1986
DOI: 10.1016/s0140-6736(86)91965-3
|View full text |Cite
|
Sign up to set email alerts
|

Human Papillomavirus Type-16 Homologous Dna in Normal Human Ectocervix

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

1
28
0

Year Published

1987
1987
2010
2010

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 72 publications
(29 citation statements)
references
References 4 publications
1
28
0
Order By: Relevance
“…In some papers which do, the subjects come from a limited number of clinics or hospitals, but it is still not clear whether any further selection has taken place (Cox et al, 1986;Lorincz et al, 1986;Macnab et al, 1986;Meanwell et al, 1987;Schneider et al, 1987;Scholl et al, 1985;Wagner et al, 1984;Wickenden et al, 1985). Information on the source of cases is important in the choice of the control group.…”
Section: Hpv Prevalence Surveysmentioning
confidence: 99%
See 1 more Smart Citation
“…In some papers which do, the subjects come from a limited number of clinics or hospitals, but it is still not clear whether any further selection has taken place (Cox et al, 1986;Lorincz et al, 1986;Macnab et al, 1986;Meanwell et al, 1987;Schneider et al, 1987;Scholl et al, 1985;Wagner et al, 1984;Wickenden et al, 1985). Information on the source of cases is important in the choice of the control group.…”
Section: Hpv Prevalence Surveysmentioning
confidence: 99%
“…Some doubt has recently been cast on the role of the virus in cervix cancer by reports of high prevalence of HPV 16 and 18 in normal cervical tissue (Cox et al, 1986;Macnab et al, 1986;Meanwell et al, 1987;Reeves et al, 1987;, and the possibility that the apparent association with cervical neoplasia disappears after age-adjustment (Meanwell et al, 1987). In the light of the continuing debate about the importance of HPV infection in the aetiology of cervical cancer (Editorial, 1987a,b;Mufioz & Bosch, 1987) and confronted by practical problems in the design of our own epidemiological study, we decided to critically evaluate the available epidemiological evidence, which consists of prevalence surveys of HPV in various population groups, and some cohort studies of women with cervical HPV infection or low-grade dysplasia.…”
mentioning
confidence: 99%
“…However, both HPV-16 and HPV-18 can be detected in women with undetectable or minimal cervical abnormality (3,4), and it is unclear what factors trigger HPV-16 or HPV-18 to initiate cellular transformation to a malignant phenotype.…”
Section: Introductionmentioning
confidence: 99%
“…These viruses produce oncogenic proteins E6 and E7 which are capable of transforming cells to a malignant phenotype and it is now generally accepted that the production of these proteins by HPV-16 or HPV-18 results in cervical cancer. However, infection with both HPV-16 and HPV-18 can be detected in women with no cervical abnormality (Burghardt, 1984;Cox et al, 1986). Moreover, most infections with HPV-16 or HPV-18 in young women are of short duration with median clearance times of approximately 1 year with long term persistence of the virus being associated with signi®cant risk of progression to cancerous lesions such as cervical intraepithelial neoplasia type 3 (CIN3) (Nobbenhuis et al, 1999).…”
mentioning
confidence: 99%