Human single-donor composite skin substitutes based on collagen and polycaprolactone copolymer

Dai, Niann‐Tzyy; Yeh, Ming–Kung; Chiang, Chiao–Hsi; Chen, Ke-Chi; Liu, Tsung-Hsun; Feng, An‐Chieh; Chao, Li-Lien; Shih, Chien-Ming; Sytwu, Huey‐Kang; Chen, Shao‐Liang; Chen, Tim‐Mo; Adams, Eric F.

doi:10.1016/j.bbrc.2009.05.123

Cited by 18 publications

(8 citation statements)

References 10 publications

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“…PCL, since it exhibits good mechanical properties, a slow degradation rate and easy processing ability, has been blended with natural polymers (i.e. gelatin, collagen) in order to tune the desired mechanical properties and biodegradation rate for the realization of epidermal and bi-layer skin substitutes [17,18]. CHT-PCL blends have been tested for skin applications, as a potential wound dressing and to heal burns and cuts [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Polymeric membranes modulate human keratinocyte differentiation in specific epidermal layers

Salerno

Morelli

Giordano

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Section: Introductionmentioning

confidence: 99%

Polymeric membranes modulate human keratinocyte differentiation in specific epidermal layers

Salerno

Morelli

Giordano

et al. 2016

Colloids and Surfaces B: Biointerfaces

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“…9 Poly-e-caprolactone is being extensively investigated as a scaffold and drug delivery agent in tissue engineering because of its biocompatibility and efficacy. [10][11][12][13][14][15][16] One of the challenges that we have faced in our previous work is the opacity of PCL membranes. Hence, in the present study we addressed this issue by enhancing the transparency of scaffolds by using plasma discharge treatment.…”

mentioning

confidence: 99%

Surface-Modified Electrospun Poly(ε-Caprolactone) Scaffold With Improved Optical Transparency and Bioactivity for Damaged Ocular Surface Reconstruction

Sharma

Gupta²,

Mohanty

et al. 2014

Invest. Ophthalmol. Vis. Sci.

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“…The group of scientists from Great Britain and Taiwan [72,73,74] synthesized a copolymer fi lm using the combination of collagen and poly-ε-caprolactone (PCL) in 1:20 ratio. The latter is a biocompatible polymer [75], capable of enzymatic biodegradation [76].…”

Section: The Elaboration Of Matrices Using Collagenmentioning

confidence: 99%

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2015

Biopolym. Cell

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Currently, the development and the implementation of the new biotechnological wound coverings (skin equivalents) designed for temporal or permanent replacement of damaged or destroyed areas of human skin remains extremely actual relevant in clinical practice. Skin equivalents or equivalents of individual skin layers which include alive cells of different types take a special place among the artifi cial wound coverings. They mostly contain two basic types of cells -fi broblasts and keratinocytes (together or separately). Such bioconstructions are usually served as temporary coverings, which supply the damaged skin by biologically active substances and stimulate the regeneration of the patient's own tissues. In this review we consider as commercially available wound coverings and those which are still studied in the laboratories. Until now ideal substitutes of natural skin have not yet created, so the efforts of many researchers are focusing on the solution of this problem. K e y w o r d s: artifi cial skin, skin equivalents or substitutes, wound dermal coverages, tissue engineering, cell, wound.

show abstract

Human single-donor composite skin substitutes based on collagen and polycaprolactone copolymer

Cited by 18 publications

References 10 publications

Polymeric membranes modulate human keratinocyte differentiation in specific epidermal layers

Polymeric membranes modulate human keratinocyte differentiation in specific epidermal layers

Surface-Modified Electrospun Poly(ε-Caprolactone) Scaffold With Improved Optical Transparency and Bioactivity for Damaged Ocular Surface Reconstruction

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