Human Tissue Investigations Using PALS Technique - Free Radicals Influence

Jasińska, B.; Zgardzińska, B.; Chołubek, Gustaw; Pietrow, M.; Gorgol, M.; Wiktor, Krzysztof; Wysogląd, K.; Białas, P.; Curceanu, C.; Czerwiński, E.; Dulski, K.; Gajos, A.; Głowacz, B.; Hiesmayr, Beatrix C.; Jodłowska‐Jędrych, Barbara; Kamińska, D.; Korcyl, G.; Kozik, T.; Krawczyk, N.; Krzemień, W.; Kubicz, E.; Mohammed, M.; Pawlik-Niedźwiecka, M.; Niedźwiecki, Sz.; Pałka, M.; Raczyński, L.; Rudy, Z.; Sharma, N.G.; Sharma, Sushil; Shopa, R. Y.; Silarski, M.; Skurzok, M.; Wieczorek, A.; Wiktor, Henryk; Wiślicki, W.; Zieliński, Marcin; Moskal, P.

doi:10.12693/aphyspola.132.1556

Cited by 18 publications

(25 citation statements)

References 43 publications

(34 reference statements)

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“…In the body, the mean lifetime of ortho-positronium varies from approximately 1.8 ns in pure water to approximately 4 ns in human skin. 80 Moreover, both formation probability and mean lifetime depend on the concentration of the bio-fluids and bio-active molecules 81,82 and the mean lifetime can be established in the human body with the precision of approximately 20 ps. 29 There are investigations demonstrating differences between normal and cancerous cells with changes of the positronium lifetime during dynamic processes undergoing in model and living biological systems.…”

Section: Positronium Imagingmentioning

confidence: 99%

“…29 There are investigations demonstrating differences between normal and cancerous cells with changes of the positronium lifetime during dynamic processes undergoing in model and living biological systems. [79][80][81][85][86][87][88][89][90][91][92][93][94][95] Therefore, positronium may be used as a sensor of the surrounding tissue environment, and imaging of its properties inside the patient body may serve as additional diagnostic indicator. In general, positronium imaging can be defined as a method for the position-sensitive reconstruction of positronium properties (such as mean lifetime, formation probability, and 3g/2g rate ratio) within the imaged object.…”

Section: Positronium Imagingmentioning

confidence: 99%

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Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators

Moskal

Stępień

2020

PET Clinics

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Total-body PET opens a new diagnostic paradigm with prospects for personalized disease treatment, yet the high cost of the current crystal-based PET technology limits dissemination of totalbody PET in hospitals and even in the research clinics. The J-PET tomography system is based on axially arranged low-cost plastic scintillator strips. It constitutes a realistic cost-effective solution of a total-body PET for broad clinical applications. High sensitivity of total-body J-PET and triggerless data acquisition enable multiphoton imaging, opening possibilities for multitracer and positronium imaging, thus promising quantitative enhancement of specificity in cancer and inflammatory diseases assessment. An example of dual tracer analysis, becoming possible with total-body J-PET system, could be a concurrent application of Food and Drug Administration-approved 82 Rb-Chloride and [ 18 F]FDG, allowing simultaneous assessment of myocardium metabolic rate and perfusion of the cardiovascular system.

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Section: Positronium Imagingmentioning

confidence: 99%

Section: Positronium Imagingmentioning

confidence: 99%

Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators

Moskal

Stępień

2020

PET Clinics

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“…An important advantage of this choice is also the availability of the reference sample—as a result of the hysterectomy, the entire organ is removed, and therefore both the changed (leiomyomas) and healthy tissues are available. Pilot studies made using the PALS technique 20 , 21 have already shown that the interpretation of o-Ps parameters will be possible if the result obtained for diseased tissue can be related to the results obtained for healthy tissue. Therefore, the samples are taken in pairs: abnormal and normal (neoplastic and healthy).…”

Section: Introductionmentioning

confidence: 99%

Studies on healthy and neoplastic tissues using positron annihilation lifetime spectroscopy and focused histopathological imaging

Zgardzińska

Chołubek

Jarosz

et al. 2020

Sci Rep

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Samples of healthy and neoplastic myometrial tissues were investigated using Positron Annihilation Lifetime Spectroscopy (PALS). Meaningful differences between normal and diseased tissues were observed for each patient. The differences were also clearly visible for various kinds of lesions in each patient. The set of lifetimes and intensities obtained from PALS was correlated with the histopathological examinations of the same fragments of tissues. Strong coincidence between PALS parameters and histopathological findings was observed only in the case of a very precise correlation of the investigated area in both techniques. Measurements and discussion presented here were carried out to develop a method for measuring the sub-nanometric structure of human tissues. This kind of investigation, using positron probe, creates an opportunity of a new application in Positron Emission Tomography (PET).

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“…That is why they are radioresistant. Nevertheless, this effect is important when testing healthy and cancerous tissues of living organisms by the methods of positron annihilation spectroscopy [4].…”

Section: Introductionmentioning

confidence: 99%

Dissolved oxygen and positronium atom in liquid media

Степанов¹,

Bokov²,

Ilyukhina³

et al. 2020

RENSIT

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The interaction of positronium (Ps) with molecular oxygen dissolved in liquids (isooctane, cyclohexane, isopropanol and water) is experimentally investigated. For variation of the O 2 concentration the liquids were bubbled with Ar, air and O 2. For interpretation of the lifetime annihilation spectra a simple deconvolution of the spectra into three exponentials decaying in time was used. These exponents correspond to para-positronium, free positron and ortho-positronium annihilations. The total reaction rate constant of the Ps atom with dissolved oxygen (which is the sum of two-ortho-para-conversion (Ps → ¼ p-Ps + ¾ o-Ps) and oxidation (Ps + O 2 → e + + O 2-) reaction rate constants) is obtained for each liquid.

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Human Tissue Investigations Using PALS Technique - Free Radicals Influence

Cited by 18 publications

References 43 publications

Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators

Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators

Studies on healthy and neoplastic tissues using positron annihilation lifetime spectroscopy and focused histopathological imaging

Dissolved oxygen and positronium atom in liquid media

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