Hyaluronic acid coated bilirubin nanoparticles attenuate ischemia reperfusion-induced acute kidney injury

Huang, Zhiwei; Shi, Yannan; Zhai, Yuanyuan; Du, Chu-Chu; Zhai, Jiaoyuan; Yu, Run-Jie; Kou, Longfa; Xiao, Jian; Zhao, Ying‐Zheng; Yao, Qing

doi:10.1016/j.jconrel.2021.04.033

Cited by 56 publications

(44 citation statements)

References 48 publications

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“…We have screened for the optimal BR concentration (20 μM) in islet cells 17 and then used a relatively conservative dose (5 mg/kg) to treat acute kidney injury. 19 In this study, we also selected a low concentration of bilirubin for GU to allow BR to exert curative effects without causing significant toxic effects to the body.…”

Section: Resultsmentioning

confidence: 99%

“…Reflecting the characteristics of different diseases, many delivery strategies have been designed to exploit the therapeutic potential of BR. 19 Chitosan (CS) has been widely used in the field of medical materials and developing drug delivery system for treatment of GU because of its good mucoadhesive properties, biocompatibility, non-antigenicity, biodegradability, and broad-spectrum antimicrobial properties. 20,21 When used as a bioadhesive material or drug carrier, CS can adhere to the mucosal lesion and prolong the retention time of the drug at the lesion site.…”

Section: Introductionmentioning

confidence: 99%

“…Reflecting the characteristics of different diseases, many delivery strategies have been designed to exploit the therapeutic potential of BR. 19 …”

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers

Huang¹,

Shi²,

Wang³

et al. 2021

IJN

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Gastric ulcers (GU) are a disease of the gastrointestinal tract that can be caused by excessive alcohol consumption and heavy use of nonsteroidal anti-inflammatory drugs. GU manifests predominantly as pathological damage, such as extensive inflammatory erosion and superficial bleeding of the gastric mucosa. Oxidative stress damage and the inflammatory response are now considered important predisposing factors for GU, suggesting that antioxidant and anti-inflammatory drugs could be treatments for GU. Nanoparticle drug carriers offer many advantages over conventional drugs, such as improved drug efficiency, increased drug stability, and increased half-life. Methods: We designed chitosan-bilirubin conjugate (CS-BR) nanoparticles and assessed the anti-inflammatory and antioxidant abilities of CS-BR in gastric epithelial cells. Then, we evaluated the intragastric retention time and the anti-ulcer effects of CS-BR in vivo. Results:The in vitro data showed that CS-BR nanoparticles protect gastric epithelial cells against oxidative/inflammatory injury. The in vivo study demonstrated that CS-BR nanoparticles accumulate permanently in the stomach and exert powerful antioxidant and antiinflammatory effects against GU. Conclusion:This study applied bilirubin to the treatment of GU and confirmed that CS-BR nanoparticles are effective at alleviating acute GU in an experimental model. The findings provide innovative ideas for prophylaxis against or treatment of GU.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers

Huang¹,

Shi²,

Wang³

et al. 2021

IJN

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“…Hyaluronic acid is a disaccharide unit composed of D-glucuronic acid and N-acetylglucosamine, commonly used to construct drug delivery systems (Huang et al., 2021 ). It has good biocompatibility, degradability, non-inflammatory, nontoxic, and non-immune characteristics.…”

Section: Drug Delivery System (Dds) For Oa Therapymentioning

confidence: 99%

Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage

et al. 2022

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Osteoarthritis (OA) is a progressive chronic inflammation that leads to cartilage degeneration. OA Patients are commonly given pharmacological treatment, but the available treatments are not sufficiently effective. The development of sustained-release drug delivery systems (DDSs) for OA may be an attractive strategy to prevent rapid drug clearance and improve the half-life of a drug at the joint cavity. Such delivery systems will improve the therapeutic effects of anti-inflammatory effects in the joint cavity. Whereas, for disease-modifying OA drugs (DMOADs) which target chondrocytes or act on mesenchymal stem cells (MSCs), the cartilage-permeable DDSs are required to maximize their efficacy. This review provides an overview of joint structure in healthy and pathological conditions, introduces the advances of the sustained-release DDSs and the permeable DDSs, and discusses the rational design of the permeable DDSs for OA treatment. We hope that the ideas generated in this review will promote the development of effective OA drugs in the future.

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“…The in vivo study showed that LPNs penetrated into the viable epidermis and dermis region and significantly improved psoriasis area severity index (PASI) score, reduced skin damage and proliferation [21] . Hyaluronic acid (HA) has specific interaction with CD44 on cell surface [22 , 23] . Based on the overexpressed CD44 in inflamed psoriatic skin, Zhang et al developed a HA-conjugated and propylene glycol-based ethosomes to actively target CD44 in psoriatic skin for enhanced curcumin delivery for psoriasis treatment and found that this nanoparticle could increase the topical delivery of curcumin to inflamed skin and exert satisfactory therapeutic effect [24] .…”

Section: Introductionmentioning

confidence: 99%

Alantolactone-loaded chitosan/hyaluronic acid nanoparticles suppress psoriasis by deactivating STAT3 pathway and restricting immune cell recruitment

Chen

Zhai

Sun

et al. 2022

Asian Journal of Pharmaceutical Sciences

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Hyaluronic acid coated bilirubin nanoparticles attenuate ischemia reperfusion-induced acute kidney injury

Cited by 56 publications

References 48 publications

Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers

Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers

Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage

Alantolactone-loaded chitosan/hyaluronic acid nanoparticles suppress psoriasis by deactivating STAT3 pathway and restricting immune cell recruitment

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