Humoral Immune Response to Islet Autoantigens in Japanese Patients with Type 1 Diabetes

Kawasaki, Eiji; Kuriya, Genpei; Satoh, Tsuyoshi; Fujishima, Keiichiro; Moriuchi, Akira; Fukushima, Keiko; Ozaki, Masako; Abiru, Norio; Yamasaki, Hironori; Eguchi, Katsumi

doi:10.1196/annals.1447.027

Cited by 5 publications

(2 citation statements)

References 5 publications

(7 reference statements)

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“…GAD antibody and islet cell antibody were positive in 85% and 49% of type 1 diabetic patients, respectively (Table 3). The frequency of GAD antibody was relatively higher than that reported in Japanese type 1 diabetic patients (63–74%) 3 . GAD antibody sero‐conversion was observed in 7 patients who had no detectable GAD antibody before starting IFN therapy.…”

Section: Resultscontrasting

confidence: 53%

Classification and characteristics of interferon‐related diabetes mellitus in Japan

Muraishi

Sasaki

Kato

et al. 2011

Hepatology Research

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Section: Resultscontrasting

confidence: 53%

Classification and characteristics of interferon‐related diabetes mellitus in Japan

Muraishi

Sasaki

Kato

et al. 2011

Hepatology Research

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“…Others have reported that slowly progressive type 1 diabetic patients 14,15 or females 7,16 are more likely to be GADA-positive than acute-onset type 1 diabetes or males, respectively. Univariate analysis showed that GADA positivity is more likely in those with slowly progressive type 1 diabetes (OR 2.24, 95% confidence interval 1.14-4.41, P = 0.020), but not females (Table S2).…”

Section: Interaction Of Duration Of Diabetes and Age Of Onset On Antimentioning

confidence: 99%

Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma‐associated antigen‐2 and zinc transporter 8

Kawasaki

Oikawa

Okada³

et al. 2020

J of Diabetes Invest

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Aims/Introduction: This study aimed to investigate the dynamics associated with autoantibodies to insulinoma-associated antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A) relating to the onset age and disease duration in patients with type 1 diabetes. Methods: Using bridging-type enzyme-linked immunosorbent assay, IA-2A, ZnT8A and glutamic acid decarboxylase autoantibodies were evaluated in 269 patients with type 1 diabetes (median onset age 18.2 years, range 0.8-86 years; median diabetes duration 7 years, range 0-58 years). We then compared the prevalence of these autoantibodies among the different age groups, along with the duration of diabetes using the Cochran-Armitage trend test and multivariate logistic regression analysis. Results: The prevalence of IA-2A, ZnT8A and glutamic acid decarboxylase autoantibodies in patients with duration of ≤3 years was 41.1, 36.7 and 72.2%, respectively, with 80.0% expressing one or more of these autoantibodies. This prevalence declined according to the disease duration (P < 0.005). Both IA-2A and ZnT8A were more frequently observed in younger patients, whereas glutamic acid decarboxylase autoantibodies was more common in older patients. Multivariate logistic regression analysis showed that there was a significant interaction between the onset age and duration of diabetes in patients diagnosed when aged ≤10 years regarding all anti-islet autoantibodies (P < 0.05). However, for patients diagnosed in the middle tertile (aged 11-30 years), the interaction was significant only for ZnT8A, and for those with late-onset diabetes (aged ≥31 years) only for IA-2A. Conclusions: The current study showed that the rate of disappearance of anti-islet autoantibodies is faster in patients aged ≤10 years, and that even though both proteins are localized in the insulin granule membrane, humoral autoimmunity to IA-2 and ZnT8 differs according to the age of onset.

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A case of elderly-onset type 1 diabetes mellitus: negative for antiglutamic acid dehydrogenase antibody and positive insulinoma-associated tyrosine phosphatase-like protein-2 antibody

Chiba¹,

Ynie²,

Kimbara³

et al. 2013

Jpn J Geriat

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An 83-year-old Japanese woman given a diagnosis of type 2 diabetes mellitus 3 years previously was hospitalized for markedly elevated plasma glucose (386 mg/dl) and glycated hemoglobin (9.3%) levels. Laboratory study results showed urinary connecting peptide immunoreactivity (CPR) concentrations of 8.9 μg/day and serum CPR levels <0.2 ng/ml before and 0.3 ng/ml 6 min after glucagon administration, indicating decreased insulin secretion. Although antiglutamic acid dehydrogenase (GAD) antibody levels were negative, insulinoma-associated tryrosine phosphatase-like protein-2 (IA-2) antibody levels were positive (50 U/ml), leading to a diagnosis of type 1 diabetes mellitus. Furthermore, human leukocyte antigen (HLA) typing revealed DRB1*0901, a diabetes-susceptibility gene. Intensive insulin therapy was initiated. This was a rare case of elderly-onset type 1 diabetes.

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Humoral Immune Response to Islet Autoantigens in Japanese Patients with Type 1 Diabetes

Cited by 5 publications

References 5 publications

Classification and characteristics of interferon‐related diabetes mellitus in Japan

Classification and characteristics of interferon‐related diabetes mellitus in Japan

Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma‐associated antigen‐2 and zinc transporter 8

A case of elderly-onset type 1 diabetes mellitus: negative for antiglutamic acid dehydrogenase antibody and positive insulinoma-associated tyrosine phosphatase-like protein-2 antibody

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