Hyaluronan biofilms reinforced with partially deacetylated chitin nanowhiskers: Extraction, fabrication, in-vitro and antibacterial properties of advanced nanocomposites

Abdel-Rahman, Rasha M.; Abdel-Mohsen, A.M.; Zbončák, Marek; Franková, Jana; Lepcio, Petr; Kobera, Libor; Steinhart, Miloš; Pavliňák, David; Spotaz, Z.; Sklenářévá, R.; Brus, Jiřı́; Jančář, J.

doi:10.1016/j.carbpol.2020.115951

Cited by 28 publications

(33 citation statements)

References 45 publications

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“…Blends of hydrophobic polymers and nanochitins, both ChNFs and ChNCs, have also been attempted. − Acrylic resin (AR) and TEMPO-oxidized ChNCs (TO-ChNCs) have been blended (AR/TO-ChNC) and further laminated with biaxially oriented PP (BOPP) aiming at high barrier properties for packaging applications. The initial blended suspension gelled when only 3 wt % of TO-ChNCs was used, which is likely a result of multiple hydrogen bonding taking place among the blend’s components, forming an interconnected and more rigid network.…”

Section: Consolidation Phenomena In Materials Developmentmentioning

confidence: 99%

Deconstruction and Reassembly of Renewable Polymers and Biocolloids into Next Generation Structured Materials

et al. 2021

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This review considers the most recent developments in supramolecular and supraparticle structures obtained from natural, renewable biopolymers as well as their disassembly and reassembly into engineered materials. We introduce the main interactions that control bottom-up synthesis and top-down design at different length scales, highlighting the promise of natural biopolymers and associated building blocks. The latter have become main actors in the recent surge of the scientific and patent literature related to the subject. Such developments make prominent use of multicomponent and hierarchical polymeric assemblies and structures that contain polysaccharides (cellulose, chitin, and others), polyphenols (lignins, tannins), and proteins (soy, whey, silk, and other proteins). We offer a comprehensive discussion about the interactions that exist in their native architectures (including multicomponent and composite forms), the chemical modification of polysaccharides and their deconstruction into high axial aspect nanofibers and nanorods. We reflect on the availability and suitability of the latter types of building blocks to enable superstructures and colloidal associations. As far as processing, we describe the most relevant transitions, from the solution to the gel state and the routes that can be used to arrive to consolidated materials with prescribed properties. We highlight the implementation of supramolecular and superstructures in different technological fields that exploit the synergies exhibited by renewable polymers and biocolloids integrated in structured materials.

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Section: Consolidation Phenomena In Materials Developmentmentioning

confidence: 99%

Deconstruction and Reassembly of Renewable Polymers and Biocolloids into Next Generation Structured Materials

et al. 2021

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“…In vitro biological experiments on PHEMA, P(HEMA-DMAEMA), and PHEMA@γ-Fe 2 O 3 hydrogels were conducted with human osteoblast-like cells of SAOS-2 line, a representative of hard connective tissues. This cell type is used to evaluate material biocompatibility [ 36 , 37 ]. We used this cell type because one of the possible utilizations of the PHEMA-based materials is in bone tissue reconstruction.…”

Section: Resultsmentioning

confidence: 99%

Magnetic Superporous Poly(2-hydroxyethyl methacrylate) Hydrogel Scaffolds for Bone Tissue Engineering

et al. 2021

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Magnetic maghemite (γ-Fe2O3) nanoparticles obtained by a coprecipitation of iron chlorides were dispersed in superporous poly(2-hydroxyethyl methacrylate) scaffolds containing continuous pores prepared by the polymerization of 2-hydroxyethyl methacrylate (HEMA) and ethylene dimethacrylate (EDMA) in the presence of ammonium oxalate porogen. The scaffolds were thoroughly characterized by scanning electron microscopy (SEM), vibrating sample magnetometry, FTIR spectroscopy, and mechanical testing in terms of chemical composition, magnetization, and mechanical properties. While the SEM microscopy confirmed that the hydrogels contained communicating pores with a length of ≤2 mm and thickness of ≤400 μm, the SEM/EDX microanalysis documented the presence of γ-Fe2O3 nanoparticles in the polymer matrix. The saturation magnetization of the magnetic hydrogel reached 2.04 Am2/kg, which corresponded to 3.7 wt.% of maghemite in the scaffold; the shape of the hysteresis loop and coercivity parameters suggested the superparamagnetic nature of the hydrogel. The highest toughness and compressive modulus were observed with γ-Fe2O3-loaded PHEMA hydrogels. Finally, the cell seeding experiments with the human SAOS-2 cell line showed a rather mediocre cell colonization on the PHEMA-based hydrogel scaffolds; however, the incorporation of γ-Fe2O3 nanoparticles into the hydrogel improved the cell adhesion significantly. This could make this composite a promising material for bone tissue engineering.

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“…Antibacterial ability was also observed by Makvandi et al [50], who did not show the antibacterial properties of HA against Gram(+) S. aureus, Bacillus subtilis, and Gram(−) Pseudomonas aeruginosa, E. coli, but introduced Ag particles into the coatings. In turn, Abdelrahman et al [51] observed the antibacterial effect only after the combination of HA with Ch. Similarly, Chen et al [52] made a similar report for HA adduct obtained by N-halogenation reaction of HA.…”

Section: Microbiological Testsmentioning

confidence: 97%

The Influence of Polysaccharides/TiO2 on the Model Membranes of Dipalmitoylphosphatidylglycerol and Bacterial Lipids

et al. 2022

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The aim of the study was to determine the bactericidal properties of popular medical, pharmaceutical, and cosmetic ingredients, namely chitosan (Ch), hyaluronic acid (HA), and titanium dioxide (TiO2). The characteristics presented in this paper are based on the Langmuir monolayer studies of the model biological membranes formed on subphases with these compounds or their mixtures. To prepare the Langmuir film, 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DPPG) phospholipid, which is the component of most bacterial membranes, as well as biological material-lipids isolated from bacteria Escherichia coli and Staphylococcus aureus were used. The analysis of the surface pressure-mean molecular area (π-A) isotherms, compression modulus as a function of surface pressure, CS−1 = f(π), relative surface pressure as a function of time, π/π0 = f(t), hysteresis loops, as well as structure visualized using a Brewster angle microscope (BAM) shows clearly that Ch, HA, and TiO2 have antibacterial properties. Ch and TiO2 mostly affect S. aureus monolayer structure during compression. They can enhance the permeability of biological membranes leading to the bacteria cell death. In turn, HA has a greater impact on the thickness of E. coli film.

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Hyaluronan biofilms reinforced with partially deacetylated chitin nanowhiskers: Extraction, fabrication, in-vitro and antibacterial properties of advanced nanocomposites

Cited by 28 publications

References 45 publications

Deconstruction and Reassembly of Renewable Polymers and Biocolloids into Next Generation Structured Materials

Deconstruction and Reassembly of Renewable Polymers and Biocolloids into Next Generation Structured Materials

Magnetic Superporous Poly(2-hydroxyethyl methacrylate) Hydrogel Scaffolds for Bone Tissue Engineering

The Influence of Polysaccharides/TiO2 on the Model Membranes of Dipalmitoylphosphatidylglycerol and Bacterial Lipids

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