Human polyomavirus KI and WU in adults with community acquired pneumonia in The Netherlands, 2008–2009

Huijskens, Elisabeth G. W.; Erkel, Adriana J. M. van; Peeters, Marcel; Rossen, John W. A.

doi:10.1016/j.jcv.2010.09.002

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…Karolinska Institute polyomavirus (KIPyV) was discovered in 2007 using random PCR with respiratory samples of symptomatic patients (129), but its mode of transmission has not been established. Respiratory tract infections have been associated with the detection of KIPyV in respiratory samples of pediatric and adult immunocompetent patients (130)(131)(132) and transplant recipients (75,98,133,134), but evidence of proven pathology is still lacking. The seroprevalence rates are detailed in Table 1.…”

Section: Dna Viruses Double-stranded Dna Virusesmentioning

confidence: 99%

“…The mode of transmission of WUPyV has not been established. As with KIPyV, respiratory tract infections have been associated with the detection of WUPyV in respiratory samples of pediatric and adult immunocompetent patients (130)(131)(132) and transplant recipients (75,98,133,134), but evidence of proven pathology is still lacking. The seroprevalence rates are detailed in Table 1.…”

Section: Dna Viruses Double-stranded Dna Virusesmentioning

confidence: 99%

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Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

2020

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SUMMARY Viral primary infections and reactivations are common complications in patients after solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) and are associated with high morbidity and mortality. Among these patients, viral infections are frequently associated with viremia. Beyond the usual well-known viruses that are part of the routine clinical management of transplant recipients, numerous other viral signatures or genomes can be identified in the blood of these patients. The identification of novel viral species and variants by metagenomic next-generation sequencing has opened up a new field of investigation and new paradigms. Thus, there is a need to thoroughly describe the state of knowledge in this field with a review of all viral infections that should be scrutinized in high-risk populations. Here, we review the eukaryotic DNA and RNA viruses identified in blood, plasma, or serum samples of pediatric and adult SOT/HSCT recipients and the prevalence of their detection, with a particular focus on recently identified viruses and those for which their potential association with disease remains to be investigated, such as members of the Polyomaviridae, Anelloviridae, Flaviviridae, and Astroviridae families. Current knowledge of the clinical significance of these viral infections with associated viremia among transplant recipients is also discussed. To ensure a comprehensive description in these two populations, individuals described as healthy (mostly blood donors) are considered for comparative purposes. The list of viruses that should be on the clinicians’ radar is certainly incomplete and will expand, but the challenge is to identify those of possible clinical significance.

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Section: Dna Viruses Double-stranded Dna Virusesmentioning

confidence: 99%

Section: Dna Viruses Double-stranded Dna Virusesmentioning

confidence: 99%

Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

2020

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“…Respiratory samples from children hospitalized due to respiratory infection, were collected and analyzed at the Elisabeth Hospital, Tilburg, Netherlands (n = 168) and The Edinburgh Royal Infirmary (South-east of Scotland) (n = 1303) for routine respiratory virus screening. [13][14][15] Samples had been collected during 5 consecutive years. Samples in this study were selected from the complete set based on the following criteria: children who were hospitalized with acute respiratory tract illness and below the age of 2 years.…”

Section: Patient Samplesmentioning

confidence: 99%

The dominance of human coronavirus OC43 and NL63 infections in infants

Dijkman

Jebbink

Gaunt

et al. 2012

Journal of Clinical Virology

Self Cite

172

192

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HCoV-NL63 and HCoV-OC43 infections occur frequently in early childhood, more often than HCoV-HKU1 or HCoV-229E infections. HCoV-OC43 and HCoV-NL63 may elicit immunity that protects from subsequent HCoV-HKU1 and HCoV-229E infection, respectively, which would explain why HCoV-OC43 and HCoV-NL63 are the most frequently infecting HCoVs. There are no indications that infection by one of the HCoVs is more pathogenic than others.

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“…KIPyV and WUPyV are also incidentally detected in adults with community acquired pneumonia, in immunocompromised hosts, and in patients with lung cancer; they are more often found in patients suffering an underlying medical condition and coinfections with KIPyV and WUPyV with other respiratory viruses are common [92,103,104]. A recent study evaluating the prevalence and viral load of WUPyV and KIPyV in respiratory samples from immunocompromised and immunocompetent children showed that the prevalence of WUPyV and KIPyV is similar in hematology/oncology patients compared with that of the general pediatric population [105].…”

Section: Ki and Wu Polyomavirusesmentioning

confidence: 99%

The role of infections and coinfections with newly identified and emerging respiratory viruses in children

Debiaggi¹,

Canducci

Ceresola

et al. 2012

Virol J

107

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Acute respiratory infections are a major cause of morbidity in children both in developed and developing countries. A wide range of respiratory viruses, including respiratory syncytial virus (RSV), influenza A and B viruses, parainfluenza viruses (PIVs), adenovirus, rhinovirus (HRV), have repeatedly been detected in acute lower respiratory tract infections (LRTI) in children in the past decades. However, in the last ten years thanks to progress in molecular technologies, newly discovered viruses have been identified including human Metapneumovirus (hMPV), coronaviruses NL63 (HcoV-NL63) and HKU1 (HcoV-HKU1), human Bocavirus (HBoV), new enterovirus (HEV), parechovirus (HpeV) and rhinovirus (HRV) strains, polyomaviruses WU (WUPyV) and KI (KIPyV) and the pandemic H1N1v influenza A virus. These discoveries have heavily modified previous knowledge on respiratory infections mainly highlighting that pediatric population is exposed to a variety of viruses with similar seasonal patterns. In this context establishing a causal link between a newly identified virus and the disease as well as an association between mixed infections and an increase in disease severity can be challenging. This review will present an overview of newly recognized as well as the main emerging respiratory viruses and seek to focus on the their contribution to infection and co-infection in LRTIs in childhood.

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Human polyomavirus KI and WU in adults with community acquired pneumonia in The Netherlands, 2008–2009

Cited by 5 publications

References 11 publications

Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

The dominance of human coronavirus OC43 and NL63 infections in infants

The role of infections and coinfections with newly identified and emerging respiratory viruses in children

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