The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers

Abstract

These results indicate the strong association between high levels of serum anti-SCMP IgA, IgG, and IgE antibodies, especially to caseins: α-, β-, and κ-casein from cow's milk and clinical manifestations of RAU. Serum immunity to the whey proteins in subjects with RAU was not in so high percentage expressed.

Good tolerance to goat's milk in patients with recurrent aphthous ulcers with increased immunoreactivity to cow's milk proteins

“…, because ewe's and goat's milk are similar to cow's milk but with evident reduction in α‐casein fraction. In our earlier study , we point to the strong association between the presence of high levels of serum IgG and IgE antibodies, especially to α ‐ and β ‐ and κ ‐casein from CMP and clinical manifestations of RAU.…”

“…Elevated humoral immunity to whey proteins was also (but not so frequently) found in these subjects with RAU . Because of the absence of β‐lactoglobulin in human milk, this protein has been considered the most important cow's milk allergen for a long time .…”

“…Sera of these subjects were tested earlier to CMP , 36 of them (RAU+) had increased humoral IgA, IgG, or IgE immunoreactivity to CMP, and 14 of them (RAU‐) did not have increased humoral immunity to CMP. Later, these subjects were tested to specific cow's milk proteins (SCMP), constituents of cheese or of whey . The results of this investigation indicate the strong association between high levels of serum anti‐SCMP IgA, IgG, and IgE antibodies, especially to caseins: α‐, β‐, and κ‐casein from cow's milk and clinical manifestations of RAU .…”

“…Later, these subjects were tested to specific cow's milk proteins (SCMP), constituents of cheese or of whey . The results of this investigation indicate the strong association between high levels of serum anti‐SCMP IgA, IgG, and IgE antibodies, especially to caseins: α‐, β‐, and κ‐casein from cow's milk and clinical manifestations of RAU .…”

“…Results from work of Besu et al. showed that the levels of anticasein CMP IgA, IgG, and IgE antibodies were significantly higher and more frequently found in subjects with RAU in comparison with healthy controls. This evidence of caseins immunogenicity is in accordance with several independent studies which have demonstrated that the casein fraction has an important antigenic potential , and it is proven that caseins maintain the capability of binding IgEs even after strong denaturating processes .…”