Human Prolactin and Growth Hormone Release during Surgery and other Conditions of Stress<sup>1</sup>

Gl, Noel; Hk, Suh; Jg, Stone; Ag, Frantz

doi:10.1210/jcem-35-6-840

Cited by 566 publications

(165 citation statements)

References 1 publication

Supporting

Mentioning

138

Contrasting

Unclassified

Order By: Relevance

“…The results obtained for plasma prolactin concentrations in the present investigation support these of Malarkey' et al (1977) in that higher levels were observed in pre-but not postmenopausal breast cancer patients. Although stress has been reported to be a major factor in stimulating prolactin release (Noel et al, 1972) it is unlikely that differences in stress are the cause of the results reported here. None of the patients knew of their diagnosis prior to surgery, confirmation of malignant disease only being made following removal of the tumour.…”

Section: Discussionmentioning

confidence: 53%

Plasma lipids and prolactin in patients with breast cancer

Bani¹,

Williams²,

Boulter³

et al. 1986

Br J Cancer

View full text Add to dashboard Cite

Summary In a comparative study of pre-and postmenopausal women with benign and malignant breast disease, a number of differences were observed in circulating plasma prolactin and lipid concentrations. Plasma lipids, phospholipids, triglycerides, cholesterol and free fatty acids were all higher in blood obtained from breast cancer patients prior to surgery. HDL-Cholesterol levels were significantly lower in these patients. These differences remained when the patient groups were sub-divided according to menopausal status. Plasma prolactin concentrations were also found to be higher in cancer compared with non-cancer patients, this effect being more marked in premenopausal than in postmenopausal patients. Premenopausal patients with invasive or poorly differentiated disease had significantly higher prolactin levels than those with non-invasive disease. No correlations were found between plasma prolactin and any of the lipid fractions.

show abstract

Section: Discussionmentioning

confidence: 53%

Plasma lipids and prolactin in patients with breast cancer

Bani¹,

Williams²,

Boulter³

et al. 1986

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…The progesterone and prolactin levels in the peripheral blood during the cycle in which hysterectomy was performed (group II) are shown in Figure 2 and 3a. Hysterectomy was performed on D8, 10, 11, 12, and 16. Immediately after hysterectomy the progesterone levels decreased from 25-50% of the presurgical levels and returned to presurgical values within a few days in four out of the five dogs.…”

Section: Resultsmentioning

confidence: 96%

“…This may be due to anaesthesia and/or surgery, since a similar pattern was observed after sham surgery. Certain anaesthetics raise prolactin levels in the rat (15) and in man (16). A relationship may exist between this temporary decrease in the progesterone level and the high prolactin levels.…”

Section: Discussionmentioning

confidence: 99%

Evidence for the non‐involvement of the uterus in the lifespan of the corpus luteum in the cyclic dog

Okkens

Dieleman

Bevers

et al. 1985

Veterinary Quarterly

View full text Add to dashboard Cite

SUMMARY Progesterone levels in peripheral blood of dogs were analysed during the cycle in which hysterectomy (n= 5) or sham surgery (n = 3) was performed as well as during the cycle of dogs (n = 5) hysterectomized at least one year prior to this study; the data were compared with the findings in control dogs (n=3). The averages of the duration of the luteal period observed in the three experimental groups were not significantly different from those of control dogs. Immediately after surgery, the progesterone level decreased from 25 to 50% of the presurgical level, but returned to presurgical level in about four days. Prolactin levels were elevated for about 30 h after surgery. Nevertheless, the averages of the mean prolactin levels for each animal during the luteal period of the experimental groups were not significantly different from those of control dogs. It is concluded that in the dog, the uterus is not involved in the lifespan of the cyclic corpus luteum.

show abstract

“…Differences in precipitating factors, e.g. stress [11], or in drug usage could account for the discrepancies between the two studies.…”

Section: Discussionmentioning

confidence: 92%

Prolactin response to TRH in diabetic ketoacidosis

Naeije

Badawi²,

Vanhaelst³

et al. 1979

Diabetologia

View full text Add to dashboard Cite

Summary. The prolactin response to 200 gg thyrotropin-releasing hormone (TRH) IV was studied in seven patients with diabetic ketoacidosis, at the start of the treatment, and again, in the same patients, five days after recovery, when the diabetes was well controlled. Normal basal prolactin concentrations and prolactin responses to TRH were found in both situations. There was no correlation between basal prolactin concentrations, or magnitude of prolactin responses to TRH, and any of the metabolic variables measured. These findings do not suggest a role for prolactin in the development of diabetic ketoacidosis.Key words: Prolactin, diabetic ketoacidosis, plasma sodium, plasma osmolality, TRH test.Prolactin is said to have diabetogenic properties [1,2] and, in several animal species, plays a role in sodium and water retention [3]. Elevated prolactin concentrations have been reported in diabetic ketoacidosis and it was suggested that prolactin might participate in sodium retention in this condition [4].We recently showed that patients with diabetic ketoacidosis have an abnormally low thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH), in the face of reduced thyroxine (T4) and triiodothyronine (T3) concentrations [5]. Since TRH is also known to be a potent stimulator of prolactin secretion [6], it was considered of interest to investigate the reactivity of the pituitary prolactin cells to TRH in diabetic ketoacidosis. Material and MethodsSeven patients with severe diabetic ketoacidosis were studied, 5 men and 2 women, age range 20 to 74 years (37 _+ 7, mean _+ SEM), body weight range 82 to 117% of ideal body weight (96 _+ 4.5). The precipitating event was infection in 3 and omission of insulin in the others. None of the patients had clinical evidence of pituitary or thyroid disease. None of them used drugs known to affect prolactin secretion. Tests for glycosuria and ketonuria were strongly positive. Plasma glucose ranged from 400 to 830 mg/dl (615 _+ 60 mg/dl, mean _+ SEM); arterial blood pH from 6.80 to 7.21 (7.06 + 0.05); plasma sodium from 119 to 143 mmol/1 (130 + 3); plasma osmolality from 299 to 320 mOsm/kg (315 _+ 4); and plasma bicarbonate from 2 to 5.5 mmol/1 (3.5 __ 0.5). Five of the patients have been reported elsewhere, in a study on thyroid function in diabetic ketoacidosis [5]. All the patients were treated with a standard regimen as described previously, the insulin dosage being 20 IU/hr [7]. The mean duration of treatment was 6 h. Once the plasma glucose had reached 250 mg/dl, the patients received a 2000-2500 kcal diabetic diet and subcutaneous insulin according to glycosuria. After an average of 24 h, good control of the diabetes was achieved (i. e. no ketonuria and plasma glucose below 300 mg/dl).Synthetic thyrotropin-releasing hormone (TRH, Roche Laboratories) 200 ~tg was injected IV on admission, at the same time as the first insulin bolus, and again after 5 days good control of the diabetes. Blood was drawn at -15, 0, 15, 30, 45, 60, 90, and 120 min for prolactin determinations. ...

show abstract

Human Prolactin and Growth Hormone Release during Surgery and other Conditions of Stress¹

Cited by 566 publications

References 1 publication

Plasma lipids and prolactin in patients with breast cancer

Plasma lipids and prolactin in patients with breast cancer

Evidence for the non‐involvement of the uterus in the lifespan of the corpus luteum in the cyclic dog

Prolactin response to TRH in diabetic ketoacidosis

Contact Info

Product

Resources

About

Human Prolactin and Growth Hormone Release during Surgery and other Conditions of Stress1

Cited by 566 publications

References 1 publication

Plasma lipids and prolactin in patients with breast cancer

Plasma lipids and prolactin in patients with breast cancer

Evidence for the non‐involvement of the uterus in the lifespan of the corpus luteum in the cyclic dog

Prolactin response to TRH in diabetic ketoacidosis

Contact Info

Product

Resources

About

Human Prolactin and Growth Hormone Release during Surgery and other Conditions of Stress¹