Identification of markers of depression and neurotoxicity in pesticide exposed agriculture workers

Kori, Rajesh Kumar; Mandrah, Kapil; Hasan, Whidul; Patel, Devendra Kumar; Roy, Somendu Kumar; Yadav, Rajesh Singh

doi:10.1002/jbt.22477

Cited by 22 publications

(14 citation statements)

References 53 publications

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“…Chronic exposure of pesticides is associated with the risk of adverse clinical outcomes, as showed by the tingling, muscle pain, headache, sleep disorder, blurred vision, skin disease, and so forth [45]. The increased level of lipid peroxidation linked with decreased antioxidant defense system, suggesting the enhanced oxidative stress in agriculture workers [45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and DNA damage in agricultural workers after exposure to pesticides

Ledda

Cannizzaro

Cinà

et al. 2021

J Occup Med Toxicol

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Background Recent epidemiological studies on workers describe that exposure to pesticides can induce oxidative stress by increased production of free radicals that can accumulate in the cell and damage biological macromolecules, for example, RNA, DNA, DNA repair proteins and other proteins and/or modify antioxidant defense mechanisms, as well as detoxification and scavenger enzymes. This study aimed to assess oxidative stress and DNA damage among workers exposed to pesticides. Methods For this purpose, 52 pesticide exposed workers and 52 organic farmers were enrolled. They were assessed: the pesticide exposure, thiobarbituric acid reactive substances (TBARS), total glutathione (TG), oxidized glutathione levels (GSSG), and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), levels. Results Correlation between pesticide exposure was positively associated with high TBARS and 8-oxodG levels (p < 0.001). A negative association was founded with TG and GSSG and pesticide exposure. Conclusions The present investigation results seem to indicate a mild augment in oxidative stress associated with pesticide exposure, followed by an adaptive response to increase the antioxidant defenses to prevent sustained oxidative adverse effects stress.

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Section: Discussionmentioning

confidence: 99%

Oxidative stress and DNA damage in agricultural workers after exposure to pesticides

Ledda

Cannizzaro

Cinà

et al. 2021

J Occup Med Toxicol

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“…People working in agriculture have some of the highest rates of brain cancer and Parkinson’s disease [ 9 , 10 , 11 ], 46% greater odds of having dementia [ 12 ], and increased rates of anxiety, depression, and suicide [ 13 , 14 , 15 , 16 ]. These risks may be associated with central nervous system dysfunction; for example, agriculturalists have been found to experience a higher risk of impaired neurobehavioral, neuromotor, or neurocognitive performance [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Brain Health in Agricultural Work: A Systematic Review

Sturm

Castro

Mendez-Colmenares

et al. 2022

IJERPH

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Certain exposures related to agricultural work have been associated with neurological disorders. To date, few studies have included brain health measurements to link specific risk factors with possible neural mechanisms. Moreover, a synthesis of agricultural risk factors associated with poorer brain health outcomes is missing. In this systematic review, we identified 106 articles using keywords related to agriculture, occupational exposure, and the brain. We identified seven major risk factors: non-specific factors that are associated with agricultural work itself, toluene, pesticides, heavy metal or dust exposure, work with farm animals, and nicotine exposure from plants. Of these, pesticides are the most highly studied. The majority of qualifying studies were epidemiological studies. Nigral striatal regions were the most well studied brain area impacted. Of the three human neuroimaging studies we found, two focused on functional networks and the third focused on gray matter. We identified two major directions for future studies that will help inform preventative strategies for brain health in vulnerable agricultural workers: (1) the effects of moderators such as type of work, sex, migrant status, race, and age; and (2) more comprehensive brain imaging studies, both observational and experimental, involving several imaging techniques.

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“…When the ranking system was applied to occupational exposure studies, only PHYTONER [ 12 , 23 ] and Anger et al [ 24 ] studies scored as Tier 1. Seven studies were given rank as Tier 2 [ 16 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ], while seventeen studies were ranked as Tier 3 or Tier 4.…”

Section: Resultsmentioning

confidence: 99%

“…Sixteen out of twenty-six studies were cross-sectional; however, among Tier 1 and Tier 2 classes, only three out of nine were cross-sectional, with a sample size of over 200 participants. The question of the correlation between depression and anxiety in farmers and the level of exposure to insecticides in general among studies with Tier 2 ranking have been evaluated by Koh et al, Beard et al, Weisskopf et al, and Kori et al [ 28 , 29 , 30 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

Neurobehavioral Effects of Low-Dose Chronic Exposure to Insecticides: A Review

Antonangeli

Kenzhebekova

Colosio

2023

Toxics

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The modes of action of insecticides frequently involve a neurotoxic effect; therefore, the study of neurotoxic effects caused by long-term and low-dose insecticide exposure is of particular interest. This study looks at whether or not new studies conducted after 2009 and up to 2021 have provided new evidence for a better understanding of the actual neurobehavioral risk associated with long-term insecticide exposure. We selected and reviewed studies carried out on the neurobehavioral effects of neurotoxic insecticides (organophosphates and/or carbamates, pyrethroids, multiple or undefined insecticides, and organochlorines) considering occupational and non-occupational exposures. The articles were also scored and ranked based on seven parameters. Eighty-six studies were chosen for a final review process from among the 950 scientific papers identified. Twenty-six addressed occupational exposure and six environmental exposure. Among the latter group of studies, 17 focused on rural residents, to be assumed exposed because of living in rural areas, and 43 on the general population. Pending doubts have not been resolved in the last ten years due to the presence of contradictory and hardly comparable results and the fact that in most of the studies showing an evident neurobehavioral impairment the frequent presence of a previous episode of poisoning and hospitalization, with severe brain hypoxia, impaired the possibility of confirming the presence of a causal association with insecticide exposure. Interestingly, the most severely exposed groups, such as applicators who did not wear personal protective equipment, performed worse on neurobehavioral tests. As for residential exposure, there is sufficient evidence to suggest that prenatal OP exposure may increase the risk of ADHD in children.

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Identification of markers of depression and neurotoxicity in pesticide exposed agriculture workers

Cited by 22 publications

References 53 publications

Oxidative stress and DNA damage in agricultural workers after exposure to pesticides

Oxidative stress and DNA damage in agricultural workers after exposure to pesticides

Risk Factors for Brain Health in Agricultural Work: A Systematic Review

Neurobehavioral Effects of Low-Dose Chronic Exposure to Insecticides: A Review

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