beginning at week 2 in G.1 and G.2. At weeks 3 and 4, serum HA in G.1 and G.2 differed from that in G.3 (p < 0.05). No significant difference (p > 0.05) was observed in serum biomarkers between G.1 and G.2. In conclusion, intra-articular injection with SHA after joint surgery may improve homeostasis of the joint, retarding the process of OA.

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Section: Discussionmentioning

confidence: 99%

Effects of one-time and two-time intra-articular injection of hyaluronic acid sodium salt after joint surgery in dogs

Nganvongpanit

Boonsri²,

Sripratak³

et al. 2013

J Vet Sci

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“…The possible mechanisms are: (1) injected HA intraarticular can improve content of HA intra-articular, cover the surface of cartilago articularis and synovium, prevent deposition of hemoglobin particles in synovial surface and permeate to enchondral, and further influence metabolism of synovium and cartilage; [10,22] (2) injected HA intraarticular can restrict diffusion of inflammatory medium via molecular sieves; [23] (3) HA can accelerate composition of self-HA in synovial cells [24]. Exogenous HA entered into articular cavity can improve the surrounding environment of synovial cells, and have a regenerative feedback role in composition of self-HA in synovial cells [7].…”

Section: Discussionmentioning

confidence: 99%

Effects of hemarthrosis on cartilage and synovium in rabbits

Zhao

Chen

et al. 2016

Eur J Trauma Emerg Surg

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“…HA is a non‐sulfated GAG produced by chondrocytes and type B synoviocytes and is one of the main constituents of the synovial fluid and extracellular cartilage matrix (Venable and others 2008) (Fig 1). OA causes a decrease in HA, which critically impacts both the function and the metabolism of a joint (Plickert and others 2013). A decreased HA concentration has been measured in stifle joints with naturally occurring and experimentally induced CCLR compared to contralateral control joints (Budsberg and others 2006, Venable and others 2008) (Tables 3 and 4).…”

Section: Methodsmentioning

confidence: 99%

Canine synovial fluid biomarkers for early detection and monitoring of osteoarthritis

et al. 2017

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Secondary, non-inflammatory osteoarthritis (OA) is a common disorder in dogs. Its silent onset prevents early diagnosis and delays treatment. Synovial fluid biomarkers can detect OA at an early stage, before the presence of radiographic signs. In addition, these local biomarkers can aid prognosis of the disease, monitor the response to treatment and can be used to assess the degree of OA. Currently three groups of canine synovial fluid biomarkers have been the focus of research: proinflammatory mediators, enzymes and their inhibitors, and extracellular cartilage degeneration products. These have been investigated in the elbow, hip and stifle joints of both normal dogs and dogs with naturally occurring and experimentally induced OA. None of these biomarkers are currently used in practice for the detection of canine OA at an early stage. A positive relationship between canine synovial fluid biomarkers and OA has been demonstrated, yet no molecular diagnostic test has been developed so far.

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Hyaluronic acid concentrations in synovial fluid of dogs with different stages of osteoarthritis

Cited by 18 publications

References 33 publications

Effects of one-time and two-time intra-articular injection of hyaluronic acid sodium salt after joint surgery in dogs

Effects of one-time and two-time intra-articular injection of hyaluronic acid sodium salt after joint surgery in dogs

Effects of hemarthrosis on cartilage and synovium in rabbits

Canine synovial fluid biomarkers for early detection and monitoring of osteoarthritis

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