Hyaluronan Biodegradable Scaffold for Small-caliber Artery Grafting: Preliminary Results in an Animal Model

Lepidi, Sandro; Grego, Franco; Vindigni, Vincenzo; Zavan, Barbara; Tonello, C; Deriu, Giovanni P.; Abatangelo, Giovanni; Cortivo, Roberta

doi:10.1016/j.ejvs.2006.02.012

Cited by 61 publications

(45 citation statements)

References 18 publications

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“…This suggests potential application of HA scaffolds in cell encapsulation and tissue regeneration (Ji et al, 2006). In another study, Lepidi et al (2006) implanted a HA-based graft (HYAFF 11™ tube, diameter 2 mm, length 1.5 cm) in an end-to-end fashion in the abdominal aorta of rats and allowed for 7, 21, and 90 days. The data indicated that the HA-based graft allowed complete regeneration of a newly formed vascular tube in which all the cellular and extracellular components are present and organized in a well-defined architecture similar to the native artery (Lepidi et al, 2006).…”

Section: Hyaluronan In Drug Deliverymentioning

confidence: 98%

The magic glue hyaluronan and its eraser hyaluronidase: A biological overview

2007

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Section: Hyaluronan In Drug Deliverymentioning

confidence: 98%

The magic glue hyaluronan and its eraser hyaluronidase: A biological overview

2007

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“…Also, a supportive effect on differentiated cell phenotype has been reported for adult cardiomyocytes grown on a HA containing substrate [52]. Due to its viscoelastic properties HA has been employed in experimental and clinical studies on soft tissue repair, mostly involving cartilage, but also other tissues including heart valves [53][54][55][56]. In most applications it appears attractive to support the HA matrix by adding other biological or synthetic ECM components [57,58] to yield the desired combination of compressive and tensile characteristics and at the same time beneficial bioactivity of the resulting ECM [6,42,59].…”

Section: Hyaluronic Acidmentioning

confidence: 98%

Myocardial tissue engineering: the extracellular matrix☆

Akhyari¹,

Kamiya²,

Haverich³

et al. 2008

European Journal of Cardio-Thoracic Surgery

115

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More than a decade after the first reports on successful three-dimensional cardiac cell culture for experimental and potential therapeutic application, the interest and experimental efforts in the field of myocardial tissue engineering continues to grow. The hope that tissue cultures may one day act as graft substitute for malfunctioning myocardium continues to drive current scientific activity. Against this background interest seem to have progressively shifted towards the aim of engineering single tissue components. Accordingly, elements of the extracellular matrix (ECM) have gained increasing attention as potentially crucial mediators in developing and maintaining the characteristics of three-dimensional cardiac cell cultures. The ECM is now no longer regarded as merely a scaffold for developing tissue, a concept that is widely acknowledged in modern tissue engineering. The understanding of the role of precursor and stem cells has highlighted new complicated aspects of cell proliferation and differentiation and ECM proves to play an important role in providing essential signals to influence major intracellular pathways such as proliferation, differentiation and cell metabolism. Furthermore, progress in biochemical engineering has provided the perspective of application of synthetic ECM-linked molecules with bioactive potential. With the advent and continuous refinement of cell removal techniques, a new class of native acellular ECM has emerged with some striking advantages. The presently available ECM materials aim to closely resemble the in vivo microenvironment by acting as an active component of the developing tissue construct. It is therefore not surprising that most of the focus in myocardial tissue engineering has been on cell-matrix interaction, for both naturally derived and synthetic ECM. This article provides a review of established models of myocardial tissue engineering with respect to the employed ECM materials including current frontiers in material development.

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“…The degradation products, namely oligosaccharides, are implicated in several biological processes, including angiogenesis, cell differentiation and morphogenesis, cell migration and aggregation, and the maturation of mesenchymal progenitor cells [22]. HYAFF11 has been widely used in both clinical products and experimental studies in a variety of forms, such as nonwoven fleeces, membranes, sponges, cylinders, and tubes, and has demonstrated efficacy in many studies when used as scaffolds in the reconstruction of skin [23,24], cartilage [25][26][27][28], bone [27,[29][30][31], ligament [32,33], intervertebral disc [34], nerve guides [35], small-diameter vascular substitutes [36,37], and hepatic tissue [38].…”

Section: Introductionmentioning

confidence: 99%