Clinical Features of Breast Cancer Patients with Human T-Cell Lymphotropic Virus Type-1 Infection

Hirata, Munetsugu; Shinden, Yoshiaki; Nagata, Ayako; Nomoto, Yukio; Saho, Hazuki; Nakajo, Akihiro; Arigami, Takaaki; Kurahara, Hiroshi; Maemura, Kosei; Kijima, Yuko

doi:10.31557/apjcp.2019.20.6.1909

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…A recent case report by Dahy et al reported a newly diagnosed small-cell lung cancer patient with a history of HTLV-1-associated myelopathy (6). Hirata et al evaluated the clinicopathologic features of HTLV-1-positive patients with breast cancer and found that these patients were older; however, their survival was unrelated to the virus infection (7). Other studies in this context are case reports on the association of HTLV-1 with other carcinomas, and there are no considerable studies in this context.…”

Section: Discussionmentioning

confidence: 99%

Association Between HTLV-1 Infection and Nasopharyngeal Carcinoma: A Case-Control Study

Kalantari

Majidi

et al. 2023

Rep Radiother Oncol

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Background: The northeast of Iran is one of the endemic regions of human T-cell lymphotropic virus type-1 (HTLV-1). This study aimed to evaluate the relationship between nasopharyngeal carcinoma and HTLV-1 infection in northeast Iran, an endemic area for HTLV-1. Methods: In this case-control study, paraffin-embedded nasopharyngeal tissue samples of patients with definitive nasopharyngeal carcinoma were evaluated for the presence of the HTLV-1 genome by polymerase chain reaction retrospectively. Results: Thirty patients with nasopharyngeal carcinoma and 30 healthy people were evaluated. All participants were matched in terms of age and gender, and all were living in Mashhad. The HTLV-1 genome was detected in only one of the people in the healthy group. Conclusions: The HTLV-1 infection and nasopharyngeal carcinoma did not correlate significantly.

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Section: Discussionmentioning

confidence: 99%

Association Between HTLV-1 Infection and Nasopharyngeal Carcinoma: A Case-Control Study

Kalantari

Majidi

et al. 2023

Rep Radiother Oncol

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“…The virus has known oncogenic potential in specific cancers, including the cervix, liver, head and neck, some lymphomas, and breast cancer 65 . HTLV-1 is one of the viruses that encode oncogenic protein Tax1 Binding Protein 1 (TAX1) and help breast cancer progression 66 . TAX1 protein can inactivate the function of cellular TP53 and postpone the G1 cell cycle arrest required for repairing DNA in response to DNA damage 67 .…”

Section: Discussionmentioning

confidence: 99%

A Motif-Based Network Analysis of Regulatory Patterns in Doxorubicin Effects on Treating Breast Cancer, a Systems Biology Study

Dehghan¹,

Mirmotalebisohi²,

Sameni³

et al. 2022

AJMB

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Background: Breast cancer is the most common malignancy worldwide. Doxorubicin is an anthracycline used to treat breast cancer as the first treatment choice. Nevertheless, the molecular mechanisms underlying the response to Doxorubicin and its side effects are not comprehensively understood so far. We used systems biology and bioinformatics methods to identify essential genes and molecular mechanisms behind the body response to Doxorubicin and its side effects in breast cancer patients. Methods: Omics data were extracted and analyzed to construct the protein-protein interaction and gene regulatory networks. Network analysis was performed to identify hubs, bottlenecks, clusters, and regulatory motifs to evaluate crucial genes and molecular mechanisms behind the body response to Doxorubicin and its side effects. Results: Analyzing the constructed PPI and gene-TF-miRNA regulatory network showed that MCM3, MCM10, and TP53 are key hub-bottlenecks and seed proteins. Enrichment analysis also revealed cell cycle, TP53 signaling, Forkhead box O (FoxO) signaling, and viral carcinogenesis as essential pathways in response to this drug. Besides, SNARE interactions in vesicular transport and neurotrophin signaling were identified as pathways related to the side effects of Doxorubicin. The apoptosis induction, DNA repair, invasion inhibition, metastasis, and DNA replication are suggested as critical molecular mechanisms underlying Doxorubicin anti-cancer effect. SNARE interactions in vesicular transport and neurotrophin signaling and FoxO signaling pathways in glucose metabolism are probably the mechanisms responsible for side effects of Doxorubicin. Conclusion: Following our model validation using the existing experimental data, we recommend our other newly predicted biomarkers and pathways as possible molecular mechanisms and side effects underlying the response to Doxorubicin in breast cancer requiring further investigations.

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“…Hirata et al 21 evaluated clinical and pathological factors in breast cancer patients and their relationship with HTLV-1 infection. There was no clinical or pathological aspect in this cancer related to HTLV-1, including the disease-free time and total survival, unless the patients infected with HTLV-1 were older.…”

Section: Discussionmentioning

confidence: 99%

Small cells lung epidermoid carcinoma in a HTLV1-infected patient: case report and literature review

Dahy

Palhares

Assone

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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Clinical Features of Breast Cancer Patients with Human T-Cell Lymphotropic Virus Type-1 Infection

Cited by 7 publications

References 11 publications

Association Between HTLV-1 Infection and Nasopharyngeal Carcinoma: A Case-Control Study

Association Between HTLV-1 Infection and Nasopharyngeal Carcinoma: A Case-Control Study

A Motif-Based Network Analysis of Regulatory Patterns in Doxorubicin Effects on Treating Breast Cancer, a Systems Biology Study

Small cells lung epidermoid carcinoma in a HTLV1-infected patient: case report and literature review

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