2022
DOI: 10.3390/bios12010028
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Hyaluronic Acid Allows Enzyme Immobilization for Applications in Biomedicine

Abstract: Enzymes are proteins that control the efficiency and effectiveness of biological reactions and systems, as well as of engineered biomimetic processes. This review highlights current applications of a diverse range of enzymes for biofuel production, plastics, and chemical waste management, as well as for detergent, textile, and food production and preservation industries respectively. Challenges regarding the transposition of enzymes from their natural purpose and environment into synthetic practice are discuss… Show more

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Cited by 8 publications
(6 citation statements)
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“…Hyaluronic acid, a linear anionic polysaccharide, is a major macromolecular component of the extracellular matrix in the most connective tissues. Due to its biocompatible, biodegradable and bioresorbable nature, limited immunogenicity, recognized by cell surface receptors, its flexible and unique viscoelasticity properties, hyaluronic acid has been extensively studied in recent years for biomedical applications [162][163][164]. This biopolymer is useful in medicine for the treatment of diverse pathological situations such as arthritis but is also used in drug delivery and tissue engineering [165,166].…”
Section: Hyaluronic Acidmentioning
confidence: 99%
“…Hyaluronic acid, a linear anionic polysaccharide, is a major macromolecular component of the extracellular matrix in the most connective tissues. Due to its biocompatible, biodegradable and bioresorbable nature, limited immunogenicity, recognized by cell surface receptors, its flexible and unique viscoelasticity properties, hyaluronic acid has been extensively studied in recent years for biomedical applications [162][163][164]. This biopolymer is useful in medicine for the treatment of diverse pathological situations such as arthritis but is also used in drug delivery and tissue engineering [165,166].…”
Section: Hyaluronic Acidmentioning
confidence: 99%
“… 15 The excellent catalytic repertoire of extant natural enzymes is attributed to the unique chemical composition and three-dimensional pocket of their active sites, as a result of long-term evolutionary process. 16 , 17 Owing to the extraordinary catalytic efficiency and outstanding stereoselectivity, enzymes have been broadly applied in the fields of bioengineering, 18 , 19 , 20 , 21 biomedicine, 22 , 23 , 24 food production, 25 , 26 etc. However, the large-scale practical applications of enzymes are restricted.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, through the design of immobilization methods and carrier materials, enzyme catalytic activity and substrate specificity can be retained to a great extent. In recent years, well-developed immobilized enzymes have been widely used in the food industry [ 3 , 4 ], environmental protection [ 5 ], biomedicine [ 6 , 7 , 8 ], and other fields [ 9 ].…”
Section: Introductionmentioning
confidence: 99%