Humoral immunity to cow’s milk proteins and gliadin within the etiology of recurrent aphthous ulcers?

Besu, Irina; Janković, Ljiljana; Magdu, IU; Konić-Ristić, Aleksandra; Rašković, Sanvila; Juranić, Zorica D.

doi:10.1111/j.1601-0825.2009.01595.x

Cited by 24 publications

(27 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For that reason, the importance of examination antibodies against caseins or whey proteins for patients with RAU is substantial. The possible good effect of CMP-free diet at the prevention of ulcerations in patients with RAU with enhanced immunoreactivity to SCMP is supported by our earlier report (5). Prevention is based on the use of only appropriate restriction diet.…”

Section: Discussionmentioning

confidence: 56%

The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers

Besu

Janković

Konić-Ristić

et al. 2012

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 56%

The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers

Besu

Janković

Konić-Ristić

et al. 2012

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…In that study, 20 RAS patients with celiac disease were excluded and placed on a gluten‐free diet; 5 (25%) of these patients showed a favorable response to gluten withdrawal and had a positive gluten challenge. Besu et al . studied the association between RAS and cow's milk protein, reporting significantly high levels of serum antibodies to cow's milk protein in 32 of 50 RAS patients.…”

Section: Discussionmentioning

confidence: 99%

Is there a role of food additives in recurrent aphthous stomatitis? A prospective study with patch testing

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The levels of serum anti-melanin, or anti-tyrosinase IgA, IgG and IgM autoantibodies were determined by ELISA [21]. (Two forms of tyrosinase exist: intracellular membrane bound form -consisting of inner, transmembrane and cytoplasmic domain-, and soluble form.…”

Section: Methodsmentioning

confidence: 99%

“…In our previous articles we proved that many of food antigens (like gliadin from wheat, cow’s milk proteins, phytohemagglutinin from red beans), induced some kind of immune-mediated molecules - synthesis of various class of immunoglobulins, IgG, IgA, IgM [19-21]. Similarly to this it was easy to propose that the edible mushrooms as the rich source of tyrosinase and of melanin, after the consummation, could induce immunity to mentioned molecular structures.…”

Section: Introductionmentioning

confidence: 99%

Immunity to melanin and to tyrosinase in melanoma patients, and in people with vitiligo

Đorđić

Matić

Filipovic-Ljeskovic

et al. 2012

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundThe aim of this study was to determine the presence and the intensity of humoral immunity to melanoma-associated antigens: tyrosinase and melanin, in patients with melanoma, in persons with vitiligo and in control healthy people.MethodsThe study involved 63 patients with melanoma and 19 persons with vitiligo. Control group consisted up to 41 healthy volunteers. Mushroom tyrosinase and synthetic melanin were used as the antigens.ResultsELISA test showed significantly (p < 0.0000004 and p < 0.04) lower levels of IgM anti-tyrosinase autoantibodies, in melanoma and vitiligo patients respectively, compared to controls.Although there was no significant difference between the levels of IgA anti-melanin autoantibodies in melanoma or vitiligo patients in comparison with controls, the enhanced concentrations of anti-melanin IgA autoantibodies were preferentially found in melanoma patients with metastatic disease. Significantly high percentage in the Fc alphaRI (CD89) positive cells was determined in melanoma patients (p < 0.002 and p < 0.008) in comparison to that found in healthy people or in patients with vitiligo, in the already mentioned order, pointing that IgA dependent cellular cytotoxicity is not important for the immune action against melanoma, even more that it is included in some immune suppression.Levels of IgG autoantibodies to mentioned antigens in melanoma patients although low were not significantly lower from controls. These findings analyzed together with the statistically significant low percentage of FcgammaRIII, (CD16) positive immunocompetent cells (p < 0.0007 and p < 0.003), which was found in patients with melanoma compared with healthy or vitiligo people respectively, and statistically significant low percentage of (CD16 + CD56+) natural killer (NK) cells (p < 0.005) found in melanoma patients in comparison to healthy controls pointed to the low probability for anti-melanoma IgG mediated, antibody mediated cellular cytotoxicity, (ADCC) and NK cytotoxicity. Moreover the ratio of the percentages of granulocytes and percentage of lymphocytes was statistically higher in patients with melanoma in relation to healthy people as well as to people with vitiligo (p < 0.0007 and p < 0.05 respectively).ConclusionAutoantibodies to tyrosinase and to melanin which are found even in healthy people, point that consummation of edible mushrooms that carry the antigen tyrosinase and melanin, could influence the humoral anti-melanoma immune response.Levels of different immunoglobulin classes of anti-melanin and anti-tyrosinase antibodies varied depending on the presence and the stage of studied diseases. Besides, the statistically enhanced ratio of the percentages of granulocytes and percentage of lymphocytes, together with statistically decreased percentage of NK cells is found in analyzed melanoma patients.

show abstract

Humoral immunity to cow’s milk proteins and gliadin within the etiology of recurrent aphthous ulcers?

Abstract: These results indicate the strong association between high levels of serum anti-CMP IgA, IgG and IgE antibodies and clinical manifestations of recurrent aphthous ulcers.

Cited by 24 publications

References 15 publications

The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers

The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers

Is there a role of food additives in recurrent aphthous stomatitis? A prospective study with patch testing

Immunity to melanin and to tyrosinase in melanoma patients, and in people with vitiligo

Contact Info

Product

Resources

About