Human papilloma virus (HPV) infection in children and adolescents

Abstract

Human papilloma viruses (HPV) are common pathogens associated with a wide range of cutaneous and mucosal infections in childhood. Different HPV types can cause common warts, genital warts, low-grade as well as high-grade squamous intraepithelial lesions. Anogenital warts represent an issue with legal and clinical implications and evaluation of children for the possibility of sexual abuse should be considered in all cases. Recurrent respiratory papillomatosis has also been associated with HPV infection in a variety of studies. The recently introduced HPV vaccination is expected to prevent HPV-related cervical cancer in adulthood; however, HPV infection will continue to affect children.

Conjunctival Papilloma

“…Papillomatosis in other sites of the body show a female predominance for genital (33% vs 67%) and cutaneous (49% vs 51%) papillomas and a male predominance for upper respiratory involvement (77% vs 23%). 24,[26][27][28] Multicentric conjunctival papillomas were more common in children and adolescents than in adults, and the numerous lesions coalesced to form massive papillomatosis in 1 patient ( Figure 1B). Ash 17 studied 245 conjunctival papillomas in patients of all ages (range, 1-97 years) and found that the most common location of conjunctival papilloma was the bulbar conjunctiva (42%).…”

High-risk hpv infection in sexually active and non active young women

“…The possibility of hand transmission is suggested by the reports of children with anogenital warts who were considered to have acquired their infection from close family members or by their own hand warts. But this study applies to the cases with warts caused by low-risk HPV infection [20,21].…”

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

“…Nearly thirty years ago, Gissmann and colleagues were the first team to detect DNA sequences from HPV types 6 and 11 in laryngeal papillomas (Gissmann et al, 1983). Laryngeal papillomatosis, also known as recurrent respiratory papillomatosis (RRP), is characterized by the recurrent growth of exophytic, wart-like lesions called papillomas, along the epithelium of the upper respiratory tract, such as the vocal cords, the arytenoids, the subglottis, the trachea and most commonly, the larynx (Lacey et al, 2006;Mammas et al, 2009). Although the RRPs are benign, their recurrent nature and location in the airways require frequent surgical removal and can cause significant morbidity and occasional mortality secondary to airway obstruction.…”