Human rhinovirus infections in hospitalized children: clinical, epidemiological and virological features

Tran, Dinh Nguyen; Trinh, Quang Duy; Pham, Ngan Thi Kim; Pham, Thi Minh Hong; Ha, Manh Tuan; Nguyen, Nhu T. Q.; Okitsu, Shoko; Shimizu, Hiroyuki; Hayakawa, Satoshi; Mizuguchi, Masashi; Ushijima, Hiroshi

doi:10.1017/s0950268815000953

Cited by 24 publications

(20 citation statements)

References 32 publications

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“…During the same period, in some developed countries such as the USA, European countries, RSV, influenza and HMPV became completely undetectable. HRV has been reported to be one of the main pathogens causing upper RTIs, with a PDR as high as 10-30% [15]. This finding is inconsistent with our research, which observed the PDR of HRV to be less than 5%, indicating it is not a common pathogen in RTIs.…”

Section: Discussioncontrasting

confidence: 99%

“…The data were divided into different groups according to the immunization capacity and national vaccination plan in China. Children who were 14-year-old were categorized into three subgroups (0-1, 2-6, and 7-14 years), and individuals > 14-year old was subdivided into three subgroups (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50), and 51 years). The percentages of individuals in each of these age subgroups were 28.72%, 32.51%, 6.90%, 13.07%, 9.07%, and 9.7%, respectively.…”

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confidence: 99%

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New Epidemiological and Clinical Signatures of 18 Pathogens from Respiratory Tract Infections Based on a 5-Year Study

Liao

Liu

et al. 2015

PLoS ONE

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BackgroundRespiratory tract infections (RTIs) are a heavy burden on society. However, due to the complex etiology of RTIs, the clinical diagnosis, treatment, and prevention of these infections remain challenging, especially in developing countries.MethodsTo determine the epidemiological and clinical characteristics of 18 respiratory pathogens, we analyzed 12,502 patients with acute respiratory infections (ARIs) by performing polymerase chain reaction (PCR) on patient pharyngeal swabs.ResultsSamples positive for at least 1 pathogen were obtained from 48.42% of the total patients. Of these pathogen-positive patients, 17.99% were infected with more than 1 pathogen. Of the 18 pathogens analyzed, four were detected with a positive detection rate (PDR) > 5%: influenza A virus (IAV) > respiratory syncytial virus (RSV) >Mycoplasma pneumoniae (MP) > human coronavirus (HCoV). The pathogens with the 4 highest co-infection rates (CIRs) were as follows: HCoV > human bocavirus (HBoV) > enterovirus (EV) > parainfluenza virus (PIV). The overall positive detection rate (PDR) varied significantly according to patient age, the season and year of detection, and the disease subgroup, but not according to patient sex. The individual PDRs of the pathogens followed 3 types of distributions for patient sex, 4 types of distributions for patient age, 4 types of seasonal distributions, 2 types of seasonal epidemic trends, 4 types of yearly epidemic trends, and different susceptibility distributions in the disease subgroups. Additionally, the overall CIR showed significantly different distributions according to patient sex, patient age, and the disease subgroup, whereas the CIRs of individual pathogens suggested significant preference characteristics.ConclusionIAV remains the most common pathogen among the pathogens analyzed. More effort should be directed toward the prevention and control of pathogens that show a trend of increasing incidence such as HCoV, human adenovirus (ADV), and RSV. Although clinically distinguishing specific pathogens responsible for RTIs is difficult, the epidemiological and clinical characteristics of the various RTI-causing agents could provide clues for clinicians, thereby informing decisions regarding prevention and medication and guiding appropriate public health strategies.

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Section: Discussioncontrasting

confidence: 99%

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confidence: 99%

New Epidemiological and Clinical Signatures of 18 Pathogens from Respiratory Tract Infections Based on a 5-Year Study

Liao

Liu

et al. 2015

PLoS ONE

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“…These results suggest that most RVs are widespread, which is in agreement with previous reports that also describe the simultaneous circulation of a high number of types [20,24,25]. Nevertheless, some types have repeatedly been detected at higher frequencies than other types over the world [14,22,26,27]. Most of these types were also present at intermediate-to-high frequency in our population, such as RV-A12, RV-A78, RV-A101, RV-B104, RV-C2, RV-C16 and RV-C43.…”

Section: Discussionsupporting

confidence: 92%

A molecular epidemiological perspective of rhinovirus types circulating in Amsterdam from 2007 to 2012

Linden

Bruning

Thomas

et al. 2016

Clinical Microbiology and Infection

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Rhinoviruses (RVs) are frequently detected respiratory viruses that cause mild common cold symptoms, but may also lead to more severe respiratory tract infections. The large number of RV types, classified into species A, B and C, hampers clear insights into the epidemiology and clinical significance of each RV type. The aim of this study was to map the circulation of RV types in the Amsterdam area. RV-positive nasopharyngeal and oropharyngeal samples, collected from 2007 to 2012 in the Academic Medical Centre (Amsterdam, the Netherlands), were typed based on the sequence of the region coding for capsid proteins VP4 and VP2. RV-A, RV-B and RV-C were found in proportions of of 52.4% (334/637), 11.3% (72/637), and 36.2% (231/637), respectively. We detected 129 of the 167 currently classified types. RVs circulated throughout the entire year with a peak in the autumn and a decline in the summer. Some RV types were observed throughout the entire sampling period and others had a more seasonal pattern. Nine RV-A and four RV-B novel provisionally assigned types were identified. This study provides an insight into the molecular epidemiology of RVs in the Amsterdam area. The RVs circulating are diverse and include several provisionally new types.

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“…[16]. RSV and EV/ Rhi were the most frequent viruses, which was similar to the findings of a study done in Southern Vietnam [6].…”

Section: Discussionsupporting

confidence: 90%

“…Viruses are the main causative agents of respiratory infection, but bacteria, fungi, and parasites can cause them as well. e leading ARI-causing viruses are rhinovirus and respiratory syncytial virus (RSV) [4], with RSV affecting mainly infants under 1 year of age [5,6].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Pathogenic Characteristics of Lower Respiratory Tract Infection Treated at the Vietnam National Children’s Hospital

Pham

Nguyen

Tran

et al. 2020

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Lower respiratory tract infections are commonly caused by viruses and cause significant morbidity and mortality among children. Early identification of the pathological agent causing these infections is essential to avoid unnecessary antibiotic use and improve patient management. Multiplex PCR techniques were recently developed to detect multiple viral pathogens using a single PCR reaction. In this study, we identify viral pathogens in children with respiratory infections. We collected 194 nasopharyngeal aspirates from infants (2-24 months old) with lower respiratory tract infections treated at the Vietnam National Children's Hospital between November 2014 and June 2015 and assessed the presence of 16 virus types and subtypes by multiplex PCR using the xTAG Respiratory Viral Panel (RVP) assay. Overall, 73.7% of the samples were positive for at least one virus, and 24.2% corresponded to infections with multiple viruses. e most common viruses were respiratory syncytial virus and enterovirus/ rhinovirus. ese viruses were more frequent among younger patients (2-5 months old) and caused symptoms similar to those of bronchiolitis and pneumonia. e most common clinical manifestation caused by respiratory tract infection was bronchiolitis. Elevated neutrophils levels were associated with adenovirus infection. Our results showed that the xTAG Respiratory Viral Panel (RVP) can effectively detect multiple viruses causing respiratory infections in children and that the nasopharyngeal aspirates are a good sample choice to detect respiratory viruses in children. Applying this approach in the clinical setting would improve patient management and allow early diagnosis, thus avoiding the unnecessary use of antibiotics.

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Human rhinovirus infections in hospitalized children: clinical, epidemiological and virological features

Cited by 24 publications

References 32 publications

New Epidemiological and Clinical Signatures of 18 Pathogens from Respiratory Tract Infections Based on a 5-Year Study

New Epidemiological and Clinical Signatures of 18 Pathogens from Respiratory Tract Infections Based on a 5-Year Study

A molecular epidemiological perspective of rhinovirus types circulating in Amsterdam from 2007 to 2012

Clinical and Pathogenic Characteristics of Lower Respiratory Tract Infection Treated at the Vietnam National Children’s Hospital

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