Human Polyomaviruses and Papillomaviruses

Moens, Ugo

doi:10.3390/ijms19082360

Cited by 10 publications

(8 citation statements)

References 27 publications

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“…Among other gene-editing technologies, CRISPR/Cas9 was found to deliver new competencies in fighting against human infectious virus illnesses that convey a substantial risk to human health ( Moens, 2018 ) and increase the socioeconomic load on the public health organizations globally ( Doerflinger et al., 2017 ). Herein, we will discuss the anti-viral approach of CRISPR/Cas9 to manage the infectious potency of severe human viruses, including the human immunodeficiency virus type 1(HIV-1) and type 2 (HIV-2), Hepatitis B viral infection (HBV), human papillomaviruses (HPV), and other human herpesviruses, ( Figure 3 ).…”

Section: Applications Of Crispr/cas Technology In Targeting Viral And...mentioning

confidence: 99%

The State-of-the-Art of Gene Editing and its Application to Viral Infections and Diseases Including COVID-19

Hawsawi

Shams

Theyab

et al. 2022

Front. Cell. Infect. Microbiol.

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Gene therapy delivers a promising hope to cure many diseases and defects. The discovery of gene-editing technology fueled the world with valuable tools that have been employed in various domains of science, medicine, and biotechnology. Multiple means of gene editing have been established, including CRISPR/Cas, ZFNs, and TALENs. These strategies are believed to help understand the biological mechanisms of disease progression. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been designated the causative virus for coronavirus disease 2019 (COVID-19) that emerged at the end of 2019. This viral infection is a highly pathogenic and transmissible disease that caused a public health pandemic. As gene editing tools have shown great success in multiple scientific and medical areas, they could eventually contribute to discovering novel therapeutic and diagnostic strategies to battle the COVID-19 pandemic disease. This review aims to briefly highlight the history and some of the recent advancements of gene editing technologies. After that, we will describe various biological features of the CRISPR-Cas9 system and its diverse implications in treating different infectious diseases, both viral and non-viral. Finally, we will present current and future advancements in combating COVID-19 with a potential contribution of the CRISPR system as an antiviral modality in this battle.

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Section: Applications Of Crispr/cas Technology In Targeting Viral And...mentioning

confidence: 99%

The State-of-the-Art of Gene Editing and its Application to Viral Infections and Diseases Including COVID-19

Hawsawi

Shams

Theyab

et al. 2022

Front. Cell. Infect. Microbiol.

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“…HPV belongs to the Papovaviridae family and is a sexually transmitted virus that causes genital warts[ 139 ]. Some subtypes such as 16 and 18 showed high risk and may lead to malignancies [ 140 ].…”

Section: Viral Infections Determination Using Lfa Sensing Platformsmentioning

confidence: 99%

Lateral flow assays (LFA) as an alternative medical diagnosis method for detection of virus species: The intertwine of nanotechnology with sensing strategies

Sadeghi

Sohrabi

Hejazi

et al. 2021

TrAC Trends in Analytical Chemistry

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“…The HPV genome is roughly 8 kbp in length, encodes 9 or 10 open reading frames (ORFs) and includes eight early viral regulatory proteins (E1−E8) and two late capsid proteins (L1 and L2) (Ebrahimi et al, 2019). Since HPVs present epithelia tissue tropism (Harden and Munger, 2017), sexual transmission (Ryndock and Meyers, 2014), and oncogenic property (Moens, 2018), their important status between human diseases and public health must be emphasized. Continued high-risk type HPV (e.g., HPV-16 and HPV-18) infection is highly associated with the development of cervical cancers in women (Gupta and Mania-Pramanik, 2019).…”

Section: Human Papilloma Virusmentioning

confidence: 99%

The Use of CRISPR/Cas9 as a Tool to Study Human Infectious Viruses

Lin

Peng

et al. 2021

Front. Cell. Infect. Microbiol.

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Clustered regularly interspaced short palindromic repeats (CRISPR) systems are a set of versatile gene-editing toolkit that perform diverse revolutionary functions in various fields of application such as agricultural practices, food industry, biotechnology, biomedicine, and clinical research. Specially, as a novel antiviral method of choice, CRISPR/Cas9 system has been extensively and effectively exploited to fight against human infectious viruses. Infectious diseases including human immunodeficiency virus (HIV), hepatitis B virus (HBV), human papillomavirus (HPV), and other viruses are still global threats with persistent potential to probably cause pandemics. To facilitate virus removals, the CRISPR/Cas9 system has already been customized to confer new antiviral capabilities into host animals either by modifying host genome or by directly targeting viral inherent factors in the form of DNA. Although several limitations and difficulties still need to be conquered, this technology holds great promises in the treatment of human viral infectious diseases. In this review, we will first present a brief biological feature of CRISPR/Cas9 systems, which includes a description of CRISPR/Cas9 structure and composition; thereafter, we will focus on the investigations and applications that employ CRISPR/Cas9 system to combat several human infectious viruses and discuss challenges and future perspectives of using this new platform in the preclinical and clinical settings as an antiviral strategy.

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Human Polyomaviruses and Papillomaviruses

Abstract: n/a

Cited by 10 publications

References 27 publications

The State-of-the-Art of Gene Editing and its Application to Viral Infections and Diseases Including COVID-19

The State-of-the-Art of Gene Editing and its Application to Viral Infections and Diseases Including COVID-19

Lateral flow assays (LFA) as an alternative medical diagnosis method for detection of virus species: The intertwine of nanotechnology with sensing strategies

The Use of CRISPR/Cas9 as a Tool to Study Human Infectious Viruses

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