Hyaluronic Acid Biomaterials for Central Nervous System Regenerative Medicine

Jensen, Gregory C.; Holloway, Julianne L.; Stabenfeldt, Sarah E.

doi:10.3390/cells9092113

Cited by 60 publications

(49 citation statements)

References 130 publications

(232 reference statements)

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“…Hyaluronic acid (HA) with linear structure and molecular weight ranging from 6,500 to 10,900 kDa is a component of all connective tissue ( Jensen et al, 2020 ). It is an anionic and non-sulfated glycosaminoglycan composed of alternating units of a repeating disaccharide, composed by d -glucuronic acid and N-acetyl- d -glucosamine ( Ahmadian et al, 2019 ; Murthy et al, 2019 ).…”

Section: Classification Of Hydrogelsmentioning

confidence: 99%

Rational Design of Smart Hydrogels for Biomedical Applications

Zhang

Huang

2021

Front. Chem.

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Hydrogels are polymeric three-dimensional network structures with high water content. Due to their superior biocompatibility and low toxicity, hydrogels play a significant role in the biomedical fields. Hydrogels are categorized by the composition from natural polymers to synthetic polymers. To meet the complicated situation in the biomedical applications, suitable host–guest supramolecular interactions are rationally selected. This review will have an introduction of hydrogel classification based on the formulation molecules, and then a discussion over the rational design of the intelligent hydrogel to the environmental stimuli such as temperature, irradiation, pH, and targeted biomolecules. Further, the applications of rationally designed smart hydrogels in the biomedical field will be presented, such as tissue repair, drug delivery, and cancer therapy. Finally, the perspectives and the challenges of smart hydrogels will be outlined.

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Section: Classification Of Hydrogelsmentioning

confidence: 99%

Rational Design of Smart Hydrogels for Biomedical Applications

Zhang

Huang

2021

Front. Chem.

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“…In the CNS, while structurally localized to myelinated fibers, HA secreted from neurons and astrocytes affects tissue homeostasis by taking part in the formation of perineuronal nets, functionally controlling neuroplasticity and brain development and maturation. A biocompatible, linear structure enables HA to bind to many cell surface receptors, bringing cells into response [ 106 ]. HA mostly engage the CD44 receptor, a glycoprotein on the surface of glial and neuronal cells.…”

Section: Biomaterials For the Cns And Covid-19: Mechanisms And Implicmentioning

confidence: 99%

“…4 Hyaluronic acid and its receptors and signaling pathways in neural and glial cells. Physiologically, they contribute to cell-specific behaviors, although by upregulation of TLR2 and TL4 signaling pathways they may play role in neuropathologies ( Prepared with data from [ 106 ]) …”

Section: Biomaterials For the Cns And Covid-19: Mechanisms And Implicmentioning

confidence: 99%

“…Using cross-linking mechanisms, including covalent and non-covalent mechanisms, HA-based biomaterials achieve a high degree of stability and a better biomechanical structure suited to different kinds of applications in the CNS for regeneration and repair (Fig. 5 ) [ 106 ]. HA-based biomaterials include hydrogels, granular hydrogels and microgels, and composite material systems [ 106 ].…”

Section: Biomaterials For the Cns And Covid-19: Mechanisms And Implicmentioning

confidence: 99%

“…5 ) [ 106 ]. HA-based biomaterials include hydrogels, granular hydrogels and microgels, and composite material systems [ 106 ].

Fig.…”

Section: Biomaterials For the Cns And Covid-19: Mechanisms And Implicmentioning

confidence: 99%

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Biosensing surfaces and therapeutic biomaterials for the central nervous system in COVID-19

Saghazadeh

Rezaei

2021

emergent mater.

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COVID-19 can affect the central nervous system (CNS) indirectly by inflammatory mechanisms and even directly enter the CNS. Thereby, COVID-19 can evoke a range of neurosensory conditions belonging to infectious, inflammatory, demyelinating, and degenerative classes. A broad range of non-specific options, including anti-viral agents and anti-inflammatory protocols, is available with varying therapeutic. Due to the high mortality and morbidity in COVID-19–related brain damage, some changes to these general protocols, however, are necessary for ensuring the delivery of therapeutic(s) to the specific components of the CNS to meet their specific requirements. The biomaterials approach permits crossing the blood–brain barrier (BBB) and drug delivery in a more accurate and sustained manner. Beyond the BBB, drugs can protect neural cells, stimulate endogenous stem cells, and induce plasticity more effectively. Biomaterials for cell delivery exist, providing an efficient tool to improve cell retention, survival, differentiation, and integration. This paper will review the potentials of the biomaterials approach for the damaged CNS in COVID-19. It mainly includes biomaterials for promoting synaptic plasticity and modulation of inflammation in the post-stroke brain, extracellular vesicles, exosomes, and conductive biomaterials to facilitate neural regeneration, and artificial nerve conduits for treatment of neuropathies. Also, biosensing surfaces applicable to the first sensory interface between the host and the virus that encourage the generation of accelerated anti-viral immunity theoretically offer hope in solving COVID-19.

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Microphysiological Blood‐Brain Barrier Systems for Disease Modeling and Drug Development

Mulay,

Hwang,

Kim

2024

Adv Healthcare Materials

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The blood‐brain barrier (BBB) is a highly controlled microenvironment that regulates the interactions between cerebral blood and brain tissue. Due to its selectivity, many therapeutics targeting various neurological disorders have not been able to penetrate brain tissue. Pre‐clinical studies using animals and other in vitro platforms have not shown the ability to fully replicate the human BBB leading to the failure of a majority of therapeutics in clinical trials. However, recent innovations in vitro and ex vivo modeling called Organs‐on‐chips have shown the potential to create more accurate disease models for improved drug development. These microfluidic platforms induce physiological stressors on cultured cells and have been able to generate more physiologically accurate BBBs compared to previous in vitro models. In this review, different approaches to creating BBBs‐on‐chips are explored alongside their application in modeling various neurological disorders and potential therapeutic efficacy. Additionally, organs‐on‐chips use in BBB drug delivery studies is discussed, and advances in linking brain organs‐on‐chips onto multiorgan platforms to mimic organ crosstalk are reviewed.This article is protected by copyright. All rights reserved

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Hyaluronic Acid Biomaterials for Central Nervous System Regenerative Medicine

Cited by 60 publications

References 130 publications

Rational Design of Smart Hydrogels for Biomedical Applications

Rational Design of Smart Hydrogels for Biomedical Applications

Biosensing surfaces and therapeutic biomaterials for the central nervous system in COVID-19

Microphysiological Blood‐Brain Barrier Systems for Disease Modeling and Drug Development

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