Human umbilical cord mesenchymal stem cell-derived exosomes loaded miR-451a targets ATF2 to improve rheumatoid arthritis

Mi, Liangyu; Gao, Jinfang; Li, Na; Liu, Ying; Zhang, Na; Gao, Yanan; Peng, Xinyue; Zhang, Liyun; Xu, Ke

doi:10.1016/j.intimp.2023.111365

Cited by 8 publications

(5 citation statements)

References 51 publications

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“…Importantly, these exosomes inhibited pro flammatory responses in RA-FLSs by decreasing the secretion of interleukin-1β (IL and TNF-α [42]. MiR-451a is another RNA molecule secreted by UC-MSCs that has b suggested to decrease the invasiveness of RA-FLSs [41]. Importantly, the treatmen MSCs with various factors can modulate their activity or immunomodulatory propert Chiu and colleagues showed that tumour necrosis factor-related apoptosis-inducing and (TRAIL) is upregulated in UC-MSCs after stimulation with IL-1β.…”

Section: Mesenchymal Stromal Cells and Rheumatoid Arthritis Fibroblas...mentioning

confidence: 99%

“…[50] MSC-derived exosomes containing miR-451a Exosomes overexpressing miR-451a suppressed RA-FLS migration, proliferation, and invasion. [41] MSC-derived exosomes containing HAND2-AS1…”

Section: Uc-mscsmentioning

confidence: 99%

“…Mi et al found that stimulating RA-FLSs with exosomes obtained from UC-MSCs significantly alters the expression of 13 miRNAs. Importantly, these structures could suppress the proliferation of RA-FLSs [ 41 ]. Huang and collaborators demonstrated that the co-culture of RA-FLSs with exosomes obtained from UC-MSCs could increase the expression of miR-140-3p in the former cells.…”

Section: Mesenchymal Stromal Cells and Rheumatoid Arthritis Fibroblas...mentioning

confidence: 99%

“…Thus, these exosomes could suppress cartilage degeneration and angiogenesis, important processes in RA progression [ 49 ]. Similarly, exosomes containing miR-124a and miR-451a also reduced the invasiveness of RA-FLSs [ 41 , 50 ]. Another molecule that suppresses the invasive features of RA-FLSs is lncRNA heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1).…”

Section: Mesenchymal Stromal Cells and Rheumatoid Arthritis Fibroblas...mentioning

confidence: 99%

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The Role of Mesenchymal Stromal Cells in the Treatment of Rheumatoid Arthritis

Bakinowska,

Bratborska,

Kiełbowski

et al. 2024

Cells

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Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterised by the formation of a hyperplastic pannus, as well as cartilage and bone damage. The pathogenesis of RA is complex and involves broad interactions between various cells present in the inflamed synovium, including fibroblast-like synoviocytes (FLSs), macrophages, and T cells, among others. Under inflammatory conditions, these cells are activated, further enhancing inflammatory responses and angiogenesis and promoting bone and cartilage degradation. Novel treatment methods for RA are greatly needed, and mesenchymal stromal cells (MSCs) have been suggested as a promising new regenerative and immunomodulatory treatment. In this paper, we present the interactions between MSCs and RA-FLSs, and macrophages and T cells, and summarise studies examining the use of MSCs in preclinical and clinical RA studies.

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Section: Mesenchymal Stromal Cells and Rheumatoid Arthritis Fibroblas...mentioning

confidence: 99%

“…[50] MSC-derived exosomes containing miR-451a Exosomes overexpressing miR-451a suppressed RA-FLS migration, proliferation, and invasion. [41] MSC-derived exosomes containing HAND2-AS1…”

Section: Uc-mscsmentioning

confidence: 99%

Section: Mesenchymal Stromal Cells and Rheumatoid Arthritis Fibroblas...mentioning

confidence: 99%

Section: Mesenchymal Stromal Cells and Rheumatoid Arthritis Fibroblas...mentioning

confidence: 99%

See 2 more Smart Citations

The Role of Mesenchymal Stromal Cells in the Treatment of Rheumatoid Arthritis

Bakinowska,

Bratborska,

Kiełbowski

et al. 2024

Cells

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“…Improvement in inflammation and disease manifestation was observed in mice. 9 Previous study of miRNA MSC-derived exosome content, specifically miR-150, identified that these exosomes were able to interfere with the FLSs aggressive phenotype, by targeting MMP14 and VEGF in mice. Reduced angiogenesis and hyperplasia in the synovium were noted as well.…”

Section: Therapeutic and Diagnostic Potential Of Evsmentioning

confidence: 99%

Updates on the Pathophysiology and Therapeutic Potential of Extracellular Vesicles with Focus on Exosomes in Rheumatoid Arthritis

Gavriilidi,

Wielińska,

Bogunia-Kubik

2024

JIR

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Rheumatoid arthritis (RA) is an incurable autoimmune disease with high morbidity and socioeconomic burden. Advances in therapeutics have improved patients’ quality of life, however due to the complex disease pathophysiology and heterogeneity, 30% of patients do not respond to treatment. Understanding how different genetic and environmental factors contribute to disease initiation and development as well as uncovering the interactions of immune components is key to the implementation of effective and safe therapies. Recently, the role of extracellular vesicles (EVs) in RA development and possible treatment has been an area of interest. EVs are small lipid-bound entities, often containing genetic material, proteins, lipids and amino acids, facilitating paracrine intercellular communication. They are secreted by all cells, and it is believed that they possess regulatory functions due to high complexity and functional diversity. Although it has been shown that EVs participate in RA pathophysiology, through immune modulation, their exact role remains elusive. Furthermore, EVs could be a promising therapeutic agent in various diseases including RA, due to their biocompatibility, low toxicity and possible manipulation, but further research is required in this area. This review provides a comprehensive discussion of disease pathophysiology and summarizes the latest knowledge regarding the role and therapeutic potential of EVs in RA.

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