Human papillomaviruses in anogenital warts in children: typing by in situ hybridisation.

Padel, A.; Venning, V A; Evans, Mark; Quantrill, A M; Fleming, K. A.

doi:10.1136/bmj.300.6738.1491

Cited by 67 publications

(40 citation statements)

References 24 publications

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“…HPV 11 and 6 are the most frequently detected HPVs in anogenital warts in children [4,39,40]. Cutaneous HPV types like HPV 2 or 3 are also detected; however, their incidence is low [39,40]. Among non-sexually abused children with anogenital warts, cutaneous types are more common in older children aged over 4 years, in those with a relative who had skin warts, and in children with skin warts in other anatomical sites [40].…”

Section: Anogenital Wartsmentioning

confidence: 97%

“…The clinical appearance of anogenital warts varies from subtle, skin-colored flat warts to moist, pink to brown lesions found particularly in the skin creases and around the vaginal and anal openings [12]. HPV 11 and 6 are the most frequently detected HPVs in anogenital warts in children [4,39,40]. Cutaneous HPV types like HPV 2 or 3 are also detected; however, their incidence is low [39,40].…”

Section: Anogenital Wartsmentioning

confidence: 99%

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Human papilloma virus (HPV) infection in children and adolescents

2008

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Human papilloma viruses (HPV) are common pathogens associated with a wide range of cutaneous and mucosal infections in childhood. Different HPV types can cause common warts, genital warts, low-grade as well as high-grade squamous intraepithelial lesions. Anogenital warts represent an issue with legal and clinical implications and evaluation of children for the possibility of sexual abuse should be considered in all cases. Recurrent respiratory papillomatosis has also been associated with HPV infection in a variety of studies. The recently introduced HPV vaccination is expected to prevent HPV-related cervical cancer in adulthood; however, HPV infection will continue to affect children.

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Section: Anogenital Wartsmentioning

confidence: 97%

Section: Anogenital Wartsmentioning

confidence: 99%

Human papilloma virus (HPV) infection in children and adolescents

2008

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“…Bunun yanında HPV 6, 11, 16'nın oral lezyonlarda bulunabileceği ve buradan inoküle olabileceği de akılda tutulmalıdır [21]. Padel ve arkadaşları [22] AGS'si bulunan 17 çocuktan siğillerin lokalize olduğu bölgeden deri biyopsisi gerçekleştirmiş, 10 unda HPV 6 ve 11, 6 sında HPV 2 ve 3 saptamışlardır. 1 tanesinde ise biyopsi sonucunu negatif bulmuşlardır.…”

Section: Discussionunclassified

Anogenital Warts in Children and Sexual Abuse

Karateke¹

2014

Ann Clin Anal Med

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ÖzetAmaç: Bu çalışmanın amacı anogenital siğili (AGS) olan çocukların anneleri ile beraber Human Papilloma Virus (HPV) genotiplemesi yapılarak cinsel istismarı belirlemektir. Gereç ve Yöntem: Çalışmaya AGS'si olan 10 çocuk, anneleri ile beraber dâhil edildi. Çocuklarda ve annelerde HPV tiplemesi yapıldı. Ayrıca anneden 'smear' örneği alındı. Cinsel istismar düşünülen 4 çocuğa cinsel istismar testi (CSA) testi uygulandı. Bulgular: AGS'si bulunan 10 çocuğun annelerinden birinde AGS saptandı. HPV tiplemesi 4 çocukta pozitif bulunurken, bu çocukların annelerinin 3'ünde HPV tiplemesi uyumlu saptandı. Bu HPV genotiplerinin 2'si tip 6, diğeri ise tip 11 idi. Bu dört çocukta cinsel istismar 2'sinde "kesin", birinde "kuvvetle muhtemel" olarak saptanırken, diğerinde ise "mümkün" olarak tespit edildi. Tartışma: AGS'si olan ve cinsel istismar düşü-nülen çocuklarda ebeveynlerin, özellikle annenin HPV tiplemesi yapılarak cinsel istismar tanısı kolaylaşabilir. Bu değerlendirmeleri yaparken profesyonel ekiple çalışılmalı, istismar düşünülen vakalarda çocuğun daha fazla zarar gör-mesi engellenmeye çalışılmalıdır. Öte yandan anogenital siğillerin farklı bulaş yolları da olabileceğinden, tam değerlendirme yapmadan suçsuz bir aileyi zan altında bırakabilecek davranışlardan kaçınılmalıdır. Anahtar KelimelerAnogenital Siğil; Cinsel İstismar; Çocuk Abstract Aim: The aim of this study was to determine the sexual abuse in children with anogenital warts (AGW) together with their mothers by testing Human Papilloma Virus (HPV) typing. Material and Method: A total of 10 children with their mothers were included. HPV typing was performed in children and their mothers. Smear sample was taken from mothers. Child sexual abuse test was performed for 4 children in whom sexual abuse was suspected. Results: AGW was found in one of the mothers of 10 children with AGW. While HPV typing was positive in 4 children, 3 mothers was detected as "compatible" with HPV typing of their children. Two of those were type 6 and the remaining was type 11. While sexual abuse was identified to be "definite" in 2 children and "probable" in 1 child. Other was identified as "possible". Discussion: The diagnosis of sexual abuse in children with AGW and suspected sexual abuse can be facilitated by performing HPV typing in mothers of children. This requires professional teamwork to prevent any possible harm against the potential child victim of suspected sexual abuse. As other transmission routes of AGW are possible, accusing falsely innocent family before comprehensive examination should be avoided.

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“…This finding, in conjunction with epidemiological evidence, indicates that human papilloma virus types 6 and I1 are likely sexually transmitted. It has been suggested then that anogenital warts in a child may also be sexually transmitted and thus provide grounds for suspecting sexual abuse [6].…”

Section: Discussionmentioning

confidence: 99%

“…Although the type of Human Papilloma Virus (HPV) present may give some indication of the likely mode of transmission, this can be interpreted only in conjunction with all available clinical and social information. The type of virus does not provide proof of the presence or the absence of sexual transmission [6].…”

Section: Introductionmentioning

confidence: 99%