Hyaluronic acid and Chondroitin sulfate from marine and terrestrial sources: Extraction and purification methods

Abdallah, Maha M.; Fernández, Naiara; Matias, Ana A.; Bronze, Maria Rosário

doi:10.1016/j.carbpol.2020.116441

Cited by 111 publications

(86 citation statements)

References 107 publications

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“…Moreover, the viscosity of chitosan extracted from fungi is lower than that of crustaceous chitosan (Żukiewicz-Sobczak et al, 2015). Recent studies have demonstrated that different sources and separation methods may result in variances in the purity, molecular weight, and substituents of hyaluronic acid and chondroitin sulfate, which subsequently affect their bioactivities (Abdallah et al, 2020). Chang et al reported that chitosan extracted from Auricularia sp.…”

Section: Structural Instability Of Polysaccharidesmentioning

confidence: 99%

Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Lin

et al. 2020

Front. Bioeng. Biotechnol.

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Ocular drug delivery is one of the most challenging issues in ophthalmology because of the complex physiological structure of the eye. Polysaccharide-based nanomaterials have been extensively investigated in recent years as ideal carriers for enhancing the bioavailability of drugs in the ocular system because of their biocompatibility and drug solubilization. From this perspective, we discuss the structural instability of polysaccharides and its impact on the synthesis process; examine the potential for developing bioactive polysaccharide-based ocular drug nanocarriers; propose four strategies for designing novel drug delivery nanomaterials; and suggest reviewing the behavior of nanomaterials in ocular tissues.

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Section: Structural Instability Of Polysaccharidesmentioning

confidence: 99%

Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Lin

et al. 2020

Front. Bioeng. Biotechnol.

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“…Glycosaminoglycan (GAGs) are multifunctional polysaccharides composed of repeating disaccharide units that may change the form of sulfation and epimerization, which determines different functions of protein recognition and biological activities of these compounds [72,73]. Two important groups of complex heteropolysaccharides belonging to the class of GAGs are chondroitin sulfate (CS) and hyaluronic acid (HA).…”

Section: Glycosaminoglycans-chondroitin Sulfate and Hyaluronic Acidmentioning

confidence: 99%

“…Some studies have revealed that CS has immunomodulatory and anti-inflammatory properties in several diseases [80,81], highlighting the promising effects of CS reducing symptoms and improving function in osteoarthritis patients, which is one of the consequences of RA in advanced phases [82,83]. According to Abdallah et al [72] compiled in a recent review, CS can be extracted from cartilage, head, skeleton, fins, and skin from different marine animals such as sharks, salmon, zebrafish, and other species of fish, squid, ray, and octopus. Still, the primary marine source in commercial terms is shark cartilage.…”

Section: Glycosaminoglycans-chondroitin Sulfate and Hyaluronic Acidmentioning

confidence: 99%

“…The human body is found in higher concentrations in connective tissues such as synovial fluid, the vitreous humor of the eyeball, and the umbilical cord [87]. HA from marine sources can be extracted mainly from the eyeball and liver of swordfish, shark, mollusk bivalves, stingray, and tuna [72,87]. HA is widely used in the biomedical sector for the production of hydrogels that can be used as long-term low-dose drug delivery vehicles [88,89], with an input for the development of new biomaterials applied to wound healing [90] and tissue culture scaffolds [88,91,92].…”

Section: Glycosaminoglycans-chondroitin Sulfate and Hyaluronic Acidmentioning

confidence: 99%

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Marine-Derived Biologically Active Compounds for the Potential Treatment of Rheumatoid Arthritis

et al. 2020

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Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease with a prevalence rate of up to 1% and is significantly considered a common worldwide public health concern. Commercially, several traditional formulations are available to treat RA to some extent. However, these synthetic compounds exert toxicity and considerable side effects even at lower therapeutic concentrations. Considering the above-mentioned critiques, research is underway around the world in finding and exploiting potential alternatives. For instance, marine-derived biologically active compounds have gained much interest and are thus being extensively utilized to confront the confines of in practice counterparts, which have become ineffective for 21st-century medical settings. The utilization of naturally available bioactive compounds and their derivatives can minimize these synthetic compounds’ problems to treat RA. Several marine-derived compounds exhibit anti-inflammatory and antioxidant properties and can be effectively used for therapeutic purposes against RA. The results of several studies ensured that the extraction of biologically active compounds from marine sources could provide a new and safe source for drug development against RA. Finally, current challenges, gaps, and future perspectives have been included in this review.

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“…For example, HA is involved in healing wounds, tissue repair and regeneration, organization of the ECM, lubrication of the joints, regulation of the cell adhesion and motility through receptors that interact with the cytoskeleton, angiogenesis by mediating cell proliferation, cell differentiation and cell migration [24]. Furthermore, HA also has applications in regenerating tissues, cosmetics, optical surgery and has immunomodulatory, anticancer and anti-proliferative properties [25,26]. Anticancer mechanisms in the naked mole rat.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronan as a Prominent Biomolecule with Numerous Applications in Medicine

Valachová

Šoltés

2021

IJMS

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Hyaluronan (HA) is a natural glycosaminoglycan present in many tissues of all vertebrates. HA has various biological functions, which are dependent on its molar mass. High-molar-mass HA has anti-angiogenic, immunosuppressive and anti-inflammatory properties, while low-molar-mass HA has opposite effects. HA has also antioxidative properties, however on the other hand it can be readily degraded by reactive oxygen species. For many years it has been used in treatment of osteoarthritis, cosmetics and in ophthalmology. In the last years there has been a growing interest of HA to also be applied in other fields of medicine such as skin wound healing, tissue engineering, dentistry and gene delivery. In this review we summarize information on modes of HA administration, properties and effects of HA in various fields of medicine including recent progress in the investigation of HA.

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Hyaluronic acid and Chondroitin sulfate from marine and terrestrial sources: Extraction and purification methods

Cited by 111 publications

References 107 publications

Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Marine-Derived Biologically Active Compounds for the Potential Treatment of Rheumatoid Arthritis

Hyaluronan as a Prominent Biomolecule with Numerous Applications in Medicine

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