Human Plasma Paraoxonase 1 (PON1) Arylesterase Activity During Aging: Correlation with Susceptibility of LDL Oxidation

Age-Dependent Paraoxonase 1 (PON1) Activity and LDL Oxidation in Wistar Rats during Their Entire Lifespan

“…In a recent report on humans we reported a continuous decrease in plasma PON1 arylesterase activity starting from 20 years of age till 80 years [13]. It is of interest that in rats there is no significant change in PON1 arylesterase activity, plasma MDA, and radical scavenging activity till 8 weeks of age which is almost one-third of the total lifespan of 24 months.…”

“…Previous researches show that both LDL and HDL have an increased susceptibility to oxidation with age [12]. In a recent study we have shown a decrease in PON1 arylesterase activity in humans during aging which shows a correlation with the susceptibility of LDL oxidation [13]. …”

Paraoxonase 1 Activity in Patients with Chronic Obstructive Pulmonary Disease

“…First, small sample size (105 COPD patients, 44 healthy controls) is restrictive for an unambiguous conclusions, and a larger epidemiological study with age and gender matched healthy subject will be needed (48). Second, cross-sectional design of the study cannot definitively establish causal or temporal relationship, thus the longitudinal study is needed with following up the patients over time to evaluate the strength of the association between decreased PON1 activities and COPD development.…”

La PON1 est-elle un facteur du risque cardiovasculaire chez les diabétiques de type 2 ?

“…Cela concorde avec l'étude de Saruhan et al [9] mais pas avec celles de Marchegiani et al [10] et Dantoine et al [11] qui suggèrent une diminution liée au vieillissement. Cette diminution pourrait apporter une fragilité supplémen-taire chez les personnes âgées et constituer un facteur contributif à l'accroissement de la prévalence des maladies cardiovasculaires avec l'âge [12].…”