In Serum, Higher Parathyroid Hormone but Not Lower Vitamin D Is Associated with Oral Squamous Cell Carcinoma

Zhang, H.; Lu, Hongbin; Shrestha, Chandrama; Feng, Yun‐Zhi; Li, Y.; Peng, Jinwu; Xie, Zhongjian

doi:10.3747/co.22.2259

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…Levels of osteocalcin, iPTH, bone formation markers including N-terminal propeptide of type I procollagen (P1NP) and bone resorption markers β C-terminal telopeptide of type Ⅰ collagen (β-CTX) were measured by electrochemiluminescence in the Clinical Laboratory of Endocrinology at the Second Xiangya Hospital of Central South University (Changsha, Hunan, China) to evaluate effects of a single dose of IM D2 on bone turnover (26,27). The interassay CV of the assay was 20%.…”

Section: Biochemical Marker Measurementsmentioning

confidence: 99%

Long-Term Bioavailability of Single Doses of Intramuscular Vitamin D2

Dai

Sun

et al. 2020

Endocrine Practice

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Section: Biochemical Marker Measurementsmentioning

confidence: 99%

Long-Term Bioavailability of Single Doses of Intramuscular Vitamin D2

Dai

Sun

et al. 2020

Endocrine Practice

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“…Four studies were conducted in Asia ( 11 , 12 , 14 , 17 ), 4 in Europe ( 10 , 13 , 15 , 18 ), 4 in North America (United States) ( 16 , 19 - 21 ), Six were case-control studies ( 11 - 13 , 15 - 17 ), 3 were cohort ( 10 , 14 , 18 ), and 3 were clinical trials ( 19 - 21 ). The methods of measuring serum vitamin D levels included electrochemiluminescence (n = 1) ( 12 ), chemiluminescence (n = 2) ( 13 , 14 ), enzyme-linked immunosorbent assays (n = 1) ( 17 ), liquid chromatography (n = 2) ( 10 , 18 ), and radioimmunoassay (n = 1) ( 17 ). Of the articles that specified the age of the patients ( 10 , 16 - 18 , 20 , 21 ), the age range was between 20 and 92 years, whereas that for patients with OPMDs was between 37.2 and 60.7 years.…”

Section: Resultsmentioning

confidence: 99%

“…Of the articles that specified the lesion site (n = 6) ( 11 , 13 - 15 , 18 , 20 ), for OSCC, the most frequent sites were the floor of the mouth, jugal mucosa, ridge, and tongue. Regarding the habits of the patients, 4 articles listed smoking ( 10 , 17 , 18 , 21 ), and of these, 3 also listed alcohol consumption ( 10 , 17 , 21 ). Three articles associated these habits with serum vitamin D levels ( 10 , 18 , 21 ), and 1 identified difference in smokers with low vitamin D levels ( 18 ).…”

Section: Resultsmentioning

confidence: 99%

“…Of the articles that considered patients with OSCC (n = 11) ( 10 , 11 , 13 , 14 , 21 ), 5 exclusively considered patients with OSCC ( 11 , 14 , 15 - 17 ), whereas 6 also included other locals of squamous cell carcinoma (SCC) such as oropharynx, nasopharynx, hypopharynx, and larynx ( 10 , 13 , 18 - 21 ). The results of the 5 articles that specified the measurement methods and values used for vitamin D are summarized in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

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Hypovitaminosis D, oral potentially malignant disorders, and oral squamous cell carcinoma: a systematic review

Maturana-Ramírez¹,

Saavedra²,

Guevara-Benítez³

et al. 2022

Med Oral

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Background Oral squamous cell carcinoma (OSCC) and potentially malignant oral disorders (OPMDs) could be associated with low levels of vitamin D. This systematic review aimed to determine the relationship between serum levels of vitamin D with OPMDs and OSCC. Material and Methods This review was conducted according to Cochrane guidelines (PROSPERO CRD42020207382) on literature retrieved from the PubMed, Cochrane, and Web of Science databases. The antecedents extracted were study design, methodology, sample (country, number of patients, age, and sex), oral manifestations (type of lesion, location, prevalence, and follow-up), serum vitamin D levels or use of vitamin D supplements, results, and conclusions. Results Twelve articles were selected. Some of the most relevant findings were alterations in vitamin D could favor the progress of OPMDs to OSCC. Higher levels of vitamin D can increase levels of anti-inflammatory mediators, CD4+ T lymphocytes and CD8+ T lymphocytes and CD3+ T lymphocytes in intratumoral tissue. The normalization of vitamin D levels in patients with OSCC can increased cytotoxic activity of natural killer cells, favoring antitumor immune response. Vitamin D supplemented can lower adverse effects associated with chemotherapy like mucositis and pain. Tobacco can increase risk of developing OSCC altering vitamin D levels. Conclusions Hypovitaminosis D could increase risk of developing OSCC from OPMDs, thus altering the immune response and it is associated with a lower survival rate in patients with OSCC, a greater recurrence of tumors in patients who underwent surgical treatment, and an increase in adverse reactions to chemotherapy. The use of vitamin D supplements can be a complement to primary therapy to prevent the recurrence of lesions and reduce adverse events associated with treatment. Key words: Oral squamous cell carcinoma (OSCC), Oral potentially malignant disorders (OPMDs), Vitamin D, Oral cancer.

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“…Vitamin D and calcium are known to regulate differentiation and proliferation of keratinocytes; they may potentially have roles in suppressing carcinogenesis in squamous epithelium 38 . Indeed, the importance of the vitamin D receptor (VDR) in regulating cellular proliferation and differentiation was verified when the skin of mice lacking the VDR was reported to be susceptible to tumour formation 38 . In addition, knockout of the calcium sensing receptor in addition to VDR accelerated the development of skin tumours 39 .…”

Section: Discussionmentioning

confidence: 99%

The parathyroid hormone regulates skin tumour susceptibility in mice

Okumura

Saito

Yoshizawa

et al. 2017

Sci Rep

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Using a forward genetics approach to map loci in a mouse skin cancer model, we previously identified a genetic locus, Skin tumour modifier of MSM 1 (Stmm1) on chromosome 7, conferring strong tumour resistance. Sub-congenic mapping localized Parathyroid hormone (Pth) in Stmm1b. Here, we report that serum intact-PTH (iPTH) and a genetic polymorphism in Pth are important for skin tumour resistance. We identified higher iPTH levels in sera from cancer-resistant MSM/Ms mice compared with susceptible FVB/NJ mice. Therefore, we performed skin carcinogenesis experiments with MSM-BAC transgenic mice (Pth MSM-Tg) and Pth knockout heterozygous mice (Pth +/−). As a result, the higher amounts of iPTH in sera conferred stronger resistance to skin tumours. Furthermore, we found that the coding SNP (rs51104087, Val28Met) localizes in the mouse Pro-PTH encoding region, which is linked to processing efficacy and increased PTH secretion. Finally, we report that PTH increases intracellular calcium in keratinocytes and promotes their terminal differentiation. Taken together, our data suggest that Pth is one of the genes responsible for Stmm1, and serum iPTH could serve as a prevention marker of skin cancer and a target for new therapies.

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In Serum, Higher Parathyroid Hormone but Not Lower Vitamin D Is Associated with Oral Squamous Cell Carcinoma

Abstract: Introduction Vitamin D and calcium are known to regulate differentiation and proliferation of keratinocytes;

Cited by 8 publications

References 29 publications

Long-Term Bioavailability of Single Doses of Intramuscular Vitamin D2

Long-Term Bioavailability of Single Doses of Intramuscular Vitamin D2

Hypovitaminosis D, oral potentially malignant disorders, and oral squamous cell carcinoma: a systematic review

The parathyroid hormone regulates skin tumour susceptibility in mice

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