Hyaluronic Acid-Based Nanomaterials for Cancer Therapy

Kim, Jin Hong; Moon, Myeong Ju; Kim, Dong Yi; Heo, Suk Hee; Jeong, Yong Yeon

doi:10.3390/polym10101133

Cited by 133 publications

(88 citation statements)

References 81 publications

(104 reference statements)

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“…HA has been shown to not elicit any immune response in the body and can be used as an efficient delivery system for cancer treatment [87,88]. Micelles, polymersomes, and hydrogels have been utilized as HA-based nanocarriers and NIR-responsive materials, such as NIR dyes, gold nanoparticles, graphene oxide nanoparticles, Prussian blue nanoparticles, and magnetic nanoparticles, have been widely used for cancer treatment and water solubility [86,88].…”

Section: Applications Of Ha-based Nanoparticlesmentioning

confidence: 99%

Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application

et al. 2019

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Nano- and microfibers based on biopolymers are some of the most attractive issues of biotechnology due to their unique properties and effectiveness. Hyaluronan is well-known as a biodegradable, naturally-occurring polymer, which has great potential for being utilized in a fibrous form. The obtaining of fibers from hyaluronan presents a major challenge because of the hydrophilic character of the polymer and the high viscosity level of its solutions. Electrospinning, as the advanced and effective method of the fiber generation, is difficult. The nano- and microfibers from hyaluronan may be obtained by utilizing special techniques, including binary/ternary solvent systems and several polymers described as modifying (or carrying), such as polyethylene oxide (PEO) and polyvinyl alcohol (PVA). This paper reviews various methods for the synthesis of hyaluronan-based fibers, and also collects brief information on the properties and biological activity of hyaluronan and fibrous materials based on it.

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Section: Applications Of Ha-based Nanoparticlesmentioning

confidence: 99%

Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application

et al. 2019

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“…Due to its high binding affinity to CD44 receptor, which are commonly observed to be overexpressed in many cancer types [31] including in GBM (reported in this present study), hyaluronic acid has been further developed for cancer-specific drugs or gene delivery nanomaterials [32,33]. Thus, the excellent features of hyaluronic acid in mediating enhanced drugs or genes delivery to cancer cells via the overexpressed CD44 receptor could potentially be applied and developed for novel GBM therapeutic strategies.…”

Section: Identifying Existing Drugs Targeting Gbm Signature and Cd44 mentioning

confidence: 61%

Integration of RNA-Seq and proteomics data identifies glioblastoma multiforme surfaceome signature

Syafruddin

Nazarie

Moidu

et al. 2020

Preprint

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BackgroundGlioblastoma multiforme (GBM) is a highly lethal, stage IV brain tumor with a prevalence of approximately 2 per 10000 people globally. The cell surface proteins or surfaceome play significant roles in modulating cancer phenotypes and acting as information gateway in many oncogenic signaling pathways. Hence, surfaceome are attractive targets for cancer therapy due to their direct accessibility to drugs. Nonetheless, a comprehensive GBM surfaceome landscape has not been fully defined. Thus, the aim of this study is to define GBM-specific surfaceome genes and identify key cell surface genes that could potentially be developed as novel GBM biomarkers, or therapeutically targeted.MethodsWe integrated the RNA-Seq data from TCGA GBM (n=166) and GTEx normal brain cortex (n=408) databases to identify the significantly dysregulated surfaceome in GBM. This was followed by integrative analysis that combines transcriptomics, proteomics and protein-protein interaction network data to prioritize the high-confidence GBM surfaceome signature.ResultsAmong the 2,381 significantly dysregulated genes in GBM, 395 genes were classified as surfaceome. Via the integrative analysis, we identified 6 high-confidence GBM molecular signature, HLA-DRA, CD44, SLC1A5, EGFR, ITGB2, PTPRJ, which were significantly upregulated in GBM. The expression of these genes were validated in an independent transcriptomics database, which confirmed their upregulated expression in GBM. Importantly, high expression of CD44, PTPRJ and HLA-DRA is significantly associated with poor disease-free survival. Lastly, using the Drugbank database, we identified several clinically-approved drugs targeting the GBM molecular signature suggesting potential drug repurposing.ConclusionsIn summary, we identified and highlighted the key GBM surface-enriched repertoires that could be biologically relevant in supporting GBM pathogenesis. These genes could be further interrogated experimentally in future studies that could lead to efficient GBM diagnostic/prognostic markers or a therapeutic regimen to treat GBM.

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“…Bu nedenle HA-modifiye ilaç dağıtım sistemlerinin ve nanomateryallerin sindirim sistemi kanserlerinin tedavisinde tümör hücrelerini hedeflemede kullanılabileceği düşünülmektedir. 54,55 Son yıllarda HA, dermatolojide ve kozmetolojide de oldukça ilgi görmektedir. HA, ciltte ve yumuşak bağ dokularında yüksek miktarda bulunmaktadır.…”

Section: Hi̇yalüroni̇k Asi̇tunclassified