Human Papillomavirus Type 16 Intratypic Variant Infection and Risk for Cervical Neoplasia in Southern China

Chan, Paul K.S.; Lam, Ching Wan; Cheung, Tak Hong; Li, William W. H.; Lo, Kwok-Tung; Chan, Michael C. W.; Cheung, Jo L.K.; Li, Xu; Cheng, A. F. B.

doi:10.1086/342048

Cited by 59 publications

(72 citation statements)

References 13 publications

(17 reference statements)

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“…Data from east China (Zhejiang) belonged to the second group (20). Data from Hong Kong (southern China) also conformed to the second group, which belonged to a population-based study (6). However, the distributions of the European prototype and European variants in northeast China were specific, because the data were different from data of any other area by statistical analysis.…”

Section: Discussionmentioning

confidence: 82%

“…Based on our results, it was supposed that genetic movement of D25E mutations might exist in these neighboring areas, for northeast China lies geographically between high-frequency areas (central and southern China and southeast Asia) and low-distribution areas (Russia and Mongolia). T178A, which led to D25E amino acid changes, was found in the Chinese and Japanese populations (5,6,47). The L83V distribution was lower in the Asian population and higher in the American and European populations.…”

Section: Discussionmentioning

confidence: 93%

“…Since HPV 16 variants are associated with geographic diversity and oncogenic risk, we analyzed the data with China origin (southwest China, central China, and southern China) and those from neighboring countries (Russia and Japan) (52). Hong Kong, Mongolia, and Korea were excluded from the analysis since no individual data on cervical carcinoma samples were reported (6,8,9).…”

Section: Discussionmentioning

confidence: 99%

“…D25E and L83V are associated with the elevated risk of cervical carcinomas and vary geographically due to genetic differences between populations (1,3,18,22,25,27,54,55). The D25E variant distributes mainly in Asian populations rather than in Russia (0%) (6,28,31,52). Based on our results, it was supposed that genetic movement of D25E mutations might exist in these neighboring areas, for northeast China lies geographically between high-frequency areas (central and southern China and southeast Asia) and low-distribution areas (Russia and Mongolia).…”

Section: Discussionmentioning

confidence: 99%

“…The Asian lineage was reported in southwest China (31.0% in Sichuan) and southern China (50.6% in Hong Kong). The European prototype was reported in southwest China (23.0% in Sichuan), central China (15.52% in Hubei), and southern China (30.0% in Hong Kong) (5,6,35). No data on HPV 16 variants and sequence variations were reported in northern China and northeast China.…”

mentioning

confidence: 99%

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Human Papillomavirus Type 16 Variant Analysis of E6, E7, and L1 Genes and Long Control Region in Identification of Cervical Carcinomas in Patients in Northeast China

et al. 2011

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Human papillomavirus type 16 (HPV 16) is the primary etiology of cervical cancer, which is the second most common type of cancer in women worldwide (29). HPV 16 variants, which vary by Յ2% from HPV 16 prototype nucleotide sequences, have been identified as the following six phylogenetic branches: European (E), Asian (As), Asian-American (AA), African-1 (Af-1), African-2 (Af-2), and northern American (NA) variants (18,52). Several researchers had reported correlations between specific HPV 16 variants and persistent viral infection, followed by the development of malignant lesions (3,4,16,37,43,49,50). Non-European variants were found to be associated with an excess risk of cervical cancer (37). These variants had been found to show different geographic distributions, while some sequence variations had oncogenic potentials. In HPV 16 variants, the L83V mutation in E6 in the Swedish and Italian populations and D25E in E6 in the Japanese population were reported to be associated with the

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Human Papillomavirus Type 16 Variant Analysis of E6, E7, and L1 Genes and Long Control Region in Identification of Cervical Carcinomas in Patients in Northeast China

et al. 2011

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Epidemiologic and viral factors associated with cervical neoplasia in HPV‐16‐positive women

Rajeevan

Swan

Nisenbaum

et al. 2005

Intl Journal of Cancer

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While infection with high-risk HPV is the most important risk factor for cervical cancer, HPV alone is insufficient. Our purpose was to identify viral and epidemiologic factors associated with cervical disease in HPV-16 DNA-positive women referred to colposcopy. We used a standardized interview to collect epidemiologic data from consenting women. Total nucleic acids from exfoliated cervical cells were used for all viral assays (HPV detection and typing using L1 consensus PCR with line probe hybridization, variant classification by sequencing, viral load and transcript copy determination by quantitative PCR and transcript pattern by nested RT-PCR). Cervical disease was based on colposcopic biopsy. Logistic regression was used to calculate ORs with 95% CIs. There were 115 HPV-16 positive women among 839 enrollees. By univariate analyses, age >25 years (OR = 3.05, 95% CI 1.20-7.76), smoking (OR = 3.0, 95% CI 1.19-7.56), high viral load (OR = 5.27, 95% CI 2.05-13.60), detection of both E6 and E6*I transcripts (OR = 10.0, 95% CI 2.1-47.58) and high transcript copies (OR = 5.56, 95% CI 2.05-13.60) were significant risk factors for CIN III with reference to No CIN/CIN I. Less than a third of the women (31.5%) had prototype HPV-16 detected, and variants showed no association with disease, viral load or transcription. Viral DNA and transcript copies were highly correlated, and the ratio of transcript copies to DNA copies was not changed with disease status. While viral load, transcript copies and transcript pattern were statistically associated with CIN III, none of these measures effectively discriminated between HPV-16 women with disease requiring treatment and those who could be followed. Cellular proliferation and differentiation pathways affected by HPV should be investigated as biomarkers for cervical cancer screening. ' 2005 Wiley-Liss, Inc.Key words: HPV-16 E6/E7 transcripts; biomarker; cervical neoplasia; screening; exfoliated cervical cells High-risk HPV types are recognized as carcinogenic agents, 1 and infection with high-risk HPV is the most important risk factor for cervical cancer. However, it is clear that HPV alone is insufficient to cause cancer. Most HPV infections are transient and associated with no lesions or spontaneously regressing low-grade precancerous lesions. Factors that facilitate HPV oncogenesis are important targets for early detection, therapeutic intervention and monitoring the response to therapy. Identifying these factors may be difficult because of the high baseline risk associated with HPV infection. One approach is to identify risk factors for cervical disease in groups with high-risk HPV infection.Our purpose was to examine viral and epidemiologic factors associated with biopsy-confirmed cervical disease in HPV-16 DNA-positive women referred to colposcopy. Viral characteristics other than simple HPV type may be associated with disease and reflect increased virulence or increased host susceptibility. We examined the genotype variants of HPV-16, HPV DNA copy number (viral load), patt...

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HLA-B alleles, high-risk HPV infection and risk for cervical neoplasia in southern Chinese women

Chan

Cheung

et al. 2005

Int. J. Cancer

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A population-based study was conducted on 256 southern Chinese with cervical intraepithelial neoplasia grade III (CIN III) or invasive cervical cancer (ICC) and on 258 controls to examine the associations between HLA-B alleles, infection with high-risk human papillomaviruses (HPVs) and the development of cervical neoplasia. HLA-B15 was found to be protective for CIN III/ICC overall (p corrected 5 0.003), and for HPV52-positive CIN III/ICC (p corrected 5 0.003). A marginal protective effect of B15 was observed for HPV16-positive CIN III/ICC, but no significant associations were revealed for HPV18-or HPV58-positive cases. None of the HLA-B alleles were found to confer an increased risk for cervical neoplasia. HLA-B15 is common among Asian for whom HPV52, a worldwide uncommon HPV type, also exists in a relatively high prevalence. It would also be worthwhile to assess the association between HLA-B15, HPV52 and cervical cancer in other Asian populations. ' 2005 Wiley-Liss, Inc.Key words: HLA; Chinese; HPV; cervical cancer; host genetics Infection with high-risk human papillomaviruses (HPVs) is necessary for the development of cervical cancer.1 However, HPV infection alone is not sufficient and most HPV infections regress spontaneously. For cases that do progress to cancer, a long period of latency is usually required. It has become evident that a combination of environmental, viral and host factors interplay to influence the malignant progression.2 The human leukocyte antigen (HLA) system is involved in presenting foreign antigens to immune cells. This family of molecules is divided into 2 major classes. The class I molecules including A, B and C are expressed in most nucleated cells and are essential for targeting infected cells for killing by cytotoxic T-cells. HLA polymorphism results in variation of the peptide binding cleft that influences the immune response to pathogens. Certain HLA alleles have shown to be associated with an increased or decreased risk for cervical cancer among different ethnic populations. 4 Although cervical cancer remains an important cause of death in most parts of China, so far little is known on its association with HLA alleles. The objective of our study was to assess the association between HLA alleles and high-risk HPV infections on the risk of development of cervical neoplasia in southern Chinese. Our study focused on the HLA class I B alleles, as most previous studies have been on class II alleles. Material and methods Case subjectsA population-based study was performed to compare the frequency of HLA-B alleles between Hong Kong Chinese women with cervical neoplasia and controls. Women attending the Gynaecology Clinic at the Prince of Wales Hospital with biopsy-confirmed cervical intraepithelial neoplasia (CIN) III or invasive cervical carcinoma (ICC) were recruited. Peripheral blood samples and cervical scrape/biopsy samples were collected from participants with a written informed consent. Women with surnames that appeared to be non-Chinese were excluded from the study. The study...

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Human Papillomavirus Type 16 Intratypic Variant Infection and Risk for Cervical Neoplasia in Southern China

Cited by 59 publications

References 13 publications

Human Papillomavirus Type 16 Variant Analysis of E6, E7, and L1 Genes and Long Control Region in Identification of Cervical Carcinomas in Patients in Northeast China

Human Papillomavirus Type 16 Variant Analysis of E6, E7, and L1 Genes and Long Control Region in Identification of Cervical Carcinomas in Patients in Northeast China

Epidemiologic and viral factors associated with cervical neoplasia in HPV‐16‐positive women

HLA-B alleles, high-risk HPV infection and risk for cervical neoplasia in southern Chinese women

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