Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages

Abumaree, Mohamed; Jumah, Mohammed Al; Kalionis, Bill; Jawdat, Dunia; Khaldi, Abdulaziz Al; Abomaray, Fawaz; Fatani, Abulhamed; Chamley, Larry; Knawy, B. A.

doi:10.1007/s12015-013-9455-2

Cited by 277 publications

(257 citation statements)

References 60 publications

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“…In agreement with several earlier results [21,49,50], the crosstalk between Ms and MSCs occur primarily by soluble factors, since cytokine production during physical separation of the two cell types was similar to those measured in direct co-cultures. One of the soluble factors produced by both Ms and MSCs is PGE-2.…”

Section: Discussionsupporting

confidence: 92%

Mesenchymal stem cells promote macrophage polarization toward M2b-like cells

Kudlik

Hegyi

Czibula

et al. 2016

Experimental Cell Research

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Section: Discussionsupporting

confidence: 92%

Mesenchymal stem cells promote macrophage polarization toward M2b-like cells

Kudlik

Hegyi

Czibula

et al. 2016

Experimental Cell Research

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“…[93][94][95][96] There are some similar experiments showing that MSCs from the other tissues also can polarize macrophages to the alternatively activated M2 phenotype. In parallel observation with human placental MSCs, Abumaree et al 97 also found that the human placental MSCs also have potent anti-inflammatory and immunosuppressive actions via converting macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype. At the same time, human gingiva-derived MSCs also have the same effects on the phenotype of macrophages.…”

mentioning

confidence: 77%

Anti-inflammatory effect of stem cells against spinal cord injury via regulating macrophage polarization

Zhang¹,

He²

2017

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Spinal cord injury (SCI) is a traumatic event that involves not just an acute physical injury but also inflammation-driven secondary injury. Macrophages play a very important role in secondary injury. The effects of macrophages on tissue damage and repair after SCI are related to macrophage polarization. Stem cell transplantation has been studied as a promising treatment for SCI. Recently, increasing evidence shows that stem cells, including mesenchymal stem, neural stem/progenitor, and embryonic stem cells, have an anti-inflammatory capacity and promote functional recovery after SCI by inducing macrophages M1/M2 phenotype transformation. In this review, we will discuss the role of stem cells on macrophage polarization and its role in stem cell-based therapies for SCI.

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“…In addition, our results indicate that trophoblast cells play a major role in this adaptation. Although other placental cells were reported to promote suppressive function in leukocytes (e.g., mesenchymal stem cells) (34,35), the numerical advantage and anatomical location of trophoblast cells render them the prime candidate for affecting maternal leukocytes in the adjacent decidua. Importantly, the trophoblast cell line HTR-8/ SVneo (20), which is widely used as a substitute for human primary trophoblast cells, only partially induced the regulatory cell types described above, and, contrary to placental tissue, it enhanced Th cell activation (likely due to its lack of IL-10 production).…”

Section: Foxp3mentioning

confidence: 99%

The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages

Svensson‐Arvelund

Mehta

Lindau

et al. 2015

The Journal of Immunology

239

236

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A successful pregnancy requires that the maternal immune system is instructed to a state of tolerance to avoid rejection of the semiallogeneic fetal-placental unit. Although increasing evidence supports that decidual (uterine) macrophages and regulatory T cells (Tregs) are key regulators of fetal tolerance, it is not known how these tolerogenic leukocytes are induced. In this article, we show that the human fetal placenta itself, mainly through trophoblast cells, is able to induce homeostatic M2 macrophages and Tregs. Placental-derived M-CSF and IL-10 induced macrophages that shared the CD14(+)CD163(+)CD206(+)CD209(+) phenotype of decidual macrophages and produced IL-10 and CCL18 but not IL-12 or IL-23. Placental tissue also induced the expansion of CD25(high)CD127(low)Foxp3(+) Tregs in parallel with increased IL-10 production, whereas production of IFN-gamma (Th1), IL-13 (Th2), and IL-17 (Th17) was not induced. Tregs expressed the suppressive markers CTLA-4 and CD39, were functionally suppressive, and were induced, in part, by IL-10, TGF-beta, and TRAIL. Placental-derived factors also limited excessive Th cell activation, as shown by decreased HLA-DR expression and reduced secretion of Th1-, Th2-, and Th17-associated cytokines. Thus, our data indicate that the fetal placenta has a central role in promoting the homeostatic environment necessary for successful pregnancy. These findings have implications for immune-mediated pregnancy complications, as well as for our general understanding of tissue-induced tolerance.

Funding Agencies|Medical Research Council [K2013-61X-22310-01-4]

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Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages

Cited by 277 publications

References 60 publications

Mesenchymal stem cells promote macrophage polarization toward M2b-like cells

Mesenchymal stem cells promote macrophage polarization toward M2b-like cells

Anti-inflammatory effect of stem cells against spinal cord injury via regulating macrophage polarization

The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages

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