Human Plasma Monoamine Oxidase

McEwen, Charles M.

doi:10.1016/s0021-9258(18)97417-x

Cited by 174 publications

(4 citation statements)

References 17 publications

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“… − However, the pharmacological activity of aeruginascin remains unexplored. Finally, the polar primary amine norbaeocystin ( 4 ) would not be expected to reach the central nervous system (CNS) and contribute to psychedelic effects due to poor blood–brain barrier penetrability and/or rapid metabolism by monoamine oxidase (MAO), especially considering the structural similarity of its putative dephosphorylated metabolite, 4-hydroxytryptamine, to serotonin . Nevertheless, the availability of 4 may have utility in further elucidation and characterization of the enzymatic pathways involved in the biosynthesis of tryptamines in mushrooms as a reference standard.…”

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confidence: 99%

Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin

et al. 2020

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A general synthetic method was developed to access known tryptamine natural products present in psilocybinproducing mushrooms. In vitro and in vivo experiments were then conducted to inform speculations on the psychoactive properties, or lack thereof, of the natural products. In animal models, psychedelic activity by baeocystin alone was not evident using the mouse head twitch response assay, despite its putative dephosphorylated metabolite, norpsilocin, possessing potent agonist activity at the 5-HT 2A receptor. Article pubs.acs.org/jnp

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mentioning

confidence: 99%

Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin

et al. 2020

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“…The monoamine oxidase (MAO) activity was determined as previously reported (McEwen, 1965 ). 200 μL of fly tissue, 0.5 μmol/mL of benzylamine, 400 μL of 100 mM phosphate buffer (pH 7.4), and 1.3 mL of distilled water constituted the reaction mixture.…”

Section: Methodsmentioning

confidence: 99%

African Jointfir (Gnetum africanum) and Editan (Lasianthera africana) leaf alkaloid extracts exert antioxidant and anticholinesterase activities in fruit fly (Drosophila melanogaster)

Oboh

Atoki

Ademiluyi

et al. 2023

Food Science & Nutrition

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African Jointfir (Gnetum africanum) and Editan (Lasianthera africana) leaves are two leafy green veggies with several nutritional and medicinal properties. Alzheimer's disease (AD) is a form of neurodegeneration that is believed to cause dementia in affected individuals. The quest for alternative treatments has necessitated the exploitation of plants' secondary metabolites. Plant alkaloids have recently demonstrated relevance in the management of a variety of neurodegenerative disorders; although there is limited information on the neuroprotective properties of alkaloids from various tropical green leafy vegetables with neuroprotective potentials. As a result, this study examined the cholinesterase inhibitory activity and antioxidant potential of alkaloid extracts from the leaves of African Jointfir (G. africanum) and Editan (L. africana). Standard solvent extraction techniques were used to prepare alkaloid extracts. After that, these extracts were characterized using high‐performance liquid chromatography. In vitro acetylcholinesterase inhibition assay for the extracts was also carried out. Subsequently, the alkaloid extracts were included in the diets of these flies (2 and 10 μg/g) for 7 days. Thereafter, treated fly homogenates were assayed for cholinesterase, monoamine oxidase, and antioxidant enzymes (specifically, glutathione‐S‐transferase catalase, and superoxide dismutase) activities, in addition, thiobarbituric acid reactive substance, reactive oxygen species, and total thiol contents. The extracts showed considerable anticholinesterase, antioxidant, and antimonoamine oxidase capabilities, according to the study's findings. Also, HPLC characterization revealed that desulphosinigrin (597,000 ng/100 g) and atropine (44,200 ng/100 g) are the predominating phytochemicals in Editan and African Jointfir respectively. These extracts could serve as potential sources of nutraceuticals with neuroprotective properties which can be used in the treatment/management of Alzheimer's disease.

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“…The activity of MAO-B was estimated by the earlier described protocol. [31] Briefly, 700 µL of distilled water was added to 100 µL of phosphate buffer (pH 7.2) followed by 100 µL of benzylamine (50 mM) as the substrate with 100 µL of PRP. The kinetics activity was read out at 250 nm for 2.5 minutes.…”

Section: Assay Of Mao-a and Mao-bmentioning

confidence: 99%

Identification of markers of depression and neurotoxicity in pesticide exposed agriculture workers

Kori

Mandrah

Hasan

et al. 2020

J Biochem & Molecular Tox

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Earlier, we reported that chronic exposure to pesticides causes a reduction in the acetylcholinesterase activity and hematological and biochemical alterations in agriculture workers. In continuation with that, the present study aimed to investigate the pesticide‐induced neurochemical imbalance and its association with behavior alterations in agricultural workers. A significant increase in depressive symptoms, assessed by the Beck Depression Inventory‐II was observed in pesticide exposed workers as compared to the unexposed. A decrease in the level of dopamine in plasma and levels of dopamine, 3,4‐dihydroxyphenylacetic acid, homovanillic acids, norepinephrine, serotonin, and hydroxyindoleacetic acid in urine was also observed. An increase in the levels of MAO‐A and MAO‐B has also been observed in these individuals. The decreased levels of neurotransmitters in the blood and urine have been linked with increased levels of MAO and pesticide residues in plasma and urine. Furthermore, these changes were associated with a higher incidence of depression in agricultural workers.

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Human Plasma Monoamine Oxidase

Cited by 174 publications

References 17 publications

Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin

Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin

African Jointfir (Gnetum africanum) and Editan (Lasianthera africana) leaf alkaloid extracts exert antioxidant and anticholinesterase activities in fruit fly (Drosophila melanogaster)

Identification of markers of depression and neurotoxicity in pesticide exposed agriculture workers

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