Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging

Paclitaxel-loaded hyaluronan solid nanoemulsions for enhanced treatment efficacy in ovarian cancer

“…The CD44-HA ligand-receptor pair is well known for its active tumor-targeting efficacy in cancer therapy. 14,[20][21][22][23] The targeting delivery systems such as nanoparticles, polymeric micelles, liposomes, emulsions, and nanogels with HA provide several advantages as drug carriers in both active and passive targeting of tumor receptors for drug delivery. 8,10,24,25 However, there are still several limitations, including low tumor-targeting efficacy, low bioavailability, undesirable tissue distribution, low drug loading dose, the need for relatively large injection volumes, low antitumor efficacy, unpredictable toxicity, and an initial drug release burst.…”

The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin

“…5,6 Therefore, active tumor-targeted PMs, which could be internalized by specific receptor-mediated endocytosis in tumor cells, and achieve a higher chemotherapy efficacy and are beneficial in reducing the side effects in normal tissues, have been extensively focused toward cancer treatment. 7,8 To achieve active targeting, various specific targeting ligands, such as folic acid, 9,10 peptide, [11][12][13] hyaluronic acid, [14][15][16] and other ligands, 17 have been grafted onto the surface of PMs, and then the PMs specifically interact with the receptor expressed on target cancer cells.…”

“…CD44 receptors are overexpressed on the surface of various tumor cells and play an important role in cancer cell proliferation, migration, and invasion. 8,22 Apart from this, HA has a functional group for chemical modification, and many studies have proved that conjugation HA with cytotoxic agent could significantly enhanced the efficiency of anticancer agents. 20 Therefore, based on the above features, HA-based polymers have been applied as promising active targeting vehicles for cancer therapy, due to their biocompatibility, biodegradability, and specific CD44 receptor-mediated active targeting on tumor cells.…”

A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging

“…12 Importantly, HA can specifically bind to cancer cells that overexpress CD44, 13 resulting in the belief that CD44-HA interaction may provide a new approach to the targeted diagnosis and treatment of specific cancers. 14 Respecting these advantages of HA, we synthesized HAmodified SWCNTs (SWCNTs-HA) to further prepare the Gd 3+ -based CAs in this work. Moreover, in order to achieve the pairing of a therapeutic agent with a diagnostic technique, anticancer drugs would be also loaded to the nanocarriers.…”