Humulane and Germacrane Sesquiterpenes from <i>Ferula lycia</i>

Alkhatib, Racha; Hennebelle, Thierry; Joha, Sami; Roumy, Vincent; Güzel, Yelda; Biabiany, Murielle; Idziorek, Thierry; Preudhomme, Claude; Quesnel, Bruno; Şahpaz, Sevser; Bailleul, François

doi:10.1021/np900827a

Cited by 12 publications

(14 citation statements)

References 24 publications

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“…persica and F. halophila, as well as the hexane extract of F. elaeochytris, were assigned to be more active than methanolic extracts of the plants [36][37][38]. In addition, the acetylcholinesterase inhibitory activities of coumarin derivatives from F. gummosa and F. asafoetida species were determined, previously [30][31][32][33][34][35][36][37][38][39][40][41]. In the current study, the chloroform extracts of F. caspica and F. halophila that could be expected to contain some coumarin derivatives weren't found to be as active as methanol extracts of the plants compared to standard donepezil.…”

Section: Discussionmentioning

confidence: 99%

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Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Kahraman¹,

Baysal²,

Cankaya³

et al. 2019

jrp

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The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Peşmen. Antioxidant capacities and total phenolic contents of the plants' extracts were tested by DPPH radical scavenging assay and Folin Ciocalteu assay, respectively. Acetylcholinesterase inhibitory activities of the extracts were investigated with the aim of indicating whether there was a correlation with their antioxidant capacities. Different quinic acid and flavonoid derivatives which may be responsible for the activities of the extracts were detected using LC-MS screening in the methanol extracts. The methanol extract from the aerial parts of F. caspica was found to show most antioxidant capacity and acetylcholinesterase inhibitory activity.

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Section: Discussionmentioning

confidence: 99%

“…Especially, sesquiterpene and coumarin derivatives were isolated from apolar extracts of Ferula species [29][30][31][32]. Studies on the polar metabolites are unfortunately limited.…”

Section: Lc-ms Analysis Of Phenolic Compoundsmentioning

confidence: 99%

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Kahraman¹,

Baysal²,

Cankaya³

et al. 2019

jrp

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“…[27], F. orientalis [28], F. rigidula [29], F. haussknechtii [30] and F. lycia Boiss. [31] from Subgenus Peucedanoides yield mainly daucane, apiene and germacrane sesquiterpene esters. Because of the presence of multiple chiral centers and variety of structural features such as mono-, di-, tricylic skeletons that vastly enhance their structural diversity, utilization of the sesquiterpenoid compounds as chemotaxonomic markers provide an unparalleled advantage over the use of classical phenolic chemotaxonomic markers such as flavonoids.…”

Section: Introductionmentioning

confidence: 99%

A New Ferula (Apiaceae) Species from Southwest Anatolia: Ferula pisidica Akalın & Miski

Akalin

Tuncay

Olcay

et al. 2020

Plants

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Ferula pisidica is a novel endemic species found in the vicinity of Karaman province of inner Mediterranean Region of Turkey. F. pisidica is morphologically distinct from F. haussknechtii and F. brevipedicellata by habit, sheaths, terminal leaf lobes, and mericarp size as well as by chemotaxonomic differences. The new species is described by morphological, carpological, ecological and phytochemical characteristics. Its relationships with the other related species and proposed conservation status will be reviewed.

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“…4 Monoterpenes, sesquiterpenes (especially daucanes, humulanes, and guaianes type sesquiterpene esters, sesquiterpene lactones), coumarins were found to be the main constituents of the Ferula genus by phytochemical studies. [5][6][7][8] Phenylpropanoid, sulphur containing derivates, triterpenes and their glycosides were also reported. [9][10][11] Recent pharmacological research has demonstrated that different extracts of Ferula species contain sesquiterpene derivatives have in particular proven to be cytotoxic on several cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Daucane Sesquiterpene Esters Isolated From Endemic Ferula tenuissima HUB. MOR& PEŞMEN

Aydoğan¹,

Baykan²,

Bütüner³

2018

tjps

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Objectives: Phytochemical study of endemic Ferula tenuissima roots and determination of the cytotoxic activity of pure compounds on PC-3. Materials and Methods: Air-dried and powdered roots of F. tenuissima (1 kg) were extracted respectively with n-hexane, chloroform (CHCl3) and methanol (MeOH) (3x2 L, each) by sonication at 30 ºC, for 24h. The extracts were then filtered. The solvents separately evaporated under reduced pressure to dryness. Compounds were isolated by chromatographic methodes and structures of compounds were determined by spectral methodes (1D-, 2D NMR and LC-MS). Compounds were tested for their cytotoxic activities versu PC-3 cell line by WST assay. Results: Phytochemical investigation of dried roots of endemic F. tenuissima performed and three sesquiterpene esters were isolated. As teferidin, ferutinin and elaocyhtrin-A; daucane-type sesquiterpenes were identified. In the bioactivity study, Ferutinin exhibitited the highest cytotoxic activity with 19.7 µM IC50 value. Conclusion: The results indicate that the main compounds of Ferula tenuissima roots are daucane sesquiterpenes and ferrutinin has potential effect on PC-3 cells.

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Humulane and Germacrane Sesquiterpenes from Ferula lycia

Cited by 12 publications

References 24 publications

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

A New Ferula (Apiaceae) Species from Southwest Anatolia: Ferula pisidica Akalın & Miski

Cytotoxic Activity of Daucane Sesquiterpene Esters Isolated From Endemic Ferula tenuissima HUB. MOR& PEŞMEN

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