Human Papillomavirus Infections: Epidemiology, Pathogenesis, and Therapy

Severson, Jessica L.; Evans, Tanya; Lee, Patricia; Chan, Teh Sheng; Arany, István; Tyring, Stephen K.

doi:10.1177/120347540100500110

Cited by 46 publications

(34 citation statements)

References 201 publications

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“…Yüzey keratinizasyonuna bağlı olarak lezyonun rengi beyaz, hafif kırmızı veya normal renkte olabilir (2,5,6). OSHP lezyonları, ekzofitik karsinoma, verrüköz karsinoma veya kondiloma akuminatuma klinik görüntü açısından benzemesi nedeniyle endişe uyandırabilmekte-dir (3,7). Çoğunlukla yavaş ilerleyen bu asemptomatik lezyonların patolojik değerlendirmede benign karakterde olduğu görülmektedir (5)(6)(7)(8).…”

Section: Introductionunclassified

“…OSHP lezyonları, ekzofitik karsinoma, verrüköz karsinoma veya kondiloma akuminatuma klinik görüntü açısından benzemesi nedeniyle endişe uyandırabilmekte-dir (3,7). Çoğunlukla yavaş ilerleyen bu asemptomatik lezyonların patolojik değerlendirmede benign karakterde olduğu görülmektedir (5)(6)(7)(8). DOI: 10.5455/musbed.20150311070318 OSHP, histopatolojik incelemede keratinize çok katlı epitelin proliferasyonu sonucu fibrovasküler bağ dokusu ile birlikte parmaksı çıkıntılarla karakterizedir (5,6,8).…”

Section: Introductionunclassified

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Oral Squamous Cell Papilloma: A Case Report

Özener¹,

Kuru²,

Kuru³

2015

MUSBED

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Section: Introductionunclassified

Oral Squamous Cell Papilloma: A Case Report

Özener¹,

Kuru²,

Kuru³

2015

MUSBED

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“…Kronik enflamasyon hücresel immun yanıtı baskılamakta ve HPV kalıcılığı ihtimalini arttırmaktadır (8). Bazı yazarlar, klamidya trokomatis, herpes simpleks virus tip 2 (HSV-2) ve HIV benzeri seksüel yoldan bulaşan bir retrovirus olan insan T hücre lenfotropik virus tip 1 (HTLV-I) enfeksiyonlarının HPV için bir kofaktör olacağına dikkat çekmektedirler (12,13).…”

Section: Introductionunclassified

Kronik Vajinal Akıntılı Hastalarda HPV-DNA Pozitiflik Oranı ve Sitopatolojik Sonuçların Değerlendirilmesi

Ateşer¹,

Aydın²,

Gunver³

et al. 2014

Haseki

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Abs tractAim: There are new publications stating that chronic infection may facilitate dysplastic changes and persistence of human papillomavirus (HPV)-DNA positivity. Frequency of this coincidence and cervical cytological and pathological examination results were investigated in patients with chronic vaginal discharge. Methods: One hundred three patients, who were treated at least 3 times for chronic mucopurulent discharge with accessible HPV DNA results, were analyzed retrospectively. Risk factors were identified for HPV DNA positivity. HPV DNA positive-patients were divided into two groups (positive and negative) according to the presence and absence of HPV DNA. The results of cytopatological and histopathological examinations and risk factors were compared between the two groups. Results: The mean age of the patients was 35±9 years. Sixty-four percent of the patients were positive for HPV DNA. Of the HPV DNA positive patients, 41% had abnormal cytological findings, 16% had cervical intraepithelial neoplasia (CIN). Of the HPV DNAnegative patients, 16% had abnormal cytological findings and, 2 patients had CIN. There was no statistically significant difference in cervical cytological abnormalities and CIN between HPV-DNA positive and negative groups. Conclusion: In our study, the rates of HPV DNA positivity and abnormal cytopathological results among patients with chronic vaginal discharge were found to be higher than that reported in the literature.

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“…DNA extraction: the cervical samples were digested in a buffer containing 20 mg/mL proteinase K (20 mM (NH 4 ) 2 SO 4 , 75 mM Tris HCl [pH 8,8] 0,1% Tween 20) at 55° C for 3 hours; followed by 10 minutes at 95°C. DNA isolation was performed by phenol-chloroform extraction and ethanol precipitation.…”

Section: Methodsmentioning

confidence: 99%

“…Detection of HPV DNA, especially in latent infections, can be helpful in detecting cancer and precursor lesions. 8 This study was designed to evaluate the effect of HPV, especially type 16 in colposcopy patients, both with and without cervical pathologies and to associate it with the clinical findings in our hospital.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of human papillomavirus (HPV) and HPV-16 genotyping by real-time PCR in patients with several cervical pathologies

Dinç¹,

Rota²,

Onan³

et al. 2010

Braz J Infect Dis

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Prevalence of human papillomavirus (HPV) and HPV-16 genotyping by real-time PCR in patients with several cervical pathologies ABSTRACT Purpose: this study was planned to evaluate the prevalence of HPV (excepting type 16) and HPV 16 by real-time PCR in colposcopy patients and to interprete the results with age, age of first sexual intercourse (FSI), parity and Pap smear results. Methods: one hundred and two colposcopy patients (50 and 52 of the patients were classified as colposcopy positive and negative, respectively) applying to Gynecology clinic were included. HPV (excepting type 16) and HPV 16 were detected by realtime PCR using the L1 region. Real-time nested amplifications of MY09/11 products were done by GP5+/GP6+ primers and Cyanine-5 labeled HPV and HPV 16 DNA specific probe after HPV DNA extraction by phenol chloroform isoamylalcohol. Results: HPV (excepting type 16) and HPV 16 were positive in 12% and 18% of the colposcopy positive patients respectively. HPV (excepting type 16) and HPV 16 were positive in 5.7% and 3.8% of the colposcopy negative patients, respectively. Conclusion: there was a statistically significant difference between colposcopy positive and colposcopy negative patients comparing HPV 16 with total HPV positivity (p = 0.021 for type 16 and p = 0.010 for total HPV) but there was not a statistically significant difference between colposcopy positive and colposcopy negative patients when we compared HPV (excepting type 16) positivity (p = 0.314). In conclusion, HPV detection and typing may be helpful for cervical cancer screening and prevention.

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Human Papillomavirus Infections: Epidemiology, Pathogenesis, and Therapy

Cited by 46 publications

References 201 publications

Oral Squamous Cell Papilloma: A Case Report

Oral Squamous Cell Papilloma: A Case Report

Kronik Vajinal Akıntılı Hastalarda HPV-DNA Pozitiflik Oranı ve Sitopatolojik Sonuçların Değerlendirilmesi

Prevalence of human papillomavirus (HPV) and HPV-16 genotyping by real-time PCR in patients with several cervical pathologies

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