2015
DOI: 10.4049/jimmunol.1401536
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The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages

Abstract: A successful pregnancy requires that the maternal immune system is instructed to a state of tolerance to avoid rejection of the semiallogeneic fetal-placental unit. Although increasing evidence supports that decidual (uterine) macrophages and regulatory T cells (Tregs) are key regulators of fetal tolerance, it is not known how these tolerogenic leukocytes are induced. In this article, we show that the human fetal placenta itself, mainly through trophoblast cells, is able to induce homeostatic M2 macrophages an… Show more

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Cited by 253 publications
(282 citation statements)
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“…CD206, also termed MRC1 (C-type mannose receptor 1), is a 175-kDa type I transmembrane glycoprotein that binds and internalizes glycoproteins and collagen ligands (Porcheray et al 2005). Several types of tissue-resident macrophages express CD206 in the mouse and the human, including ATMs (Aron-Wisnewsky et al 2009;Dupasquier et al 2006;Haase et al 2014;Svensson-Arvelund et al 2015;Titos et al 2011;Zeyda et al 2007). The immune functions of CD206 are not yet fully understood; for instance, its absence increases the random migration of macrophages and results in the up-regulation of proinflammatory cytokine production in the mouse (Kambara et al 2015).…”
Section: Discussionmentioning
confidence: 99%
“…CD206, also termed MRC1 (C-type mannose receptor 1), is a 175-kDa type I transmembrane glycoprotein that binds and internalizes glycoproteins and collagen ligands (Porcheray et al 2005). Several types of tissue-resident macrophages express CD206 in the mouse and the human, including ATMs (Aron-Wisnewsky et al 2009;Dupasquier et al 2006;Haase et al 2014;Svensson-Arvelund et al 2015;Titos et al 2011;Zeyda et al 2007). The immune functions of CD206 are not yet fully understood; for instance, its absence increases the random migration of macrophages and results in the up-regulation of proinflammatory cytokine production in the mouse (Kambara et al 2015).…”
Section: Discussionmentioning
confidence: 99%
“…It has been found that trophoblast secretory products reduce expression of STAT4 (specific for Th1 cells) transcription factors in T cells and stimulate expression of GATA3 and STAT6 (specific for Th2 cells) [63]. Secretory products of placenta, isolated cells of cytotrophoblast and syncytiotrophoblast stimulate CD4 [120]. During activation these cells secrete lower amount of cytokines than control cells, and show increased secretion of IL-10, which corresponds to decidua Treg characteristics at early stages of pregnancy [120].…”
Section: Impact Of Placenta and Decidua Cells On T Lymphocyte Functiomentioning
confidence: 99%
“…Treg Тh3 subpopulation is characterized by TGF-β and IL-10 secretion and FoxP3 expression [87]. CD4 + CD25 -alteration into Treg cells at the periphery (outside the thymus) occurs with obligatory B7 molecule co-stimulation [61], at activation through TcR [35] in cooperation with action of IL-10 and TGF-β cytokines [42,109,121], the source of which is the trophoblast in the zone of the uteroplacental bed [17,29,96,120]. Estradiol promotes Treg differentiation and increases their proliferation in response to activation through CD3/CD28 [131].…”
Section: Cd25mentioning
confidence: 99%
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