Human papillomavirus infections among women with cervical lesions and cervical cancer in Eastern China: genotype-specific prevalence and attribution

Zhang, Lei; Bi, Qingqing; Deng, Hua; Xu, Jing; Chen, Juan; Zhang, Meilian; Mu, Xiaojing

doi:10.1186/s12879-017-2223-1

Cited by 47 publications

(49 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study in East China shows that the HPV infection rate is 81.4% for CIN2 and 88.1% for CIN3. 20 A study in Gansu, China displayed that the HPV infection rate was 87.5% for CIN2/3. 21 These indicate that the difference in the HPV infection rate for CIN2 and 3 in different regions of China was not great.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Distribution and attribution of high-risk human papillomavirus genotypes in cervical precancerous lesions in China

Wang

Song

et al. 2017

Tumour Biol.

View full text Add to dashboard Cite

While human papillomavirus vaccine was recently approved by China Food and Drug Administration, mapping of high-risk human papillomavirus distribution and attribution in cervical precancerous lesions in China becomes critical in development of a high-risk human papillomavirus-based cervical cancer screening and prevention strategy. In total, 1016 patients with cervical precancerous lesions diagnosed in the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences were analyzed retrospectively, including 111 patients with low-grade squamous intraepithelial lesions and 905 patients with high-grade squamous intraepithelial lesions. HPV16, 58, 52, 33, and 31 were the most common high-risk human papillomavirus genotypes in order of decreasing frequency among high-risk human papillomavirus-positive high-grade squamous intraepithelial lesions; this differed from the high-risk human papillomavirus distribution in low-grade squamous intraepithelial lesions (HPV16, 52, 39, 56, and 58). The distribution of high-risk human papillomavirus genotypes in single-type infections for high-grade squamous intraepithelial lesions (HPV16, 58, 33, and 52) was similar to that in multiple-type infections (HPV16, 58, 52, and 33). By contrast, a more diverse distribution spectrum of high-risk human papillomavirus genotypes for low-grade squamous intraepithelial lesions was observed between single-type (HPV16, 52, 39, and 56) and multiple-type infection (HPV52, 68, 58, 59, 39 and 56). A previously published method was adopted to calculate the fractional proportion of individual high-risk human papillomavirus genotypes in multiple infections. For this proportional attribution, HPV16 (48.9%), 58 (10.0%), 33 (5.5%), and 52 (5.5%) were the most frequent among all high-grade squamous intraepithelial lesions, whereas HPV16 (13.2%), 52 (11.6%), 39 (9.5%), and 56 (7.6%) were the most frequent among all low-grade squamous intraepithelial lesions. Differences in high-risk human papillomavirus distribution and proportional attribution in different cervical pathology statuses (high-grade squamous intraepithelial lesions and low-grade squamous intraepithelial lesions) demonstrated the critical role of persistent infection of certain high-risk human papillomavirus such as HPV16, 58, 33, and 52 in carcinogenesis of cervical cancer. Distinctively high prevalence of HPV58, 33 and 52 in Chinese cervical intraepithelial neoplasia population, especially in high-grade squamous intraepithelial lesions, should be taken into consideration in cervical cancer screening strategy and vaccine development.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Additionally, HPV distributions for LSILs in China are different in various studies. 5,6,20 This suggests that women with LSILs usually merge with temporary HPV infections. 23 One study reported that HPV16, 18, 31, and 33 persistent infections were associated with HSILs, particularly HPV16.…”

Section: Discussionmentioning

confidence: 99%

Distribution and attribution of high-risk human papillomavirus genotypes in cervical precancerous lesions in China

Wang

Song

et al. 2017

Tumour Biol.

View full text Add to dashboard Cite

show abstract

“…Genital yolu infekte eden 40'tan fazla HPV genotipi tanımlanmıştır. Mukozal HPV tipleri servikal kanserle ilişkilerine göre, HPV [3][4][5] .…”

Section: Introductionunclassified

The Prevalence of Human Papillomavirus Genotypes in Women with Abnormal Cervical Cytology

Özen¹,

Çimentepe²,

Vardar³

et al. 2018

FLORA

View full text Add to dashboard Cite

Giriş: Human papillomavirüs (HPV) servikal kanserin majör sebebidir. Servikal kanser kadınlar arasında dünya genelinde ikinci en sık görülen kanser olmakla birlikte, gelişmekte olan ülkelerde kansere bağlı ölümlerin önemli etkenlerinden biridir. Dünyada her yıl yaklaşık 500.000 yeni servikal kanser tanımlanmakta ve bunların yarısına yakınının ölümle sonuçlandığı tahmin edilmektedir. Servikal kanser taramasında yüksek riskli HPV DNA testi ve sitolojik tarama testinin birlikte kullanılmasıyla servikal prekanseröz lezyonların erken tanısı ve tedavisi sonucu servikal kanser büyük oranda önlenebilir bir hastalıktır. Servikal kansere karşı primer koruma sağlayan profilaktik HPV aşılarının 2006 yılından itibaren uygulanmaya başlanmasıyla servikal kanser sıklığı ve mortalitenin azalması amaçlanmıştır. HPV aşısının, yüksek risk (HR) HPV tiplerine karşı immünite gelişmesini sağlayarak prekanseröz lezyonlara karşı korunmada etkin olduğu ispatlanmış ve bu aşı birçok ülkede rutin aşı programına dahil edilmiştir. Bu çalışmada, anormal servikal sitolojili kadınlarda gerçek zamanlı polimeraz zincir reaksiyonu (PCR) testi kullanılarak HPV prevalansı ve genotiplerinin tespiti amaçlanmıştır.

show abstract

“…Our group analyzed HPV infections in patients with cervical cancer or precancerous cervical lesions and found that 90.8% of cervical cancer patients were infected with high‐risk HPVs, and the 5 subtypes of high‐risk HPV with the highest infection rate were 16, 18, 58, 53, and 33; 76.6% of patients with precancerous cervical lesions were infected with high‐risk HPVs, and the top 5 infectious subtypes were 16, 52, 58, 33, and 18 . Studies have shown that HPV subtypes have significant age and regional specificities, which differed in different levels of precancerous cervical lesions and cervical cancer . There exist standard cervical cancer screening guidelines in mainland China.…”

mentioning

confidence: 99%

The distribution and prevalence of human papillomavirus in women in mainland China

Song

et al. 2019

Cancer

133

View full text Add to dashboard Cite

We conducted a systematic review of the epidemiology of high-risk human papillomavirus (HPV) infections in mainland Chinese women to provide a general profile for the application and subsequent effectiveness evaluation of HPV vaccines. The PubMed, Web of Science, Medline (Ovid), China National Knowledge Infrastructure, and Wanfang databases were used for the literature search. The epidemiological studies published from January 2000 to June 2018 on high-risk HPVs in mainland Chinese women were investigated to systematically evaluate their epidemiological status. A total of 198 eligible studies were included. The results of metaanalysis showed that the overall infection rate of high-risk HPVs in mainland Chinese women was 19.0% (95% confidence interval [CI], 17.1%-20.9%), and the top 5 subtypes with the highest infection rates were 16, 52, 58, 53, and 18. The overall infection rates of cervical intraepithelial neoplasia I (CINI), CINII+, and cervical cancer patients were 59.6% (95% CI, 52.7%-66.4%), 84.8% (95% CI, 81.2%-88.5%), and 89.9% (95% CI, 86.6%-93.1%), respectively. The high-risk HPV infections and common subtypes in women of various ages in various regions were different, and the high-risk HPVs and subtypes in cervical cancer patients in various regions were also different. In conclusion, we systematically analyzed the HPV infections in women who live on the Chinese mainland. The epidemiology of high-risk HPVs in mainland Chinese women is basically consistent with that for the rest of the world. The HPV vaccines currently licensed in China could cover the major prevalent high-risk HPV subtypes in China, providing a basis for the development of cervical cancer screening strategy and the vaccine implementation in China.

show abstract

Human papillomavirus infections among women with cervical lesions and cervical cancer in Eastern China: genotype-specific prevalence and attribution

Cited by 47 publications

References 25 publications

Distribution and attribution of high-risk human papillomavirus genotypes in cervical precancerous lesions in China

Distribution and attribution of high-risk human papillomavirus genotypes in cervical precancerous lesions in China

The Prevalence of Human Papillomavirus Genotypes in Women with Abnormal Cervical Cytology

The distribution and prevalence of human papillomavirus in women in mainland China

Contact Info

Product

Resources

About