Human papillomavirus is detected in transitional cell carcinoma arising in renal transplant recipients

Husain, Ehab; Prowse, David M.; Ktori, Elena; Shaikh, Taufiq; Yaqoob, Magdi; Junaid, Islam; Baithun, Suhail

doi:10.1080/00313020902756303

Cited by 21 publications

(8 citation statements)

References 25 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25 HPV has also been associated with urothelial carcinoma in renal transplant recipients. 26 Considering these findings, it appears that any link between HPV and bladder neoplasia is more directly associated with particular clinical circumstances than as a general etiologic agent in the majority of bladder cancers.…”

Section: Discussionmentioning

confidence: 96%

Human Papillomavirus is Not an Etiologic Agent of Urothelial Inverted Papillomas

Alexander

Davidson

López-Beltrán

et al. 2013

American Journal of Surgical Pathology

View full text Add to dashboard Cite

Inverted papilloma of the urinary bladder is rare, accounting for <1% of all bladder neoplasms. Although there is general consensus that inverted papilloma is benign in nature, little is known about its pathogenesis. Some have suggested that human papillomavirus (HPV) plays an etiologic role in the development of this neoplasm. These claims have not been adequately substantiated, and there is controversy as to the role of HPV in other urinary bladder neoplasms as well. To further investigate a possible etiologic role of HPV in urothelial neoplasia, we evaluated 27 inverted papillomas of the urinary bladder for the presence of HPV. Both immunohistochemical and in situ hybridization (ISH) studies for HPV and immunohistochemical analysis for p16, a surrogate marker for HPV infection, were used to assess HPV infection status. In the urinary bladder inverted papillomas of these 27 patients (age range, 35 to 78 y; M:F ratio, 11:1), no HPV was detected by HPV immunohistochemistry or by ISH. Immunoreactivity to p16 was detected in 11/27 (41%) of the cases. Expression of p16 is seen inconsistently within these neoplasms and does not correlate with the presence of HPV antigens or genes by immunohistochemistry or ISH, respectively. Therefore, p16 is not a reliable surrogate marker for HPV infection in urothelial inverted papilloma. Our findings indicate the absence of HPV in urothelial inverted papillomas. HPV testing should not be used as a diagnostic adjunct for inverted papilloma cases.

show abstract

Section: Discussionmentioning

confidence: 96%

Human Papillomavirus is Not an Etiologic Agent of Urothelial Inverted Papillomas

Alexander

Davidson

López-Beltrán

et al. 2013

American Journal of Surgical Pathology

View full text Add to dashboard Cite

show abstract

“…These findings are compatible with those of Gould [10] and Alexander [9], who found no evidence of HPV infection in a combined 45 cases of IUP. Evidence has emerged showing that HPV infection is not a driving event in the carcinogenesis of UCA [30–33], except in rare circumstances like basaloid squamous cell carcinomas arising in neurogenic bladders [34] or upper tract tumors arising in kidney transplant recipients [35]. Likewise, our investigation of the HPV status of inverted UCA, both high grade and low grade, shows no presence of HPV DNA either by ISH or PCR (Table 1 and Figure 1).…”

Section: Discussionmentioning

confidence: 99%

HRAS mutations are frequent in inverted urothelial neoplasms

McDaniel¹,

Zhai²,

Cho³

et al. 2014

Human Pathology

View full text Add to dashboard Cite

Inverted urothelial papilloma (IUP) is an uncommon neoplasm of the urinary bladder with distinct morphological features. Studies regarding the role of human papillomavirus (HPV) in the etiology of IUP have provided conflicting evidence of HPV infection. Additionally, little is known regarding the molecular alterations present in IUP or other urothelial neoplasms which might demonstrate inverted growth pattern like low-grade or high-grade urothelial carcinoma. Here, we evaluated for the presence of common driving somatic mutations and HPV within a cohort of inverted urothelial papillomas, (n=7) non-invasive low-grade papillary urothelial carcinomas with inverted growth pattern (n=5,) and non-invasive high-grade papillary urothelial carcinomas with inverted growth pattern (n=8). HPV was not detected in any case of inverted urothelial papilloma or inverted urothelial carcinoma by either ISH or by PCR. Next generation sequencing identified recurrent mutations in HRAS (Q61R) in 3 of 5 inverted urothelial papillomas, described for the first time in this neoplasm. Additional mutations of Ras pathway members were detected including HRAS, KRAS, and BRAF. The presence of Ras pathway member mutations at a relatively high rate suggests this pathway may contribute to pathogenesis of inverted urothelial neoplasms. Additionally, we did not find any evidence supporting a role for HPV in the etiology of inverted urothelial papilloma.

show abstract

“…One of the other medical causes of BC is infection with the Human Papilloma Virus (HPV). Various studies in different parts of the world indicate the existence of an association between anogenital HPV types 16 and 18 with BC (Husain et al, 2009;Noël et al, 1994) since HPV16 and HPV18 encode E6 and E7 oncoproteins. The E6 and E7 proteins are able to bind to cellular anti-tumor factors, such as p105RB and p53, and finally by inhibiting the function of these proteins they cause permanent cell life (Li et al, 2011).…”

Section: -Medical Conditionsmentioning

confidence: 99%

Essentials of bladder cancer worldwide: incidence, mortality rate and risk factors

et al. 2017

View full text Add to dashboard Cite

Bladder cancer (BC) is the sixth most common cancer in the world. An increase in the incidence and recurrence of BC has led to massive pressure on health care systems. Studies have shown that the geographical and ethical distributions of BC are variable in different parts of the world. However, most studies have focused more on clinical challenges and treatment strategies in BC management. Due to the limited number of studies conducted on the incidence rate, mortality and risk factors of BC worldwide, it is necessary to carry out studies in these areas. Therefore, the aim of this study was to determine the global incidence rate, mortality rate and risk factors for BC.

show abstract

Human papillomavirus is detected in transitional cell carcinoma arising in renal transplant recipients

Cited by 21 publications

References 25 publications

Human Papillomavirus is Not an Etiologic Agent of Urothelial Inverted Papillomas

Human Papillomavirus is Not an Etiologic Agent of Urothelial Inverted Papillomas

HRAS mutations are frequent in inverted urothelial neoplasms

Essentials of bladder cancer worldwide: incidence, mortality rate and risk factors

Contact Info

Product

Resources

About