Human T‐cell lymphotropic virus type‐1 infection and risk of cancer: 15.4 year longitudinal study among atomic bomb survivors in Nagasaki, Japan

Arisawa, Kokichi; Soda, Midori; Akahoshi, Masazumi; Fujiwara, Saeko; Uemura, Hirokazu; Hiyoshi, Mineyoshi; Takeda, H.; Kashino, Wataru; Suyama, Akihiko

doi:10.1111/j.1349-7006.2006.00212.x

Cited by 24 publications

(17 citation statements)

References 30 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…to estimate the incidence of breast cancer among HTLV-1 infected population of old women with habits of prolonged breast-feeding. In the second publication [53] the authors examined the development of different kinds of cancers, including breast cancer, in HTLV-1 infected Japanese population. However, these authors did not focus on old women with habits of prolonged breast-feeding.…”

Section: Discussionmentioning

confidence: 99%

HTLV-1 Tax Oncoprotein Inhibits the Estrogen-Induced-ER α-Mediated BRCA1 Expression by Interaction with CBP/p300 Cofactors

et al. 2014

View full text Add to dashboard Cite

BRCA1 is a multifunctional tumor suppressor, whose expression is activated by the estrogen (E2)-liganded ERα receptor and regulated by certain recruited transcriptional co-activators. Interference with BRCA1 expression and/or functions leads to high risk of breast or/and ovarian cancer. Another multifunctional protein, HTLV-1Tax oncoprotein, is widely regarded as crucial for developing adult T-cell leukemia and other clinical disorders. Tax profile reveals that it can antagonize BRCA1 expression and/or functionality. Therefore, we hypothesize that Tax expression in breast cells can sensitize them to malignant transformation by environmental carcinogens. Here we examined Tax effect on BRCA1 expression by testing its influence on E2-induced expression of BRCA1 promoter-driven luciferase reporter (BRCA1-Luc). We found that E2 strongly stimulated this reporter expression by liganding to ERα, which consequently associated with BRCA1 promoter, while ERα concomitantly recruited CBP/p300 to this complex for co-operative enhancement of BRCA1 expression. Introducing Tax into these cells strongly blocked this E2-ERα-mediated activation of BRCA1 expression. We noted, also, that Tax exerted this inhibition by binding to CBP/p300 without releasing them from their complex with ERα. Chip assay revealed that the binding of Tax to the CBP/p300-ERα complex, prevented its link to AP1 site. Interestingly, we noted that elevating the intracellular pool of CBP or p300 to excessive levels dramatically reduced the Tax-mediated inhibition of BRCA1 expression. Exploring the mechanism of this reduction revealed that the excessive co-factors were sufficient to bind separately the free Tax molecules, thus lowering their amount in the CBP/p300-ERα complex and relieving, thereby, the inhibition of BRCA1 expression.

show abstract

Section: Discussionmentioning

confidence: 99%

HTLV-1 Tax Oncoprotein Inhibits the Estrogen-Induced-ER α-Mediated BRCA1 Expression by Interaction with CBP/p300 Cofactors

et al. 2014

View full text Add to dashboard Cite

show abstract

“…HTLV-1 is a retrovirus that causes ATL, an aggressive form of T-cell malignancy (Arisawa et al, 2006). HTLV-1 is transmitted from mother to infant via breast milk and is known to be prevalent in several specific areas in the world, including Southwestern Japan (Arisawa et al, 2006). It was estimated that there were 10-20 millions HTLV-1 infected individuals in the world (de The and Bomford, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes an aggressive form of T-cell malignancy called adult T-cell leukemia/lymphoma (ATL) (Arisawa et al, 2006). The association between HTLV-1 infection and cancer occurrence is controversial.…”

Section: Introductionmentioning

confidence: 99%

“…The association between HTLV-1 infection and cancer occurrence is controversial. HTLV-1-infected patients are reported to be at significantly high risk of developing liver cancer and lymphomas other than ATL (Arisawa et al, 2006;Tanaka et al, 2016). However, a lower incidence of HTLV-1 in gastric cancer patients compared to the general population suggests that HTLV-1 infection reduces the risk of gastric cancer (Hirata et al, 2007;Matsumoto et al, 2008;Tahaei et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Features of Breast Cancer Patients with Human T-Cell Lymphotropic Virus Type-1 Infection

Hirata

Shinden

Nagata

et al. 2019

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Background:Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes adult T-cell leukemia/lymphoma (ATL), an aggressive form of T-cell malignancy. The relationship between HTLV-1 infection and cancer progression is controversial. HTLV-1 encodes oncogenic protein TAX1 and it is hypothesized that HTLV-1 infection is associated with breast cancer progression. In this study, we evaluated the relationship between HTLV-1 infection and clinicopathological factors in breast cancer patients. Methods: We retrospectively analyzed 610 patients with primary breast cancer who underwent surgical treatment without preoperative chemotherapy at Kagoshima University Hospital between January 2001 and January 2015. Results: When patients with and without HTLV-1 infection were compared, no differences in clinicopathological factors were observed, except for age. Disease-free survival and overall survival rates did not differ between groups. Conclusions: HTLV-1-positive patients were significantly older than HTLV-1-negative patients. It was supposed to be due to the fact that the HTLV-1 infection rate is decreasing. Any effect of HTLV-1 infection on breast cancer progression appears to be negligibly small.we evaluated the relationship between HTLV-1 infection and clinicopathological factors in breast cancer patients.

show abstract

“…22,26 So, it is worthwhile to study possible benefits of TPA treatment as preventive against ovarian or mammary tumors development. However, on the other hand TPA strongly stimulated the expression of genes controlled by ERE sequences which part of them are responsible for enhanced replication of the cells 65 and as consequences of that these cells may acquire high excess of mutations which might lead to tumors development. These results are in agreement with previous studies which showed that treatment with TPA increased pS2 mRNA expression more dramatically than the stimulation by E2.…”

Section: Discussionmentioning

confidence: 99%

Effect of TPA and HTLV-1 Tax on BRCA1 and ERE controlled genes expression

et al. 2017

View full text Add to dashboard Cite

Interference with the expression and/or functions of the multifunctional tumor suppressor BRCA1 leads to a high risk of breast and ovarian cancers. BRCA1 expression is usually activated by the estrogen (E2) liganded ERα receptor. Activated ERα is considered as a potent transcription factor which activates various genes expression by 2 pathways. A classical pathway, ERα binds directly to E2-responsive elements (EREs) in the promoters of the responsive genes and a non-classical pathway where ERα indirectly binds with the appropriate gene promoter. In our previous study, HTLV-1Tax was found to strongly inhibit ERα induced BRCA1 expression while stimulating ERα induced ERE dependent genes. TPA is a strong PKC activator which found to induce the expression of HTLV-1. Here we examined the effect of TPA on the expression of BRCA1 and genes controlled by ERE region in MCF-7 cells and on Tax activity on these genes. Our results showed strong stimulatory effect of TPA on both BRCA1 and ERE expression without treatment with E2. Tax did not show any significant effect on these TPA activities. It seems that TPA activation of BRCA1 and ERE expression is dependent on PKC activity but not through the NFκB pathway. However, 53BP1 may be involved in this TPA activity because its overexpression significantly reduced the TPA stimulatory effect on BRCA1 and ERE expression. Additionally, our Chip assay results probably exclude possible involvement of ERα pathway in this TPA activity because TPA did not interfere with the binding of ERα to both BRCA1 promoter and ERE region.

show abstract

Human T‐cell lymphotropic virus type‐1 infection and risk of cancer: 15.4 year longitudinal study among atomic bomb survivors in Nagasaki, Japan

Cited by 24 publications

References 30 publications

HTLV-1 Tax Oncoprotein Inhibits the Estrogen-Induced-ER α-Mediated BRCA1 Expression by Interaction with CBP/p300 Cofactors

HTLV-1 Tax Oncoprotein Inhibits the Estrogen-Induced-ER α-Mediated BRCA1 Expression by Interaction with CBP/p300 Cofactors

Clinical Features of Breast Cancer Patients with Human T-Cell Lymphotropic Virus Type-1 Infection

Effect of TPA and HTLV-1 Tax on BRCA1 and ERE controlled genes expression

Contact Info

Product

Resources

About