Microphysiological Blood‐Brain Barrier Systems for Disease Modeling and Drug Development
Atharva R. Mulay,
Jihyun Hwang,
Deok‐Ho Kim
Abstract:The blood‐brain barrier (BBB) is a highly controlled microenvironment that regulates the interactions between cerebral blood and brain tissue. Due to its selectivity, many therapeutics targeting various neurological disorders have not been able to penetrate brain tissue. Pre‐clinical studies using animals and other in vitro platforms have not shown the ability to fully replicate the human BBB leading to the failure of a majority of therapeutics in clinical trials. However, recent innovations in vitro and ex vi… Show more
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