Human platelet alloantigens (HPAs): PCR‐SSP genotyping of a UK population for 15 HPA alleles

Jones, Des C.; Bunce, Michael; Fuggle, S; Young, N. J.; Marshall, Sara E.

doi:10.1111/j.1365-2370.2003.00426.x

Cited by 35 publications

(41 citation statements)

References 46 publications

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“…To avoid epidemiologic bias, non-Arab Bahrainis (Iranians or recently-naturalized Bahrainis) were excluded. The varied prevalence of the HPA polymorphisms was consistent with previous reports documenting the geographical heterogeneity in their distribution [3,5,6].…”

Section: Discussionsupporting

confidence: 91%

“…The prevalence of HPA-1b (24%) and HPA-2b (23%) were high among Bahrainis, compared with Africans [3], Asians [5,8], and Europeans [6], which was comparable to rates established for Saudi Arabia [9], Tunisia [10], and North African Berbers [7], suggesting that Arabian Peninsula-North Africa is focus of HPA-1b. The prevalence of HPA-3b (43%) was less selective, as prevalence rates among Bahrainis were comparable to Asians [5,8] and Europeans [6].…”

Section: Discussionmentioning

confidence: 63%

“…Although virtually absent from Europeans [6] and Asians [5,8], HPA-4b was present in lower frequency (7%) in Bahrain, and in neighboring Saudi Arabia [9]. Although the highest frequency of HPA-5b was reported in Africa (18.2-26.8%; 3) and Italy (23%), the frequency of HPA-5b in Bahrain (13%) was compared with Saudi Arabia [9] and UK [6], but higher than those seen in Asians, where 2-5% frequencies were reported [5,8].…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of HPA-3b (43%) was less selective, as prevalence rates among Bahrainis were comparable to Asians [5,8] and Europeans [6]. Although virtually absent from Europeans [6] and Asians [5,8], HPA-4b was present in lower frequency (7%) in Bahrain, and in neighboring Saudi Arabia [9].…”

Section: Discussionmentioning

confidence: 99%

“…The distribution of HPA genotypes is geographically and ethnically restricted. The prevalence of HPA5b and HPA-2b is high among Africans [3] but very low among Asians [4,5], while the frequency of HPA-1b is higher among Caucasians [6] and Berbers [7] than Asians [4,5]. In so far as data on the distribution of HPA polymorphisms among Arabs are scanty, the present study investigated the diversity in HPA alleles, genotypes, and haplotypes in Bahrain, an island kingdom located in the Arabian Gulf.…”

Section: Introductionmentioning

confidence: 94%

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Gene frequencies of human platelet alloantigens in Bahraini Arabs

et al. 2006

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Human platelet antigens (HPA) are implicated in the pathophysiology of certain hematological disorders, and as varied distribution of HPA-1 alleles and genotypes were reported for different countries and ethnic populations, we determined the distribution of HPA-1, -2, -3, -4, and -5 alleles, genotypes and haplotypes for 194 healthy Bahraini subjects by polymerase chain reaction with sequence specific primers. The distribution of the HPA polymorphisms was in Hardy-Weinberg equilibrium. Allele frequencies of 0.76 and 0.24 (HPA-1a and -1b), 0.77 and 0.23 (HPA-2a and -2b), 0.57 and 0.43 (HPA-3a and -3b), 0.93 and 0.07 (HPA-4a and -4b), and 0.86 and 0.13 (HPA-5a and -5b) were seen. With the exception of HPA-3a/a (30.4%), the frequencies of homozygous HPA1a/a (56.8%), 2a/a (60.1%), 4a/a (87.2%), and 5a/a (75.7%) were higher than those of heterozygous (a/b) or homozygous (b/b) variants. Our results provide basic information for further studies of the HPA system polymorphism, which in turn will be instrumental in understanding and treating immune-mediated platelet disorders. Am. J. Hematol. 82:242-244, 2007. V V C 2006 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

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Gene frequencies of human platelet alloantigens in Bahraini Arabs

et al. 2006

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Polymorphisms of the human platelet alloantigens HPA‐1, HPA‐2, HPA‐3, and HPA‐4 in ischemic stroke

et al. 2008

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Polymorphism in human platelet antigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa), and HPA-5 (GPIa/IIa) was investigated in 329 stroke patients and 444 matched control subjects. HPA genotyping was done by PCR-SSP method. Lower HPA-1a (P < 0.001) and higher HPA-1b (P < 0.001) allele frequencies were seen in patients than control subjects, and homozygosity for HPA-1b (P < 0.001) alleles was more prevalent in stroke cases than in controls. The allele and genotype distributions of the other HPA polymorphic variants were similar between cases and controls. Select HPA combined genotypes comprising the 2121 (Pc 5 0.008) and 2221 (Pc 5 0.018) genotypes, which were positively associated, and the 1111 (Pc < 0.001), which was negatively associated with stroke, thereby conferred a disease susceptibility and protective nature to these genotype combinations. Multivariate analysis confirmed the negative association of the 1111 (P < 0.001) and the positive association of the 2121 (P 5 0.017) combined genotypes with stroke, after adjustment for a number of covariates. This is the first evidence demonstrating differential association of the common 4 HPA gene variants and specific HPA genotype combinations with stroke. Am. J. Hematol. 83:570-573, 2008. V

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Human platelet alloantigens HPA-1, HPA-2, and HPA-3 polymorphisms associated with extent of severe coronary artery disease

Abboud

Ghazouani

Ben-Hadj-Khalifa

et al. 2009

J Thromb Thrombolysis

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The contribution of human platelet antigen (HPA)-1 (GPIIb/IIIa), HPA-2 (GPIb/IX), and HPA-3 (GPIIb/IIIa) polymorphisms to the risk of coronary artery disease (CAD) was investigated in 341 CAD patients and 316 matched control subjects. HPA genotyping was performed by PCR-SSP. Regression analysis was employed in assessing the contribution of these variants to CAD risk. The frequency of HPA-1b (P = .009) and HPA-3b (P = .004) alleles, and HPA-1a/1b (P = .045), HPA-1b/1b (P = .007), and HPA-3b/3b (P = .008) genotypes were higher in patients than control subjects. No significant association was demonstrated between the HPA variants and 1-, 2- and 3-vessel disease. HPA-1b/2a/3b (Pc = .021) and HPA-1b/2b/3a (Pc = .002) haplotypes were positively associated with CAD, thereby conferring a disease susceptibility nature to these haplotypes. Multivariate analysis confirmed the positive association of HPA-1b/2a/3b (aOR = 3.72; 95% CI = 1.49-9.28), and in addition identified HPA-1b/2a/3a (aOR = 2.49; 95% CI = 1.06-5.86) to be positively associated with CAD, after adjusting for a number of covariates. Our results demonstrate positive association of HPA variants and specific HPA-1/HPA-2/HPA-3 haplotypes with CAD in Tunisians.

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Human platelet alloantigens (HPAs): PCR‐SSP genotyping of a UK population for 15 HPA alleles

Cited by 35 publications

References 46 publications

Gene frequencies of human platelet alloantigens in Bahraini Arabs

Gene frequencies of human platelet alloantigens in Bahraini Arabs

Polymorphisms of the human platelet alloantigens HPA‐1, HPA‐2, HPA‐3, and HPA‐4 in ischemic stroke

Human platelet alloantigens HPA-1, HPA-2, and HPA-3 polymorphisms associated with extent of severe coronary artery disease

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