Human pregnancy‐specific beta₁‐globulin and its relation to chorioepithelioma

Abstract

Human serum pregnancy-specific beta1-globulin (beta1-GP) was localized in paraffin sections of placenta and chorioepithelioma of the uterus by indirect immunofluorescence. The structures containing beta1-GP but not human serum albumin were regarded as specifically associated with beta1-GP metabolism. Beta1-GP was found in trophoblastic cells of chorion and Langhans cells of chorioepithelioma. Using the immunoautoradiographic method (I131), we only found beta1-GP in sera of patients with trophoblastic tumours: in 74.3% of 35 patients with chorioepithelioma and in 80% of 25 patients with hydatidiform mole and destructive hydatidform mole. The diagnostic and prognostic significance of the immunochemical test for beta1-GP in trophoblastic tumours is discussed.

The diagnostic value of circulating trophoblast-specific β1-glycoprotein (TSG) in cancer patients

“…Subsequently, TSG was discovered in the serum of patients with trophoblastic (Tatarinov et al, 1974) and testicular tumours (Tatarinov et al, 1975;Johnson et al, 1977) and in non-trophoblastic malignancies (Horne et al, 1976;Tatarinov & Sokolov, 1977) and the frequency of raised levels of TSG was compared with HCCG in these tumour groups Seppala et al, 1978;Searle et al, 1978;Tatarinov et al, 1976;Johnson et al, 1977;Wuirz et al, 1979).…”

“…The detection of TSG in the sera of 7000 of patients with gestational trophoblast tumours, including uterine choriocarcinomas, suggests that this immunochemical test for TSG may have diagnostic value. The correlation of TSG and human chorionic gonadotrophin (hCG) release by gestational trophoblast tumours has been discussed by a number of authors (Tatarinov et al, 1976;Bagshawe et al, 1978;Searle et al, 1978;Seppala et al, 1978;Than et al, 1979). From these data it would be reasonable to assume that TSG assays may play an ancillary role to hCG assays for such lesions.…”

“…From these data it would be reasonable to assume that TSG assays may play an ancillary role to hCG assays for such lesions. However, assays for TSG alone have an important role in epidemiological investigations, particularly in population groups with a high risk of trophoblast disease (Tatarinov et al, 1976). The relationship of high serum TSG levels to the function of the various histological subtypes of both choriocarcinomas (Tatarinov et al, 1976;Zavadil, 1974) and teratomas is now under active study.…”

Elevated Sera Levels of SP-1 Induced by Chemotherapy in Patients with Metastatic Gestational Trophoblastic Diseases

“…Comprehensive seromonitoring of patients with gestational trophoblastic disease (GTD) is carried out in our clinic to ensure close follow-up and the early detection of relapse [1,2], Seromonitoring includes simultaneous determina tion of pregnancy-specific beta-1-glycoprotein (SP-1) [3][4][5][6] and human chorionic gonadotropin beta subunit (P-hCG) [7,8] levels, two glycoproteins synthesized by trophoblast [9,10]. Both have the same diagnostic value and complement each other [1,2,11].…”

Pregnancy-Specific β1 Glycoprotein (SP1) in the Cerebrospinal Fluid

“…Pregnancy-specific pi glycoprotein (SP1) is a protein of a molecular weight of 80,000 daltons, which is normally produced by the syncytiotrophoblast [1,2]. Its serum level in creases early during pregnancy and falls within 30 days after delivery.…”