Humoral hypercalcemia associated with gastric carcinoma secreting parathyroid hormone: a case report and review of the literature

Nakajima, Koji; Tamai, Masataka; Okaniwa, Shinji; Nakamura, Yoshiyuki; Kobayashi, Mutsuhiro; Niwa, Tomohiro; Horigome, Naoto; Ito, Nobuo; Suzuki, Satoru; Nishio, Shintaro; Komatsu, Mitsuhisa

doi:10.1507/endocrj.ej12-0406

Cited by 43 publications

(26 citation statements)

References 22 publications

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“…PTHrP has been purified from a human lung cancer cell line [7] and has significant sequence homology with the amino-terminal end of PTH [3, 7–9]. PTHrP is normally synthesized by various tissues and has important physiological roles.…”

Section: Discussionmentioning

confidence: 99%

“…Malignant-associated hypercalcemia (MAH) is classified into four groups: humoral hypercalcemia of malignancy (HHM), local osteolytic hypercalcemia (LOH), excess 1,25(OH) 2 D secretion, and ectopic parathyroid hormone (PTH) secretion. HHM is associated with 80 percent of MAHs and is caused by the effects of the oversecretion of parathyroid hormone-related peptide (PTHrP) [1–3]. Although HHM can essentially be caused by any tumor [1], its induction by cholangiocarcinoma or gastric cancer (GC) is rare [4, 5].…”

Section: Introductionmentioning

confidence: 99%

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Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer

Takeda

Kimura

Nishigaki

et al. 2017

Case Reports in Endocrinology

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Humoral hypercalcemia of malignancy (HHM) is caused by the oversecretion of parathyroid hormone-related peptide (PTHrP) from malignant tumors. Although any tumor may cause HHM, that induced by intrahepatic cholangiocarcinoma (ICC) or gastric cancer (GC) is rare. We report here a 74-year-old male who displayed HHM with both ICC and GC and showed an elevated serum PTHrP level. Treatment of the hypercalcemia with saline, furosemide, elcatonin, and zoledronic acid corrected his serum calcium level and improved symptoms. Because treatment of ICC should precede that of GC, we chose chemotherapy with cisplatin (CDDP) and gemcitabine (GEM). Chemotherapy reduced the size of the ICC and decreased the serum PTHrP level. One year after diagnosis, the patient was alive in the face of a poor prognosis for an ICC that produced PTHrP. Immunohistochemical staining for PTHrP was positive for the ICC and negative for the GC, leading us to believe that the cause of the HHM was a PTHrP-secreting ICC. In conclusion, immunohistochemical staining for PTHrP may be useful in discovering the cause of HHM in the case of two cancers accompanied by an elevated serum PHTrP level. Chemotherapy with CDDP and GEM may be the most appropriate treatment for a PTHrP-secreting ICC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer

Takeda

Kimura

Nishigaki

et al. 2017

Case Reports in Endocrinology

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“…It is well established that detection of asymptomatic cancer can markedly improve the prognosis (4). Many cancers such as breast cancer (5), colon cancer, prostate cancer (6), lung cancer (7), and gastrointestinal (8) and hematological malignancies (9) are associated with hypercalcemia. Therefore, we hypothesized that monitoring blood calcium concentration could be a suitable strategy to detect these types of cancer at an asymptomatic stage.…”

Section: Introductionmentioning

confidence: 99%

Synthetic biology-based cellular biomedical tattoo for detection of hypercalcemia associated with cancer

et al. 2018

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Diagnosis marks the beginning of any successful therapy. Because many medical conditions progress asymptomatically over extended periods of time, their timely diagnosis remains difficult, and this adversely affects patient prognosis. Focusing on hypercalcemia associated with cancer, we aimed to develop a synthetic biology-inspired biomedical tattoo using engineered cells that would (i) monitor long-term blood calcium concentration, (ii) detect onset of mild hypercalcemia, and (iii) respond via subcutaneous accumulation of the black pigment melanin to form a visible tattoo. For this purpose, we designed cells containing an ectopically expressed calcium-sensing receptor rewired to a synthetic signaling cascade that activates expression of transgenic tyrosinase, which produces melanin in response to persistently increased blood Ca 2+. We confirmed that the melanin-generated color change produced by this biomedical tattoo could be detected with the naked eye and optically quantified. The system was validated in wild-type mice bearing subcutaneously implanted encapsulated engineered cells. All animals inoculated with hypercalcemic breast and colon adenocarcinoma cells developed tattoos, whereas no tattoos were seen in animals inoculated with normocalcemic tumor cells. All tumor-bearing animals remained asymptomatic throughout the 38-day experimental period. Although hypercalcemia is also associated with other pathologies, our findings demonstrate that it is possible to detect hypercalcemia associated with cancer in murine models using this cell-based diagnostic strategy.

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“…Although certain types of cancer-such as lung cancer, hepatocellular carcinoma, and gastric carcinoma-produce pth [10][11][12][13][14][15][16] , no available evidence indicates that oscc produces pth. The observed increase in pth in our patients is unlikely to be primary, considering that we observed no increase in serum calcium.…”

Section: Discussionmentioning

confidence: 99%

In Serum, Higher Parathyroid Hormone but Not Lower Vitamin D Is Associated with Oral Squamous Cell Carcinoma

Zhang

Shrestha

et al. 2015

Current Oncology

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Humoral hypercalcemia associated with gastric carcinoma secreting parathyroid hormone: a case report and review of the literature

Cited by 43 publications

References 22 publications

Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer

Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer

Synthetic biology-based cellular biomedical tattoo for detection of hypercalcemia associated with cancer

In Serum, Higher Parathyroid Hormone but Not Lower Vitamin D Is Associated with Oral Squamous Cell Carcinoma

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