Human T-cell leukaemia/lymphoma virus type 1-associated infective dermatitis in Africa: a report of five cases from Senegal

Mahé, A.; Meertens, Laurent; Ly, Fatimata; Sow, P S; Diop, Cheikh Tacko; Samb, N. D.; Diop, Ousmane M.; Valensi, Françoise; Gessain, Antoine

doi:10.1111/j.1365-2133.2004.05834.x

Cited by 50 publications

(44 citation statements)

References 28 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They constituted more specifically a highly phylogenetically supported clade (bootstrap of 90% in the neighbor-joining analysis), located between the northern African and the western African HTLV-1 subgroups (Fig. 2) and comprising most of the other HTLV-1 strains known from Senegal (20).…”

mentioning

confidence: 99%

“…This has led to some overestimation of the HTLV-1 seroprevalence in several African areas. Thus, even up to now, there are only a few studies on HTLV-1 infection in the African continent in which the authors used stringent serological and/or molecular criteria for the diagnosis of HTLV-1 infection (18,20,21,23). Moreover, most of the epidemiological studies have been performed in hospitalized patients or in individuals at risk for acquiring HTLV-1 (prostitutes, human immunodeficiency virus [HIV]-infected patients, etc.)…”

mentioning

confidence: 99%

“…The objectives of the present study were thus to perform a seroepidemiological and a molecular study of HTLV-1 in a large population of blood donors from Senegal, a country of western Africa where ATL, TSP/HAM, and infective dermatitis cases have been reported (19,20,22,24,27).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Seroprevalence and Molecular Epidemiology of Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2 in Blood Donors from Dakar, Senegal

et al. 2006

View full text Add to dashboard Cite

In 2002, human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 seroprevalence was 0.16% (8/4,900) in blood donors from Dakar, Senegal. Most of the positive donors originated from the country's southern region. Seven donors were infected by HTLV-1 (of cosmopolitan subtype), and one was infected by HTLV-2. These data highlight the problem of transfusion safety in this area where HTLV-1-associated lymphoproliferative and neurological diseases are endemic.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Seroprevalence and Molecular Epidemiology of Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2 in Blood Donors from Dakar, Senegal

et al. 2006

View full text Add to dashboard Cite

show abstract

“…HTLV-1 is the causative agent of adult T-cell leukemia/lymphoma (ATL) (46) and tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) (15). It has also been associated with a number of inflammatory diseases, including pediatric infectious dermatitis (29,32), uveitis (37), and some cases of myositis (38,44). HTLV-2 may be responsible for rare neurological syndromes that are clinically related to TSP/HAM (22,40), but no tumors have been linked definitively to such infection (12,23).…”

mentioning

confidence: 99%

New Insights into Prevalence, Genetic Diversity, and Proviral Load of Human T-Cell Leukemia Virus Types 1 and 2 in Pregnant Women in Gabon in Equatorial Central Africa

et al. 2008

View full text Add to dashboard Cite

Human T-cell leukemia virus type 1 (HTLV-1) is highly endemic in areas of central Africa; mother-to-child transmission and sexual transmission are considered to be the predominant routes. To determine the prevalence and subtypes of HTLV-1/2 in pregnant women in Gabon, we conducted an epidemiological survey in the five main cities of the country. In 907 samples, the HTLV-1 seroprevalence was 2.1%, which is lower than that previously reported. Only one case of HTLV-2 infection was found. The HTLV-1 seroprevalence increased with age and differed between regions (P < 0.05), with the highest prevalence (5%) in the southeastern region. A wide range of HTLV-1 proviral loads was observed among the infected women. The level of the proviral load was correlated with a high HTLV-1 antibody titer (P < 0.02). Sequencing of HTLV-1 env and long terminal repeat fragments showed that all but one strain belonged to the central African subtype B; the outlier was of cosmopolitan subtype A. The new strains of subtype B exhibited wide genetic diversity, but there was no evidence of clustering of specific genomes within geographical regions of the country. Some strains were closely related to simian T-cell leukemia virus type 1 strains of great apes, suggesting that in these areas some HTLV-1 strains could arise from relatively recent interspecies transmission. The sole HTLV-2 strain belonged to subtype B. In this study we showed that the prevalence of HTLV-1 in the southeast is one of the highest in the world for pregnant women.

show abstract

“…27 Smaller series of cases have been described in Trinidad and Tobago, 29 Peru 30 and Senegal. 31 Curiously, in Japan,…”

Section: Htlv-i-associated Infective Dermatitismentioning

confidence: 99%

Manifestações infanto-juvenis da infecção pelo vírus linfotrópico de células T humanas (HTLV-I)

Bittencourt¹,

Primo²,

Oliveira³

2006

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

Objectives: To review the literature on diseases linked with infection by human T-cell lymphotropic virus type I (HTLV-I) in childhood and adolescence, with focus on clinical aspects, diagnosis, pathogenesis, progression and treatment.Sources: Medical literature published during the last 20 years identified using PubMed and MEDLINE and from specialized medical books, with emphasis on infective dermatitis associated with HTLV-I (IDH), on the juvenile form of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP), on adult T-cell leukemia/lymphoma (ATL) and on HTLV-I-associated uveitis. Keywords used to search databases were: HTLV-I-associated infective dermatitis, HTLV-Iassociated myelopathy/tropical spastic paraparesis, adult T-cell leukemia/lymphoma, HTLV-I-associated uveitis.Summary of the findings: IDH is a chronic, relapsing and infected dermatitis of childhood which always involves the scalp and which may progress to HAM/TSP and ATL. HAM/TSP is a chronic and incapacitating myelopathy of adults. There are 17 well-documented cases of HAM/TSP in children and adolescents in the literature, 12 of whom are patients with IDH. In contrast with the adult form of the disease, the juvenile form is rapid and progressive. ATL is a type of Tcell leukemia/lymphoma that affects adults and is generally fatal. Eleven of the 24 published reports of ATL in children and adolescents were diagnosed in Brazil.Conclusions: These diseases are likely to be more common in childhood and adolescence than the literature would suggest. It is advisable that serological testing be performed for HTLV-I in children and adolescents suffering from chronic and relapsing eczema, with signs and symptoms of myelopathy or with a diagnosis of T-cell leukemia/lymphoma. It is important that pediatricians know how to recognize the pediatric manifestations of this infection in order to correctly diagnose them and offer their patients appropriate guidance and treatment.

show abstract

Human T-cell leukaemia/lymphoma virus type 1-associated infective dermatitis in Africa: a report of five cases from Senegal

Cited by 50 publications

References 28 publications

Seroprevalence and Molecular Epidemiology of Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2 in Blood Donors from Dakar, Senegal

Seroprevalence and Molecular Epidemiology of Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2 in Blood Donors from Dakar, Senegal

New Insights into Prevalence, Genetic Diversity, and Proviral Load of Human T-Cell Leukemia Virus Types 1 and 2 in Pregnant Women in Gabon in Equatorial Central Africa

Manifestações infanto-juvenis da infecção pelo vírus linfotrópico de células T humanas (HTLV-I)

Contact Info

Product

Resources

About