Human papillomavirus vaccine and systemic lupus erythematosus

Abstract

To investigate the association between human papillomavirus (HPV) vaccination and autoimmune manifestations compatible with systemic lupus erythematosus (SLE) or SLE-like disease, the medical history of six women who presented with SLE or SLE-like disease following HPV immunization was collected. Data regarding type of vaccine, number of immunization, family and personal, clinical and serological features, as well as response to treatments were analyzed. In the reported cases, several common features were observed, such as personal or familial susceptibility to autoimmunity or adverse response to a prior dose of the vaccine, both of which may be associated with a higher risk of post-vaccination autoimmunity. Favorable response to immunosuppressant was observed in all patients. In the current study, a temporal association between immunization with HPV vaccine and the appearance of a spectrum of SLE-like conditions is reported. Additionally, among the patients described, several common features were observed that may enable better identification of subjects at risk. Further studies are required to assess the safety of immunization with the HPV vaccine in patients with autoimmune-rheumatic diseases or in subject at risk of autoimmunity as well as the potential beneficial effect of preventive immunosuppressants.

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

“…The major remitting patients with immunosuppression therapy had mild adverse effects to the vaccine immediately following the first dose of the HPV vaccine and then developed heavier SLE symptoms within two months after subsequent vaccine administration. In conclusion, the authors hypothesized a potential causal link between HPV vaccination and onset or relapse of SLE [130]. Thus, although for most patients, the benefits of immunization outweigh its risks, clinicians must be aware of the odds for an autoimmune disease onset or exacerbation following HPV vaccination.…”

“…In 2013, Gatto and coworkers investigated cases of SLE in women following HPV vaccination [130]. The onset of SLE occurred during the later doses of the HPV vaccination schedule and all the women had family histories of autoimmune disease.…”

How Silencing of Dissent in Science Impacts Woman. The Gardasil® Story

“…By 2005 the media and Wall Street questioned the company's ability to survive, however reports of the company's' emanate death were premature [47]. [58], and the "mother" of the autoimmune diseases, SLE [57]. A recent advisory issued by the American College of Pediatricians warned of the potential of premature ovarian failure (POF) in young girls, with its significant consequences for future health and prospects of motherhood [59].…”

Management of infection in systemic lupus erythematosus

“…It may therefore be worth considering the use of the quadrivalent HPV vaccination, Gardasil [61]. Mok et al reported the Gardasil vaccine to be safe and reasonably effective in a group of 50 SLE patients [62].…”