Human papillomavirus type-distribution in the cervix of Chinese women: a meta-analysis

Abstract

The aim of the study was to determine human papillomavirus (HPV) type-distribution in the cervix of Chinese women, and to estimate the potential future impact of HPV prophylactic vaccines for cervical cancer prevention in China. A total of 32 studies using polymerase chain reaction for HPV detection were included in the meta-analysis, including 2844 invasive cervical cancer (ICC), 820 high-grade squamous intraepithelial lesions (HSIL), 432 low-grade squamous intraepithelial lesions (LSIL) and 2902 women with normal cytology/histology. The overall and type-specific HPV prevalence of 18 HPV types (HPV 6, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 70, 73 and 82 of different cervical stages) were estimated. Overall HPV prevalence was 83.7%, 66.2%, 61.3% and 11.2% in ICC, HSIL, LSIL and normal, respectively. HPV 16 was the predominant type in all cervical stages. Estimated HPV 16/18 positive fractions in ICC, HSIL, LSIL and normal were 69.7%, 45.5%, 32.23% and 4.6%, respectively. HPV-16/18 vaccine has the 69.7% potential prevention in ICC. HPV 58 and 52 were the priority HPV types in Chinese women.

Human Papillomavirus (HPV) Infection in Women Participating in Cervical Cancer Screening from 2006 to 2010 in Shenzhen City, South China

“…Among single HPV subtype infections, HPV16, HPV58, HPV33, HPV43 and HPV52 were the common types. HPV52 were the predominant in the present study, which was consistent with the domestic reports (Bao et al, 2007;Liu et al, 2007;Wu et al, 2013). HPV52 undoubtedly has great significance for the new generation of vaccine development, application and cervical cancer prevention and control.…”

Human papillomavirus infection in Beijing, People's Republic of China: a population-based study

“…HPV 16,18,58,33,52 and 45 were commoner in Asia than in other areas (Bao et al, 2008b). The predominance of HPV 58 and HPV 33 in Beijing is in accordance with the results of certain surveys in other regions of China Li et al, 2006;Bao et al, 2008a).…”

Human Papillomavirus Genotypes Associated with Mucopurulent Cervicitis and Cervical Cancer in Hangzhou, China

“…The prevalence and distribution of oncogenic genotypes were also determined in 77 CC specimens. The overall prevalence of HPV infection in the CC group (84.4%) was similar to the rate of 85.9% reported in a meta-analysis of CC in Asia (Bao et al, 2008b). Like other regions worldwide, HPV16 was the predominant type (55.8%, 43/77) identified among CC patients in the present study; very similar to the previously reported rate in a meta-analysis of HPV in mainland China and Hong Kong (58.7%) (Bao et al, 2008a), but it was significantly lower than the rate found in Changchun, China (87.7%, 57/65) (Liu et al, 2013).…”