Humoral immune response in children with iron-deficiency anaemia.

Abstract

of mortality in middle and early old age in the county boroughs of England and Wales. Br J Prev Soc Med 1969 ;23:133-40. 6 Roberts CJ, Lloyd S. Association between mortality from ischaemic heart disease and rainfall The humoral immune response (as shown by plasma immunoglobulin concentrations and antibody response to diphtheria and tetanus toxoids) was evaluated in 14 children with iron-deficiency anaemia and in 24 normal controls. Mean concentrations of haemoglobin and serum iron and mean transferrin saturation were significantly lower in children with iron-deficiency anaemia than in controls. Serum immunoglobulin concentrations were within the normal range in both groups. Two weeks after immunisation with diphtheria and tetanus toxoids the concentrations of IgG increased significantly in both groups. Antibody titres in irondeficient children were similar to those of controls before and after immunisation. The mean T-lymphocyte count was significantly lower in iron-deficient children than that in controls, but the mean B-lymphocyte counts were similar in the two groups. These observations suggest that humoral immunity in children is not affected by iron deficiency and that conventional immunisation programmes would be effective in children with iron-deficiency anaemia.

Decreased Lymphocyte Subsets and K-Cell Activity in Iron Deficiency Anemia

“…To the best of our knowledge there is no previ ous report in the literature on the values of these cells by monoclonal antibodies. The percentage of T lym phocytes (E-rosette-positive) was reported to be de creased [9,[16][17][18][19][20] while the absolute number of these cells was either normal [16,21] or decreased [20]. Our finding of B lymphopenia differs from previous re ports [16,17,21] which described a normal number of these cells in IDA.…”

Immunoglobulin and Iron Deficiency Anemia

“…Sadeghian et al [1] concluded that ''serum immunoglobulin levels did not change in iron deficiency anemia.'' This report is concordant with some previous reports such as the reports by Bagchi et al [2]. However, there are some basic facts to be addressed.…”

Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study

“…Bagchi et al .,[21] also gave similar opinion regarding the effect of ID on HMI in children. Although our results are in contrast to Tang et al .…”