Human umbilical cord mesenchymal stem cell-derived exosomes act via the miR-1263/Mob1/Hippo signaling pathway to prevent apoptosis in disuse osteoporosis

Yang, Biao; Kuang, Ming-jie; Kang, Jia-yu; Zhao, Jie; Ma, Jianxiong; Ma, Xinlong

doi:10.1016/j.bbrc.2020.02.001

Cited by 68 publications

(75 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…84 Exosomes from the BMSCs of osteoporosis patients decrease the osteogenic ability of MSCs by targeting the microRNA-21/SMAD7 pathway. 85 Exosomes from different tissue-derived MSCs or iPS cell-derived MSCs could prevent bone loss, promote bone formation, and prevent osteoporosis in experimental animal models, [86][87][88][89] indicating that MSC-derived exosomes could be a potential therapeutic treatment for osteoporosis. 90 In addition to osteoporosis, MSC-derived exosomes also greatly contribute to fracture healing.…”

Section: Exosomementioning

confidence: 99%

Exosomes: roles and therapeutic potential in osteoarthritis

Ni¹,

et al. 2020

View full text Add to dashboard Cite

Exosomes participate in many physiological and pathological processes by regulating cell-cell communication, which are involved in numerous diseases, including osteoarthritis (OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling. This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future.

show abstract

Section: Exosomementioning

confidence: 99%

Exosomes: roles and therapeutic potential in osteoarthritis

Ni¹,

et al. 2020

View full text Add to dashboard Cite

show abstract

“…to play a role in the treatment of OP. In the rat model of disuse osteoporosis (DOP), exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSC-Exos) can reduce the apoptosis of MSCs in DOP rats through the miR-1263/Mob1/Hippo signaling pathway ( Yang et al, 2020 ). The specific mechanism involves the miR-1263-mediated inhibition of Mob1 expression, which activates YAP1 and inhibits apoptosis.…”

Section: Role Of Yap1 In Opmentioning

confidence: 99%

“…However, none of these YAP1 agonists have been studied in OP, and their efficacy against OP remains unknown. In addition to YAP1 agonists, YAP1 can also mediate the therapeutic effects of the genes or proteins mentioned above in OP ( Bian et al, 2016 ; Li et al, 2019 ; Wang et al, 2019 ; Lin et al, 2020 ; Yang et al, 2020 ).…”

Section: Role Of Yap1 In Opmentioning

confidence: 99%

Yes-Associated Protein 1: Role and Treatment Prospects in Orthopedic Degenerative Diseases

Xie

Xiao

Tang

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

The Hippo/yes-associated protein 1 signaling pathway is an evolutionarily conserved signaling pathway. This signaling pathway is primarily involved in the regulation of stem cell self-renewal, organ size and tissue regeneration by regulating cell proliferation, differentiation and apoptosis. It plays an important role in embryonic development and tissue organ formation. Yes-associated protein 1 (YAP1) is a key transcription factor in the Hippo signaling pathway and is negatively regulated by this pathway. Changes in YAP1 expression levels affect the occurrence and development of a variety of tumors, but the specific mechanism associated with this phenomenon has not been thoroughly studied. Recently, several studies have described the role of YAP1 in osteoarthritis (OA). Indeed, YAP1 is involved in orthopedic degenerative diseases such as osteoporosis (OP) in addition to OA. In this review, we will summarize the significance of YAP1 in orthopedic degenerative diseases and discuss the potential of the targeted modulation of YAP1 for the treatment of these diseases.

show abstract

“…Increasingly, MSC exosomes have replicated the wide-ranging therapeutic efficacies of MSCs in several injury and disease indications such as myocardial ischemia reperfusion injury [ 29 ], drug-induced liver injury [ 30 ], retinal laser injury [ 31 ], pulmonary hypertension [ 32 ], and graft-versus-host-disease [ 33 , 34 ]. MSC exosomes were also reported to be efficacious in enhancing skeletal muscle regeneration [ 35 , 36 ] and more recently cartilage [ 23 , [37] , [38] , [39] , [40] ] and bone regeneration [ [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] ].…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cell exosomes in bone regenerative strategies—a systematic review of preclinical studies

Tan

Wong

Sim

et al. 2020

Materials Today Bio

View full text Add to dashboard Cite

The ability of bone for regeneration has long been recognized. However, once beyond a critical size, spontaneous regeneration of bone is limited. Several studies have focused on enhancing bone regeneration by applying mesenchymal stromal/stem cells (MSCs) in the treatment strategies. Despite the therapeutic efficacy of MSCs in bone regeneration, cell-based therapies are impeded by several challenges in maintaining the optimal cell potency and viability during expansion, storage, and final delivery to patients. Recently, there has been a paradigm shift in therapeutic mechanism of MSCs in tissue repair from one based on cellular differentiation and replacement to one based on secretion and paracrine signaling. Among the broad spectrum of trophic factors, extracellular vesicles particularly the exosomes have been reported to be therapeutically efficacious in several injury/disease indications, including bone defects and diseases. The current systematic review aims to summarize the results of the existing animal studies which were conducted to evaluate the therapeutic efficacy of MSC exosomes for bone regeneration. Following the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines, the PubMed and The Cochrane Library database were searched for relevant controlled preclinical animal studies. A total of 23 studies were identified, with the total sample size being 690 rats or mice and 38 rabbits. Generally, MSC exosomes were found to be efficacious for bone regeneration in animal models of bone defects and diseases such as osteonecrosis and osteoporosis. In these studies, MSC exosomes promoted new bone formation with supporting vasculature and displayed improved morphological, biomechanical, and histological outcomes, coupled with positive effects on cell survival, proliferation, and migration, osteogenesis, and angiogenesis. Unclear-to-low risk in bias and incomplete reporting in the primary studies highlighted the need for standardization in outcome measurements and reporting. Further studies in large animal models to establish the safety and efficacy would provide useful information on guiding the design of clinical trials.

show abstract

Human umbilical cord mesenchymal stem cell-derived exosomes act via the miR-1263/Mob1/Hippo signaling pathway to prevent apoptosis in disuse osteoporosis

Cited by 68 publications

References 23 publications

Exosomes: roles and therapeutic potential in osteoarthritis

Exosomes: roles and therapeutic potential in osteoarthritis

Yes-Associated Protein 1: Role and Treatment Prospects in Orthopedic Degenerative Diseases

Mesenchymal stem cell exosomes in bone regenerative strategies—a systematic review of preclinical studies

Contact Info

Product

Resources

About