Human papillomavirus infection in Beijing, People's Republic of China: a population-based study

Zhao, Rong; Zhang, W Y; Wu, Minghui; Zhang, S W; Pan, Jing; Zhu, Lina; Zhang, Y P; Li, H; Gu, Ying; Liu, X Z

doi:10.1038/sj.bjc.6605351

Cited by 70 publications

(95 citation statements)

References 33 publications

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“…The overall prevalence of HPV infection was 10.19%, which was higher than the reported HPV prevalences of 8.3% (494/5936) in Qujing in Yunnan Province, Southwest China [10], and 6.7% in Beijing, China [13]. In studies conducted in developing countries, the prevalence of HR-HPV infection was 9.0% in a population-based study conducted in Ho Chi Minh City, Vietnam [14], and in urban Tunis, the most frequent HPV type among women 18-69 years of age was HPV-16 (3.27%) [15], which was far higher than the prevalence of HPV-16 infection in Hetian (0.3%).…”

Section: Discussioncontrasting

confidence: 56%

Prevalence of and risk factors for high-risk human papillomavirus infection: a population-based study from Hetian, Xinjiang, China

Niyazi¹,

Husaiyin²,

Han³

et al. 2015

Bosn J of Basic Med Sci

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Human papillomavirus (HPV) infection contributes to most cases of cervical cancer, and HPV genotypes exhibit different distributions according to geographic region. This study evaluates the prevalence of HPV infection in Hetian Prefecture, Xinjiang, and establishes risk factors associated with high-risk HPV (HR-HPV) genotypes in this region. In this cross-sectional, population-based study, 883 healthy women 15-54 years of age were enrolled. All participants completed a questionnaire regarding sociocultural and sexual activity characteristics. Visual inspections with acetic acid, colposcopies and biopsies were performed using the Preventive Oncology International microbiopsy protocol for pathological diagnosis. Cervical epithelial tissue specimens were collected and tested for HPV using linear array assays. According to the results of HR-HPV infection status, individuals infected with HR-HPV were classified into one group, and the remaining individuals were classified into the control group. The risk factors for HR-HPF infection were analyzed. The participants included 66 women (7.47%) with HR-HPV, 10 women (1.13%) with low-risk HPV, and 14 women (1.59%) with HPV of unknown risk. The five most prevalent types of HR-HPV were HPV-16 (0.31%), HPV-51 (0.08%), HPV-31 (0.07%), HPV-58 (0.07%), and HPV-39 (0.06%). Vulvovaginal ulcers and vulvovaginal inflammation were found in 190 participants (21.52%) and 256 participants (28.99%), respectively. The HR-HPV and control groups significantly differed with respect to age at first marriage, number of marriages, and the presence of vulvovaginal ulcers and vulvovaginal inflammation (p<0.05). Based on this study, an immunization strategy targeting HPV-16 should be prioritized in Hetian Prefecture. These findings contribute to the understanding of HPV infection.

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Section: Discussioncontrasting

confidence: 56%

Prevalence of and risk factors for high-risk human papillomavirus infection: a population-based study from Hetian, Xinjiang, China

Niyazi¹,

Husaiyin²,

Han³

et al. 2015

Bosn J of Basic Med Sci

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“…Few population-based studies exist describing the epidemiology of HPV and cervical cancer among Chinese women younger than 25 years old as well as their knowledge of HPV and attitudes towards HPV vaccination [7][8][9][10][11][12][13] . Our study bridged this gap, demonstrating the high cervical cancer disease burden of sampled Chinese women aged 18-25.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple large population-based studies have been published about HPV, CIN, and cervical cancer prevalence in China that indicated the HPV prevalence ranges from 6% in Beijing [13] to 18-23 percent in Shanxi province [7][8] . However, these studies focused on women aged 35 to 50, and those that included women younger than 25 years generally categorize them as a subgroup with sample size ranged from 40 to 56 [9][10][11] .…”

Section: Discussionmentioning

confidence: 99%

“…Multiple studies have demonstrated that the prevalence of CIN and HPV infection varies by age [4][5][6] . Though several population-based screening studies reported the prevalence of HPV infection and CIN in China [7][8][9][10][11][12][13] , most studies focused on women older than 30 or 35. Very few data exist describing HPV and CIN prevalence among Chinese women younger than 25 years old.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of HPV infection and cervical intraepithelial neoplasia and attitudes towards HPV vaccination among Chinese women aged 18–25 in Jiangsu Province

Hong

Zhao

et al. 2011

Chin. J. Cancer Res.

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Objective: Few data are available on the epidemiology of HPV and cervical cancer among Chinese women younger than 25 years old. This study aimed to estimate the HPV infection rate and the prevalence of cervical intraepithelial neoplasia (CIN) in women aged 18-25, as well as their knowledge of and attitudes towards HPV vaccination.Methods: A population-based cervical cancer screening study was conducted on women aged 18-25 in Jiangsu province in 2008. Participants provided socio-demographic, reproductive and behavioral information and completed a survey about their knowledge of and attitudes towards HPV vaccination. Women then underwent a gynecologic exam to provide two cervical exfoliated cell samples for high risk HPV DNA testing and liquid-based cytology (LBC) as well as visual inspection with acetic acid (VIA). Women testing positive for any test were referred to colposcopy and biopsy. The gold standard for diagnosis of cervical lesions was directed or random biopsies.Results: Within the sample of 316 women, 3.4% of them were diagnosed with CIN grade 2 or worse lesions and 17.1% were found to be positive for HPV DNA. Among these young women, extra-marital sexual behavior of them (OR=2.0, 95%CI: 1.1-3.8) or their husbands (OR=2.6, 95%: 1.4-4.7) were associated with an increased risk of HPV positivity. Although overall HPV awareness was low, after a brief educational intervention, 98.4% reported they would electively receive HPV vaccination and would also recommend that their daughters be vaccinated. However, most urban and rural women reported their ideal maximum out-of-pocket contribution for HPV vaccination to be less than 500 RMB and 50-100 RMB, respectively. Conclusion: Our study indicates cervical disease burden is relatively high among sampled Chinese women aged 18-25. Appropriate educational interventions for female adolescents and strategies to subsidize vaccine costs are definitely needed to ensure the effectiveness of vaccination campaigns in China.

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“…18 Similar findings were reported in Korea and China, where HPV33, À52 and À58 are more common. 18,21,22 Therefore, we did not genotype for HPV45, and the present study is limited by a lack of data on HPV45. Another potential limitation of this study is that the study population did not include women with normal cytology.…”

Section: Infectious Causes Of Cancermentioning

confidence: 99%

Incidence risk of cervical intraepithelial neoplasia 3 or more severe lesions is a function of human papillomavirus genotypes and severity of cytological and histological abnormalities in adult Japanese women

Hosaka

Fujita

Hanley

et al. 2012

Intl Journal of Cancer

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We examined incidence probabilities of cervical intraepithelial neoplasia 3 (CIN3) or more severe lesions (CIN3+) in 1,467 adult Japanese women with abnormal cytology in relation to seven common human papillomavirus (HPV) infections (16/18/31/33/35/52/58) between April 2000 and March 2008. Sixty‐seven patients with multiple HPV infection were excluded from the risk factor analysis. Incidence of CIN3+ in 1,400 patients including 68 with ASCUS, 969 with low grade squamous intraepithelial lesion (LSIL), 132 with HSIL without histology‐proven CIN2 (HSIL/CIN2(−)) and 231 with HSIL with histology‐proven CIN2 (HSIL/CIN2(+)) was investigated. In both high grade squamous intraepithelial lesion (HSIL)/CIN2(−) and HSIL/CIN2(+), HPV16/18/33 was associated with a significantly earlier and higher incidence of CIN3+ than HPV31/35/52/58 (p = 0.049 and p = 0.0060, respectively). This association was also observed in LSIL (p = 0.0002). The 1‐year cumulative incidence rate (CIR) of CIN3+ in HSIL/CIN2(−) and HSIL/CIN2(+) according to HPV genotypes (16/18/33 vs. 31/35/52/58) were 27.1% vs. 7.5% and 46.6% vs. 19.2%, respectively. In contrast, progression of HSIL/CIN2(+) to CIN3+ was infrequent when HPV DNA was undetected: 0% of 1‐year CIR and 8.1% of 5‐year CIR. All cervical cancer occurred in HSIL cases of seven high‐risk HPVs (11/198) but not in cases of other HPV or undetectable/negative‐HPV (0/165) (p = 0.0013). In conclusion, incidence of CIN3+ depends on HPV genotypes, severity of cytological abnormalities and histology of CIN2. HSIL/CIN2(+) associated with HPV16/18/33 may justify early therapeutic intervention, while HSIL/CIN2(−) harboring these HPV genotypes needs close observation to detect incidence of CIN3+. A therapeutic intervention is not indicated for CIN2 without HPV DNA.

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Human papillomavirus infection in Beijing, People's Republic of China: a population-based study

Cited by 70 publications

References 33 publications

Prevalence of and risk factors for high-risk human papillomavirus infection: a population-based study from Hetian, Xinjiang, China

Prevalence of and risk factors for high-risk human papillomavirus infection: a population-based study from Hetian, Xinjiang, China

Prevalence of HPV infection and cervical intraepithelial neoplasia and attitudes towards HPV vaccination among Chinese women aged 18–25 in Jiangsu Province

Incidence risk of cervical intraepithelial neoplasia 3 or more severe lesions is a function of human papillomavirus genotypes and severity of cytological and histological abnormalities in adult Japanese women

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