Human vital amniotic membrane reduces adhesions in experimental intraperitoneal onlay mesh repair

Petter-Puchner, Alexander H.; Fortelny, René H.; Mika, K.; Hennerbichler, Simone; Redl, Heinz; Gabriel, Christian

doi:10.1007/s00464-010-1507-y

Cited by 22 publications

(15 citation statements)

References 31 publications

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“…Placentas and fetal membranes have been successfully used for tissue engineering applications. For instance, amniotic membrane has been used to prevent adhesions [Kuriu et al, 2009;Petter-Puchner et al, 2011;Ellington and Ferguson, 2014], to repair recto-vaginal fistulas [Roshanravan et al, 2014], to treat skin burns and wounds [Taghiabadi et al, 2015] and chronic leg ulcers [Zelen et al, 2013], and for regeneration of corneal and conjunctival epithelium [Yokogawa et al, 2014;Zeng et al, 2014;Zhou et al, 2015], although it was ineffective for treatment of Mooren's ulcer, a rare but severe ulcerative keratitis [Schallenberg et al, 2013]. In addition, its anticancer properties have been noted, probably due to the downregulation of HSP90 (heat shock protein 90), cancer cell cycle arrest and inhibition of angiogenesis [Magatti et al, 2012;Niknejad and Yazdanpanah, 2014].…”

Section: Placental Ecm and Its Tissue Engineering Applicationsmentioning

confidence: 99%

The Placenta as an Organ and a Source of Stem Cells and Extracellular Matrix: A Review

Lobo¹,

Leonel²,

Miranda³

et al. 2016

Cells Tissues Organs

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The placenta is a temporal, dynamic and diverse organ with important immunological features that facilitate embryonic and fetal development and survival, notwithstanding the fact that several aspects of its formation and function closely resemble tumor progression. Placentation in mammals is commonly used to characterize the evolution of species, including insights into human evolution. Although most placentas are discarded after birth, they are a high-yield source for the isolation of stem/progenitor cells and are rich in extracellular matrix (ECM), representing an important resource for regenerative medicine purposes. Interactions among cells, ECM and bioactive molecules regulate tissue and organ generation and comprise the foundation of tissue engineering. In the present article, differences among several mammalian species regarding the placental types and classifications, phenotypes and potency of placenta-derived stem/progenitor cells, placental ECM components and current placental ECM applications were reviewed to highlight their potential clinical and biomedical relevance.

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Section: Placental Ecm and Its Tissue Engineering Applicationsmentioning

confidence: 99%

The Placenta as an Organ and a Source of Stem Cells and Extracellular Matrix: A Review

Lobo¹,

Leonel²,

Miranda³

et al. 2016

Cells Tissues Organs

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“…It is also possible to use amnion to treat adhesion‐related pathologies. It was proven that it reduced adhesions, inflammation and fibrosis in experimental, animal models …”

Section: New and Unusual Applications Of Amniotic Membrane In The Woumentioning

confidence: 99%

“…It was proven that it reduced adhesions, inflammation and fibrosis in experimental, animal models. 105,106 Amniotic membrane has also a potential to be used in orthopaedic, urological and periapical surgery. It was successfully implanted together with a tendon graft during anterior cruciate ligament (ACL) reconstruction, which reduced pain and decreased complication rates.…”

Section: New and Unusual Applications Of Amniotic Membrane In The Wmentioning

confidence: 99%

Preparation of placental tissue transplants and their application in skin wound healing and chosen skin bullous diseases ‐ Stevens‐Johnson syndrome and toxic epidermal necrolysis treatment

Klama-Baryła¹,

Rojczyk

Kitala³

et al. 2020

International Wound Journal

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Unique properties of amniotic membrane make it a promising source for tissue engineering and a clinically useful alternative for patients suffering from chronic wounds including, for example, ulcers, burns, ocular surface damages and wounds occurring in the course of bullous diseases like stevens‐johnson syndrome and toxic epidermal necrolysis. Its use has many advantages over standard wound care, as it contains pluripotent cells, nutrients, anti‐fibrotic and anti‐inflammatory cytokines, growth factors and extracellular matrix (ECM) proteins. Placental tissues can be prepared as a medical component, an advanced therapy medicinal product or a tissue graft. In addition to basic preparation procedures such as washing, rinsing, cutting, drying and sterilisation, there are many optional steps such as perforation, crosslinking and decellularisation. Finally, transplants should be properly stored—in cryopreserved or dehydrated form. In recent years, many studies including basic science and clinical trials have proven the potential to expand the use of amniotic membrane and amnion‐derived cells to the fields of orthopaedics, dentistry, surgery, urology, vascular tissue engineering and even oncology. In this review, we discuss the role of placental tissues in skin wound healing and in the treatment of various diseases, with particular emphasis on bullous diseases. We also describe some patented procedures for placental tissue grafts preparation.

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“…However, due to its high cost and some reported adverse effects post‐implantation (abscess, intense inflammatory reaction and sepsis) other anti‐adhesive systems are being developed. For instance, anti‐adherent layers made of biologic active membranes have been combined with meshes (i.e., human amniotic membrane containing resilient pluripotent epithelial and mesenchymal stem cells), but contradicting results were seen, depending on the membrane preparation and sterilization process…”

Section: Anti‐adhesive Meshmentioning

confidence: 99%

Emerging Trends in Abdominal Wall Reinforcement: Bringing Bio‐Functionality to Meshes

Guillaume

Teuschl

Gruber-Blum

et al. 2015

Adv Healthcare Materials

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Abdominal wall hernia is a recurrent issue world-wide and requires the implantation of over 1 million meshes per year. Because permanent meshes such as polypropylene and polyester are not free of complications after implantation, many mesh modifications and new functionalities have been investigated over the last decade. Indeed, mesh optimization is the focus of intense development and the biomaterials utilized are now envisioned as being bioactive substrates that trigger various physiological processes in order to prevent complications and to promote tissue integration. In this context, it is of paramount interest to review the most relevant bio-functionalities being brought to new meshes and to open new avenues for the innovative development of the next generation of meshes with enhanced properties for functional abdominal wall hernia repair.

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Human vital amniotic membrane reduces adhesions in experimental intraperitoneal onlay mesh repair

Abstract: Human vital AM was highly effective in reducing adhesions to polypropylene mesh and sutures in experimental IPOM. No adverse effects were detected, and tissue integration of the mesh was good.

Cited by 22 publications

References 31 publications

The Placenta as an Organ and a Source of Stem Cells and Extracellular Matrix: A Review

The Placenta as an Organ and a Source of Stem Cells and Extracellular Matrix: A Review

Preparation of placental tissue transplants and their application in skin wound healing and chosen skin bullous diseases ‐ Stevens‐Johnson syndrome and toxic epidermal necrolysis treatment

Emerging Trends in Abdominal Wall Reinforcement: Bringing Bio‐Functionality to Meshes

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