Human placenta as a ‘dual’ biomarker for monitoring fetal and maternal environment with special reference to potentially toxic trace elements.Part 2: Essential minor, trace and other (non-essential) elements in human placenta

Iyengar, G. V.; Rapp, Alfred

doi:10.1016/s0048-9697(01)00826-9

Cited by 50 publications

(28 citation statements)

References 32 publications

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“…It is important to state that the placental collection procedure employed by us is consistent with their recommendations, as outlined earlier (1); originally, it was adapted from (7). In Parts 2 and 3, these authors have tried to establish reference values for minor and trace elements (both essential and toxic) (5,6). The placental concentrations reported by us are in good agreement with the tabulations provided for 10 of the 16 elements, with our values being lower for Ni, Na and Mn and higher for S. Our results for Ba and Sr appear to be the first to have been determined and reported.…”

Section: Original Researchsupporting

confidence: 85%

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Elements in placenta and pregnancy outcome in arctic and subarctic areas

Odland

Nieboer

Romanova

et al. 2004

International Journal of Circumpolar Health

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Objectives. This paper describes a comprehensive assessment of the association of concentrations of essential and toxic elements in maternal and neonatal body fluids and the placenta as predictors of birth weight and newborn body mass index (BMIC) for deliveries in northern Norway and Russia. Study design. A prospective cross-sectional study of delivering women and their outcomes from different locations in Russian and Norwegian arctic and sub-arctic areas. Methods. Life-style information, blood, urine and placenta specimens were collected for 50 consecutive mother-infant pairs from hospital delivery departments in a total of six communities located in Finnmark, Norway, or the western arctic/subarctic regions of Russia. Questionnaire information was collected by individual interviews performed by trained health personnel. Pregnancy outcomes were verified by consulting medical records. Cadmium, copper, iron (as ferritin), nickel, lead, selenium and zinc were measured in maternal blood, serum or maternal urine; and in cord blood, or neonatal urine and placental tissue. Univariate and multivariate linear regression analysis and ANOVA were employed to explore associations between these clinical chemistry outcomes and birth weight and BMIC. Results. A number of significant relationships were evident between: placental and maternal blood cadmium (p < 0.005); cord and maternal blood lead (p < 0.001); placental and maternal blood lead (p < 0.001); placental and cord-blood lead (p < 0.001); placental and maternal serum, or blood, selenium (p < 0.001); and placental and maternal serum copper (p < 0.001). Maternal body mass index (BMI), maternal age, placental lead, or maternal blood lead, and smoking were retained as predictors of birth weight and BMIC in the multivariate modelling. Birth weights in both countries were normally distributed. ELEMENTS IN PLACENTA AND PREGNANCY OUTCOME IN ARCTIC AND SUBARCTIC AREAS

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Section: Original Researchsupporting

confidence: 85%

“…Iyengar and Rapp (4)(5)(6) have discussed the human placenta as a biomarker for monitoring fetal and maternal environments, with special reference to potentially toxic trace elements. In Part 1, they discuss the issues and problems of sampling of placental tissue in some detail (4).…”

Section: Original Researchmentioning

confidence: 99%

Elements in placenta and pregnancy outcome in arctic and subarctic areas

Odland

Nieboer

Romanova

et al. 2004

International Journal of Circumpolar Health

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show abstract

“…15 Therefore, the ability of the placenta to transfer nutrients and toxicants alike is of concern in relation to foetal development and health. 16 In most cases, the same processes that aid transport of nutrients through the placenta, may also act as the pathways for toxic elements, especially if these have chemical similarities with the nutrient metabolites, or simply because of passive diffusion. It is also understood that in some cases, the placenta acts as a barrier by preferentially concentrating and retaining specific toxicants, thus acting as a detoxicant and thereby reducing, to some degree, the toxic effect on the foetus.…”

Section: Introductionmentioning

confidence: 99%

The placenta as a barrier for toxic and essential elements in paired maternal and cord blood samples of South African delivering women

et al. 2009

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“…Con respecto al contenido de Pb en la placenta, Iyengar y Rapp (10,20,21) , indican que la placenta se expone a diferentes sustancias dañinas y en el caso de metales tóxicos, el tejido placentario puede ser un biomarcador dual, para evaluar la salud materna y fetal. El rango promedio de las concentraciones de Pb que determinaron en diferentes trabajos realizados en zonas de baja contaminación fue de 5-60 ng/g; observándose que la placenta parece ser una barrera débil para el Pb.…”

Section: Artículo Originalunclassified

“…Previo al trabajo de parto se muestreó 10 mL de sangre materna y luego de la recepción del neonato se tomaron 10 mL de sangre del cordón umbilical con la placenta in utero. La placenta fue muestreada de acuerdo con las recomendaciones de Iyengar y Rapp (10,20,21) . Las placentas expulsadas fueron recibidas en vasijas de acero inoxidable y se colocaron sobre gasas estériles para un secado, luego fue cortada en cuatro cuadrantes y de cada una se tomó 50 gramos de muestra, teniéndose 200 g de muestra por cada placenta que luego fueron almacenadas en bolsas estériles con cierre hermético y llevadas inmediatamente a la congeladora junto con las muestras hematológicas hasta completar el número total de muestras.…”

Section: Muestras Biológicas Y Análisis Químicounclassified

Niveles de plomo en gestantes y neonatos en la ciudad de La Oroya, Perú

Castro-Bedriñana

Chirinos-Peinado

Ríos-Ríos

2014

Rev Peru Med Exp Salud Publica

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RESUMENObjetivos. Determinar los niveles de plomo (Pb) en gestantes y neonatos en la ciudad de La Oroya, Perú. Materiales y métodos. Se realizó un estudio transversal. La población estuvo conformada por gestantes residentes durante al menos dos años en la ciudad de La Oroya, cuando operaban normalmente las fundiciones de Pb, cobre y zinc. Se obtuvo muestras de sangre de la gestante antes del parto y luego del parto se tomaron muestras de placenta y sangre del cordón umbilical. El nivel de Pb de dichas muestras fue evaluado por espectrometría de absorción atómica con horno de grafito. Se determinaron regresiones cuadráticas y correlaciones de Pearson. Resultados. Se evaluó cuarenta partos normales. Los niveles promedio de Pb en la sangre materna, cordon umbilical y placenta fueron 27,4 ± 15,6 ug/dL; 19,0 ± 12,6 ug/dL y 319,0 ± 215,9 ug/100 g, respectivamente. El 67,5% de los neonatos tuvieron más de 10 ug/dL de Pb. El nivel de Pb de la sangre del cordón umbilical representó el 69,4% del nivel de Pb en sangre materna. Los coeficientes de correlación entre el Pb de la sangre materna y cordón umbilical, sangre materna y placenta, placenta y sangre del cordón umbilical fueron 0,36; 0,48 y 0,33, respectivamente. Conclusiones. Cuando funcionaba la fundición, las gestantes y recién nacidos tenían concentraciones elevadas de Pb en sangre. Las concentraciones de Pb en la placenta y cordón umbilical tuvieron una correlación moderada con el Pb de la sangre materna. El Pb de la sangre materna y cordón umbilical fue 1,5 veces más alto que los de zonas más alejadas. Palabras clave: Plomo; Mujeres embarazadas; Recién nacido; Cordón umbilical; Metalurgia (fuente: DeCS BIREME). LEAD LEVELS IN PREGNANT WOMEN AND NEWBORNS IN LA OROYA CITY, PERU ABSTRACTObjectives. To determine blood-lead (Pb) levels in pregnant women and neonates in a metallurgical city of Peru. Materials and methods. A cross-sectional study was carried out, the population of which consisted of pregnant women who had lived for at least two years in the city of La Oroya, at the time when the lead, copper and zinc foundries operated normally. A blood sample was obtained from the pregnant women before delivery and, after delivery, from the neonate's umbilical cord and placenta. Lead levels in those samples were measured by graphite furnace atomic absorption spectrophotometry. Pearson's squared regressions and correlations were determined. Results. Forty normal deliveries were studied. The average blood lead levels in the mother, umbilical cord and placenta were 27.4 ± 15.6 ug/dL; 19.0 ± 12.6 ug/dL and 319.0 ± 215.9 ug/100 g, respectively. 67.5% of the neonates registered levels higher than 10 ug/dL. Pb levels in the umbilical cord accounted for 69.4% of Pb level in maternal blood. The correlation coefficients between Pb levels in maternal blood and umbilical cord, maternal blood and placenta, and placenta and umbilical cord were 0.36; 0.48 and 0.33, respectively. Conclusions. At the time the foundry operated, pregnant women and newborns had high blood lead concentrati...

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Human placenta as a ‘dual’ biomarker for monitoring fetal and maternal environment with special reference to potentially toxic trace elements.Part 2: Essential minor, trace and other (non-essential) elements in human placenta

Cited by 50 publications

References 32 publications

Elements in placenta and pregnancy outcome in arctic and subarctic areas

Elements in placenta and pregnancy outcome in arctic and subarctic areas

The placenta as a barrier for toxic and essential elements in paired maternal and cord blood samples of South African delivering women

Niveles de plomo en gestantes y neonatos en la ciudad de La Oroya, Perú

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